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Orlova E.A.

Penza Institute for Further Training of Physicians — Branch of the Russian Medical Academy for Continuous Professional Education

Kandrashkina Yu.A.

Penza State University

Levashova O.A.

Penza Institute for Further Training of Physicians — Branch of the Russian Medical Academy for Continuous Professional Education

Kostina E.M.

Penza Institute for Further Training of Physicians — Branch of the Russian Medical Academy for Continuous Professional Education

Dynamics of Substance P and Filaggrin Levels on Combined Treatment of Atopic Dermatitis with Emollient and Topical Antipruritic Drug in Pregnant Women

Authors:

Orlova E.A., Kandrashkina Yu.A., Levashova O.A., Kostina E.M.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2024;23(6): 662‑666

DOI: 10.17116/klinderma202423061662

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To cite this article:

Orlova EA, Kandrashkina YuA, Levashova OA, Kostina EM. Dynamics of Substance P and Filaggrin Levels on Combined Treatment of Atopic Dermatitis with Emollient and Topical Antipruritic Drug in Pregnant Women. Russian Journal of Clinical Dermatology and Venereology. 2024;23(6):662‑666. (In Russ.)
https://doi.org/10.17116/klinderma202423061662

 
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BACKGROUND

The relevance of atopic dermatitis (AD) problem is due to the rather wide prevalence of disease, as well as the tendency to worsening the course of skin inflammation process. The AD treatment in pregnant women remains a challenge, as most drugs are forbidden for use in this group of patients. We have proposed a complex of moisturizing and antipruritic drugs to optimize the external therapy in pregnant women.

OBJECTIVE

To assess the impact of suggested combination on the levels of skin protective protein, namely filaggrin (FLG), and neuropeptide, namely substance P (SP).

MATERIAL AND METHODS

The number of pregnant women with AD exacerbation equal 76 was examined. The level of SP and FLG in blood serum was detected by enzyme-linked immunoelectrodiffusion essay at the first visit and 4 weeks after beginning of complex treatment use with moisturizing and antipruritic drugs.

RESULTS

Lower FLG concentrations in blood serum have been revealed in pregnant women with AD exacerbation on the proposed treatment compared to the indicator before therapy (p=0.001). The SP level hasn’t changed in blood serum after treatment.

CONCLUSION

The complex of emollient and topical antipruritic drug decreases the FLG concentration in blood serum, although there are no significant changes in SP level.

Keywords:

atopic dermatitis
pregnancy
emollient
topical antipruritic drug
substance P
filaggrin

Authors:

Orlova E.A.

Penza Institute for Further Training of Physicians — Branch of the Russian Medical Academy for Continuous Professional Education

Kandrashkina Yu.A.

Penza State University

Levashova O.A.

Penza Institute for Further Training of Physicians — Branch of the Russian Medical Academy for Continuous Professional Education

Kostina E.M.

Penza Institute for Further Training of Physicians — Branch of the Russian Medical Academy for Continuous Professional Education

Received:

19.05.2024

Accepted:

22.09.2024

List of references:

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