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Kuz’menko G.N.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood

Panova I.A.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood

Klycheva M.M.

V.N. Gorodkov Scientific Research Institute of Maternity and Childhood

Ageev A.A.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood

Nazarov S.B.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood

Metabolic changes of platelets in pregnant women with hypertensive disorders according to platelet lysate indices

Authors:

Kuz’menko G.N., Panova I.A., Klycheva M.M., Ageev A.A., Nazarov S.B.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2024;24(4): 5‑12

DOI: 10.17116/rosakush2024240415

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Table of contents

METABOLIC CHANGES OF PLATELETS IN PREGNANT WOMEN WITH HYPERTENSIVE DISORDERS ACCORDING TO PLATELET LYSATE INDICES
METABOLIC CHANGES OF PLATELETS IN PREGNANT WOMEN WITH HYPERTENSIVE DISORDERS ACCORDING TO PLATELET LYSATE INDICES

To cite this article:

Kuz’menko GN, Panova IA, Klycheva MM, Ageev AA, Nazarov SB. Metabolic changes of platelets in pregnant women with hypertensive disorders according to platelet lysate indices. Russian Bulletin of Obstetrician-Gynecologist. 2024;24(4):5‑12. (In Russ.)
https://doi.org/10.17116/rosakush2024240415

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To reveal metabolic features of platelets in pregnant women with hypertensive disorders by platelet lysate indices.

MATERIAL AND METHODS

A total of 176 pregnant women with gestational age of 25-40 weeks were examined. The main group, including 128 pregnant women with hypertensive disorders, was divided into the 1st subgroup — 41 pregnant women with chronic arterial hypertension (CAH) and the 2nd subgroup — 87 patients with preeclampsia (PE), including 48 pregnant women with de novo PE (2a subgroup) and 39 patients with PE due to CAH (2b subgroup). The control group included 48 pregnant women without signs of hypertensive disorders. Hematologic parameters were studied with determination of platelet count and average platelet volume. The levels of lactate dehydrogenase, magnesium lactate, creatine kinase were evaluated in platelet lysates.

RESULTS

Pregnant women with PE had an increase in the average platelet volume, increased levels of lactate dehydrogenase and magnesium lactate in platelets circulating in the blood-borne bloodstream due to increased anaerobic glycolysis, increased levels of intracellular magnesium in platelet lysates in plasma-free medium, and increased creatine kinase activity in platelet-rich plasma lysates. Platelets of pregnant women with PE and PE with CAH alter their metabolic status in response to pathologic changes characteristic of hypertensive disorders.

CONCLUSION

Studies of metabolic features of platelets in pregnant women with hypertensive disorders according to platelet lysates indicate increased metabolic activity of platelets in women with PE and expand the understanding of the mechanisms of development of this complication of pregnancy. This will contribute to the development of new diagnostic methods, differential diagnosis of PE and may reveal new drug targets for the treatment of pregnant women with prothrombotic tendencies in PE.

Keywords:

pregnancy
hypertensive disorders
platelet lysates
platelet metabolic changes

Authors:

Kuz’menko G.N.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood

Panova I.A.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood

Klycheva M.M.

V.N. Gorodkov Scientific Research Institute of Maternity and Childhood

Ageev A.A.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood

Nazarov S.B.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood

Received:

14.07.2023

Accepted:

02.10.2023

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