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Perevezentsev O.A.

Rostov State Medical University of the Ministry of Health of the Russian Federation;
GBUZ Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Mamedov I.S.

GBUZ Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Dimitriadi T.A.

Rostov State Medical University of the Ministry of Health of the Russian Federation

Relationship between genetic variants of coagulation system genes with venous thrombosis in women during pregnancy

Authors:

Perevezentsev O.A., Mamedov I.S., Dimitriadi T.A.

More about the authors

Journal: Laboratory Service. 2025;14(2): 19‑23

DOI: 10.17116/labs20251402119

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Table of contents

RELATIONSHIP BETWEEN GENETIC VARIANTS OF COAGULATION SYSTEM GENES WITH VENOUS THROMBOSIS IN WOMEN DURING PREGNANCY
RELATIONSHIP BETWEEN GENETIC VARIANTS OF COAGULATION SYSTEM GENES WITH VENOUS THROMBOSIS IN WOMEN DURING PREGNANCY

To cite this article:

Perevezentsev OA, Mamedov IS, Dimitriadi TA. Relationship between genetic variants of coagulation system genes with venous thrombosis in women during pregnancy. Laboratory Service. 2025;14(2):19‑23. (In Russ.)
https://doi.org/10.17116/labs20251402119

Подписка 2025 Лабораторная служба (Laboratory Service)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

INTRODUCTION

Venous thrombosis is etiopathogenetically associated with various pathologies characterized by an excessive tendency of the body to thrombosis in blood vessels. One of the types of disorders in the hemostasis system is venous thrombosis that occurs during pregnancy in women, which can lead to various gestational complications. Therefore, it is important to understand the etiopathogenesis of this pathological condition, including the contribution of hereditary factors.

OBJECTIVE

To analyze the association of 8 genetic variants of the hemostasis system genes and 4 folate metabolism genes with venous thrombosis in women that occurred during gestation.

MATERIALS AND METHODS

The study included 311 women aged 20 to 38 years, who were diagnosed with gestational venous thrombosis of various localizations during gestation, and 225 women in the control group. The study of the genotypes of the selected genetic variants was carried out by real-time PCR with melting curve analysis.

RESULTS

A positive association was found for 4 genetic variants: F2 c.20210G>A (OR=11.03, CI: 2.60—46.81, p<0.001); F5 c.1691G>A (OR=6.02, CI: 2.52—14.38, p<0.001); FGB c.–455 G>A (OR=5.65, CI: 3.05—10.45, p<0.001) and PAI-1 c.–675 5G>4G(OR=2.28, CI: 1.54—3.39, p<0.001).

CONCLUSION

Thus, we established an association of 4 genetic variants of plasma hemostatic factor genes with hereditary predisposition to venous thrombosis in women during pregnancy.

Keywords:

genetic variant
F2 c.20210G&gt;A
F5 c.1691G&gt;A
FGB c.–455 G&gt;A
PAI-1 c.–675 5G&gt;4G
venous thrombosis
pregnancy

Authors:

Perevezentsev O.A.

Rostov State Medical University of the Ministry of Health of the Russian Federation;
GBUZ Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Mamedov I.S.

GBUZ Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Dimitriadi T.A.

Rostov State Medical University of the Ministry of Health of the Russian Federation

Received:

14.02.2025

Accepted:

07.05.2025

Close metadata

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