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Zagidulina A.R.
Bashkir State Medical University
Zagretdinova D.R.
Bashkir State Medical University
Mukhamadieva A.M.
Bashkir State Medical University
Esenalieva B.D.
Bashkir State Medical University
Garipova E.R.
Bashkir State Medical University
Galiev T.M.
Bashkir State Medical University
Prospects of human microbiome study for better understanding of ovarian cancer pathogenesis
Journal: Russian Bulletin of Obstetrician-Gynecologist. 2023;23(1): 39‑46
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To cite this article:
Khamad’yanova AU, Zagidulina AR, Zagretdinova DR, et al. . Prospects of human microbiome study for better understanding of ovarian cancer pathogenesis. Russian Bulletin of Obstetrician-Gynecologist.
2023;23(1):39‑46. (In Russ.)
https://doi.org/10.17116/rosakush20232301139
The authors of the present report describe ovarian cancer (OC) as one of the most severe diseases in gynaecological oncology with a high incidence and lethality rate. Every year more than 200 000 new cases and 150 000 deaths from OC are discovered in the world. Human microbiome is a complex ecosystem inhabited by various microorganisms living mainly in epidermal tissues and mucous membranes of the body. The aim of the study is to review the foreign literature on the relationship between the microbiome and OC, and to assess the potential role of the microbiome in the treatment of OC. The microbiome plays an important role in maintaining the normal physiological state of the human body, and pathological changes in it can most often be associated with various diseases, including OC. Thanks to the development of technologies such as high-throughput DNA sequencing and 16S rRNA (nucleotide sequence determination in DNA and RNA), more and more new aspects of the human microbiome are being revealed. Probiotic bacteria have demonstrated their potential to prevent and treat cancer. Despite an increasing number of studies indicating a link between the microbiome and RNA, the mechanisms underlying this link are not fully elucidated. In particular, the specific microorganisms involved in the pathogenesis of OC have not been identified. Further research aimed at finding microbiome biomarkers of OC is relevant. The microbiome also shows good potential as an adjunct to the treatment of advanced, relapsing and chimioresistant OC. Therapies that activate innate immunity have shown promising results by effectively suppressing cancer cells. Given the important immune function of the microbiome, the focus of therapy has shifted from microbiome regulation to the development of microbial monocultures that can regulate the immune system. Further research in this direction should focus on identifying specific metabolites and immunomodulatory molecules produced by microorganisms as well as specific components of the microbiome associated with different types of OC.
Keywords:
Authors:
Zagidulina A.R.
Bashkir State Medical University
Zagretdinova D.R.
Bashkir State Medical University
Mukhamadieva A.M.
Bashkir State Medical University
Esenalieva B.D.
Bashkir State Medical University
Garipova E.R.
Bashkir State Medical University
Galiev T.M.
Bashkir State Medical University
Received:
21.04.2022
Accepted:
26.05.2022
List of references:
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