The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kuz’menko G.N.

V.N. Gorodkov Scientific Research Institute of Maternity and Childhood

Panova I.A.

V.N. Gorodkov Scientific Research Institute of Maternity and Childhood

Klycheva M.M.

V.N. Gorodkov Scientific Research Institute of Maternity and Childhood

Ageev A.A.

V.N. Gorodkov Scientific Research Institute of Maternity and Childhood

Nazarov S.B.

V.N. Gorodkov Scientific Research Institute of Maternity and Childhood

Metabolic changes of platelets in pregnant women with hypertensive disorders according to platelet lysate indices

Authors:

Kuz’menko G.N., Panova I.A., Klycheva M.M., Ageev A.A., Nazarov S.B.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2024;24(4): 5‑12

DOI: 10.17116/rosakush2024240415

Read: 461 times

Buy for 300₽
Contact the author
Table of contents

METABOLIC CHANGES OF PLATELETS IN PREGNANT WOMEN WITH HYPERTENSIVE DISORDERS ACCORDING TO PLATELET LYSATE INDICES
METABOLIC CHANGES OF PLATELETS IN PREGNANT WOMEN WITH HYPERTENSIVE DISORDERS ACCORDING TO PLATELET LYSATE INDICES

To cite this article:

Kuz’menko GN, Panova IA, Klycheva MM, Ageev AA, Nazarov SB. Metabolic changes of platelets in pregnant women with hypertensive disorders according to platelet lysate indices. Russian Bulletin of Obstetrician-Gynecologist. 2024;24(4):5‑12. (In Russ.)
https://doi.org/10.17116/rosakush2024240415

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Mediasphera_Net
Close metadata
Recommended articles:
«Cytokine storm» as an immu­nopathologic reaction in pregnant women in the first trimester. Russian Bulletin of Obstetrician-Gynecologist. 2024;(5):19-24
Possible invo­lvement of the endo­cannabinoid system in the regu­lation of uterine contractile acti­vity in pregnant women and indu­ction of labor. Russian Bulletin of Obstetrician-Gynecologist. 2024;(5):25-33
Effe­ctiveness of socio-psychological programs in improving the performance of peri­natal center. Russian Bulletin of Obstetrician-Gynecologist. 2024;(5):77-82
Features of the course and tactics of pregnancy mana­gement in a patient with rela­pse of idiopathic apla­stic anemia. Russian Bulletin of Obstetrician-Gynecologist. 2024;(5):90-94
The effect of pregnancy on multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7-2):43-49
Expe­rience in the mana­gement of pregnant patients with highly active multiple scle­rosis in the Moscow region. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7-2):72-78
Mana­gement of a patient with mechanical jaundice and chro­nic pancreatitis during pregnancy. Endo­scopic Surgery. 2024;(4):61-64
Calcium-phosphorus meta­bolism and assi­sted reproductive technologies: inte­rsection points. Russian Journal of Human Reproduction. 2024;(4):19-28
Preferable drugs for relief of migraine atta­cks and tension type headache in pregnant women. Russian Journal of Pain. 2024;(3):12-18

OBJECTIVE

To reveal metabolic features of platelets in pregnant women with hypertensive disorders by platelet lysate indices.

MATERIAL AND METHODS

A total of 176 pregnant women with gestational age of 25-40 weeks were examined. The main group, including 128 pregnant women with hypertensive disorders, was divided into the 1st subgroup — 41 pregnant women with chronic arterial hypertension (CAH) and the 2nd subgroup — 87 patients with preeclampsia (PE), including 48 pregnant women with de novo PE (2a subgroup) and 39 patients with PE due to CAH (2b subgroup). The control group included 48 pregnant women without signs of hypertensive disorders. Hematologic parameters were studied with determination of platelet count and average platelet volume. The levels of lactate dehydrogenase, magnesium lactate, creatine kinase were evaluated in platelet lysates.

RESULTS

Pregnant women with PE had an increase in the average platelet volume, increased levels of lactate dehydrogenase and magnesium lactate in platelets circulating in the blood-borne bloodstream due to increased anaerobic glycolysis, increased levels of intracellular magnesium in platelet lysates in plasma-free medium, and increased creatine kinase activity in platelet-rich plasma lysates. Platelets of pregnant women with PE and PE with CAH alter their metabolic status in response to pathologic changes characteristic of hypertensive disorders.

CONCLUSION

Studies of metabolic features of platelets in pregnant women with hypertensive disorders according to platelet lysates indicate increased metabolic activity of platelets in women with PE and expand the understanding of the mechanisms of development of this complication of pregnancy. This will contribute to the development of new diagnostic methods, differential diagnosis of PE and may reveal new drug targets for the treatment of pregnant women with prothrombotic tendencies in PE.

Keywords:

pregnancy
hypertensive disorders
platelet lysates
platelet metabolic changes

Authors:

Kuz’menko G.N.

V.N. Gorodkov Scientific Research Institute of Maternity and Childhood

Panova I.A.

V.N. Gorodkov Scientific Research Institute of Maternity and Childhood

Klycheva M.M.

V.N. Gorodkov Scientific Research Institute of Maternity and Childhood

Ageev A.A.

V.N. Gorodkov Scientific Research Institute of Maternity and Childhood

Nazarov S.B.

V.N. Gorodkov Scientific Research Institute of Maternity and Childhood

Received:

14.07.2023

Accepted:

02.10.2023

List of references:

  1. Abramova MYu. Genetic markers of severe preeclampsia. Nauchnye rezul’taty biomeditsinskikh issledovanii. 2022;8:3:305-316. (In Russ.). https://doi.org/10.18413/2658-6533-2022-8-3-0-4
  2. Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: pathophysiology, challenges, and perspectives. Circ Res. 2019;124:7:1094-1112. https://doi.org/10.1161/CIRCRESAHA.118.313276
  3. Ives CW, Sinkey R, Rajapreyar I, Tita ATN, Oparil S. Preeclampsia-pathophysiology and clinical presentations: JACC State-of-the-Art review. J Am Coll Cardiol. 2020;76:14:1690-1702. https://doi.org/10.1016/j.jacc.2020.08.014
  4. Miller D, Motomura K, Galaz J, Gershater M, Lee ED, Romero R, Gomez-Lopez N. Cellular immune responses in the pathophysiology of preeclampsia. J Leukoc Biol. 2022;111:1:237-260.  https://doi.org/10.1002/JLB.5RU1120-787RR
  5. Mereweather LJ, Constantinescu-Bercu A, Crawley JTB, Salles-Crawley II. Platelet-neutrophil crosstalk in thrombosis. Int J Mol Sci. 2023;24:2:1266. https://doi.org/10.3390/ijms24021266
  6. Xu XR, Zhang D, Oswald BE, Carrim N, Wang X, Hou Y, Zhang Q, Lavalle C, McKeown T, Marshall AH, Ni H. Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond. Crit Rev Clin Lab Sci. 2016;53:6:409-430.  https://doi.org/10.1080/10408363.2016.1200008
  7. Battinelli EM. The role of platelets in angiogenesis. Editor(s): Alan D. Michelson. Platelets (Fourth Edition), Academic Press. 2019;433-441.  https://doi.org/10.1016/B978-0-12-813456-6.00024-2
  8. Grinstein IYu, Savchenko AA, Savchenko EA, Kosinova AA, Grinstein YuI. Metabolic platelet status in patients with stable angina. Rossiiskii kardiologicheskii zhurnal. 2013;6:23-27. (In Russ.). https://doi.org/10.15829/1560-4071-2013-6-23-27
  9. Sake CL, Metcalf AJ, Meagher M, Di PJ, Neeves KB, Boyle NR. Isotopically nonstationary 13C metabolic flux analysis in resting and activated human platelets. Metab Eng. 2022;69:313-322.  https://doi.org/10.1016/j.ymben.2021.12.007
  10. Malinow AM, Schuh RA, Alyamani O, Kim J, Bharadwaj S, Crimmins SD, Galey JL, Fiskum G, Polster BM. Platelets in preeclamptic pregnancies fail to exhibit the decrease in mitochondrial oxygen consumption rate seen in normal pregnancies. Biosci Rep. 2018;38:3:BSR20180286. https://doi.org/10.1042/BSR20180286
  11. Sadov RI, Panova IA, Nazarov SB, Kuz’menko GN, Popova IG, Kharlamova NV. The features of secretory activity of platelets and fibrinolysis in women with various types of hypertensive disorders in the third trimester of pregnancy. Tromboz, gemostaz i reologiya. 2020;4:78-86. (In Russ.). https://doi.org/10.25555/THR.2020.4.0949
  12. Bakunovich AV, Bichan OD, Lobanok LM. Calcium homeostasis in platelets during pregnancy complicated by preeclampsia. Molecular, membrane and cellular bases of biosystems functioning: proceedings of the International scientific conference and the Twelfth congress of the Belarusian public association of photobiologists and biophysicists. Redkol.: I.D. Volotovskii [i dr.]. V 2 ch. CH. 1. Minsk: Izd. centr BGU; 2016;311-313. (In Russ.).
  13. Patent №2739515 C1 Rossiiskaya Federatsiya, MPK A61K 35/19, G01N 33/49, B01D 21/26. Sposob prigotovleniya lizata trombocitov s vysokim soderzhaniem faktorov rosta: №2020115128: zayavl. 29.04.2020: opubl. 25.12.2020/N.V. Borovkova, M.S. Makarov, M.V. Storozheva, I.N. Ponomarev; zayavitel’ Gosudarstvennoe byudzhetnoe uchrezhdenie zdravoohraneniya goroda Moskvy «Nauchno-issledovatel’skii institut skoroj pomoshchi im. N.V. Sklifosovskogo Departamenta zdravookhraneniya goroda Moskvy» (GBUZ «NII SP im. N.V. Sklifosovskogo DZM»). (In Russ.).
  14. Saleem FR, Chandru S, Biswas M. Evaluation of total LDH and its isoenzymes as markers in preeclampsia. J Med Biochem. 2020;39:3:392-398.  https://doi.org/10.2478/jomb-2019-0045
  15. Khidri FF, Shaikh F, Khowaja IU, Riaz H. Role of lactate dehydrogenase in the prediction of severity in pre-eclampsia. Curr Hypertens Rev. 2020;16:3:223-228.  https://doi.org/10.2174/1573402116666200720001032
  16. Burwick RM, Rincon M, Beeraka SS, Gupta M, Feinberg BB. Evaluation of hemolysis as a severe feature of preeclampsia. Hypertension. 2018;72:2:460-465.  https://doi.org/10.1161/HYPERTENSIONAHA.118.11211
  17. Pergialiotis V, Panagiotopoulos M, Bellos I, Theodora M, Stavros S, Ntomali E, Papapanagiotou A, Daskalakis G. Serum LDH values in hypertensive disorders of pregnancy and their association with maternal and neonatal morbidity: A meta-analysis. Int J Clin Pract. 2021;75:12:e14986. https://doi.org/10.1111/ijcp.14986
  18. https://science-education.ru/ru/article/view?id=29530  https://science-education.ru/ru/article/view?id=29530
  19. https://cyberleninka.ru/article/n/sovremennye-predstavleniya-o-preeklampsii-patogenez-diagnostika-prognozirovanie https://cyberleninka.ru/article/n/sovremennye-predstavleniya-o-preeklampsii-patogenez-diagnostika-prognozirovanie
  20. Aibibula M, Naseem KM, Sturmey RG. Glucose metabolism and metabolic flexibility in blood platelets. J Thromb Haemost. 2018;16:11:2300-2314. https://doi.org/10.1111/jth.14274
  21. George MJ, Bynum J, Nair P, Cap AP, Wade CE, Cox CS Jr, Gill BS. Platelet biomechanics, platelet bioenergetics, and applications to clinical practice and translational research. Platelets. 2018;29:5:431-439.  https://doi.org/10.1080/09537104.2018.1453062
  22. Haliulin AV, Gusyakova OA, Kozlov AV, Gabril’chak AI. Metabolism processes and mechanisms of regulation of platelet activity (review of literature). Klinicheskaya laboratornaya diagnostika. 2019;64:3:164-169. (In Russ.). https://doi.org/10.18821/0869-2084-2019-64-3-164-169
  23. Basu D, Basu S, Radhakrishnan VS, Bhattacharya S, Chakraborty S, Sinha S, Chandy M. Comparison of quality and efficacy of apheresis platelets stored in platelet additive solution vis a vis plasma. Indian J Hematol Blood Transfus. 2021;37:4:648-657.  https://doi.org/10.1007/s12288-021-01408-x
  24. D’Alessandro A, Stefanoni D, D’Alessandro A, Stefanoni D, Slichter SJ, Fu X, Zimring JC. The impact of donor sex and age on stored platelet metabolism and post-transfusion recovery. Blood Transfus. 2021;19:3:216-223.  https://doi.org/10.2450/2020.0145-20
  25. Brewster LM, Karamat FA, van Montfrans GA. Creatine kinase and blood pressure: a systematic review. Med Sci (Basel). 2019;7:4:58.  https://doi.org/10.3390/medsci7040058
  26. Shilov AM, Osiya AO. Magnesium deficiency and cardiovascular diseases: pathophysiology and treatment in primary health care. RMZh. 2014;2:156. (In Russ.).
  27. Dominguez L, Veronese N, Barbagallo M. Magnesium and hypertension in old age. Nutrients. 2020;13:1:139.  https://doi.org/10.3390/nu13010139
  28. Bakunovich AV, Bulanova KYa. Structural and functional rearrangements of platelets in preeclampsia of pregnant women. Zhurn. Belorus. gos. un-ta. Ekologiya. 2018;4:76-83. (In Russ.).
  29. Elmugabil A, Hamdan HZ, Elsheikh AE, Rayis DA, Adam I, Gasim GI. Serum calcium, magnesium, zinc and copper levels in sudanese women with preeclampsia. PLoS One. 2016;11:12:e0167495. https://doi.org/10.1371/journal.pone.0167495
  30. Chawla N, Shah H, Huynh K, Braun A; Wollocko H, Shah NC. The role of platelet-activating factor and magnesium in obstetrics and gynecology: is there crosstalk between pre-eclampsia, clinical hypertension and HELLP syndrome? Biomedicines. 2023;11:5:1343. https://doi.org/10.3390/biomedicines11051343
  31. Jafrin W, Mia AR, Chakraborty PK, Hoque MR, Paul UK, Shaha KR, Akhter S, Roy AS. An evaluation of serum magnesium status in pre-eclampsia compared to the normal pregnancy. Mymensingh Med J. 2014;23:4:649-653. 
  32. Dalton LM, Ní Fhloinn DM, Gaydadzhieva GT, Mazurkiewicz OM, Leeson H, Wright CP. Magnesium in pregnancy. Nutr Rev. 2016;74:9:549-557.  https://doi.org/10.1093/nutrit/nuw018
  33. Udenze IC, Arikawe AP, Azinge EC, Okusanya BO, Ebuehi OA. Calcium and magnesium metabolism in pre-eclampsia. West Afr J Med. 2014;33:3:178-182. 
  34. Van Laecke S. Hypomagnesemia and hypermagnesemia. Acta Clin Belg. 2019;74:1:41-47.  https://doi.org/10.1080/17843286.2018.1516173
  35. Winarno GNA, Pribadi A, Maruli HJ, Achmad ED, Anwar R, Mose JC, Nisa AS, Trianasari N. Ratio of serum calcium to magnesium levels on pregnancy with and without preeclampsia. Med Sci Monit. 2021;27:e932032. https://doi.org/10.12659/MSM.932032
  36. Aurich K, Wesche J, Ulbricht M, Otto O, Greinacher A, Palankar R. Divalent magnesium restores cytoskeletal storage lesions in cold-stored platelet concentrates. Sci Rep. 2022;12:1:6229. https://doi.org/10.1038/s41598-022-10231-x
  37. Mannuß S. Influence of different methods and anticoagulants on platelet parameter measurement. J Laboratory Med. 2020;44:5:255-272.  https://doi.org/10.1515/labmed-2020-0037
  38. Daw CC, Ramachandran K, Enslow BT, Maity S, Bursic B, Novello MJ, Rubannelsonkumar CS, Mashal AH, Ravichandran J, Bakewell TM, Wang W, Li K, Madaris TR, Shannon CE, Norton L, Kandala S, Caplan J, Srikantan S, Stathopulos PB, Reeves WB, Madesh M. Lactate elicits ER-Mitochondrial Mg2+ dynamics to integrate cellular metabolism. Cell. 2020;183:2:474-489.e17.  https://doi.org/10.1016/j.cell.2020.08.049
  39. Panova I.A., Kuz’menko G.N., Sadov R.I., Sytova L.A., Nazarov S.B. Clinical value of variations of morphometric values of thrombocytes in female patients with hypertension disorders in the third trimester of pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2020;20:1:16-21. (In Russ.). https://doi.org/10.17116/rosakush20202001116

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.