The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Rodionova V.A.

Samara Regional Clinical Oncology Dispensary

Lebedev P.A.

Samara State Medical University

Paranina E.V.

Samara State Medical University

Kuzmin V.P.

Polyakov Samara Regional Clinical Cardiology Dispensary

Left ventricular myocardial performance index (Tei index) as an early marker of cardiotoxicity in antitumor therapy

Authors:

Rodionova V.A., Lebedev P.A., Paranina E.V., Kuzmin V.P.

More about the authors

Journal: Russian Cardiology Bulletin. 2024;19(4‑2): 137‑143

DOI: 10.17116/Cardiobulletin202419042137

Read: 1614 times

Download PDF (RU)
Contact the author
Table of contents

LEFT VENTRICULAR MYOCARDIAL PERFORMANCE INDEX (TEI INDEX) AS AN EARLY MARKER OF CARDIOTOXICITY IN ANTITUMOR THERAPY
LEFT VENTRICULAR MYOCARDIAL PERFORMANCE INDEX (TEI INDEX) AS AN EARLY MARKER OF CARDIOTOXICITY IN ANTITUMOR THERAPY

To cite this article:

Rodionova VA, Lebedev PA, Paranina EV, Kuzmin VP. Left ventricular myocardial performance index (Tei index) as an early marker of cardiotoxicity in antitumor therapy. Russian Cardiology Bulletin. 2024;19(4‑2):137‑143. (In Russ.)
https://doi.org/10.17116/Cardiobulletin202419042137

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Clinical mani­festation of apical hype­rtrophic cardiomyopathy by syncope in the elde­rly. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(2):237-243
The effect of acetylamide synthetic peptide HLDF-6 on cell differentiation in breast cancer. Russian Journal of Archive of Pathology. 2025;(2):5-10
Treatment outcomes of stage IIA–IIB breast cancer patients of hormone-positive HER2-negative subtype after neoadjuvant poly­chemotherapy depe­nding on Ki-67 levels. P.A. Herzen Journal of Onco­logy. 2025;(2):13-18
The impact of abdo­minal obesity correction in mature women on the stru­ctural and functional para­meters of the myocardium and lipid meta­bolism para­meters. Russian Journal of Preventive Medi­cine. 2025;(4):75-81
Correlation of motor symptoms and cardiovascular dysfunction in Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):59-67
Repeated breast reco­nstruction after previous complications. Piro­gov Russian Journal of Surgery. 2025;(6):51-57
Guidelines for asse­ssing the quality of mammographic images. Russian Journal of Preventive Medi­cine. 2025;(6):21-32
Hema­tological indi­cators of the systemic inflammatory response in the prognosis of lumi­nal HER2-negative breast cancer patients unde­rgoing surgery followed by adju­vant therapy. P.A. Herzen Journal of Onco­logy. 2025;(3):31-38
Hemo­stasis diso­rders during neoadjuvant therapy in patients with breast cancer. P.A. Herzen Journal of Onco­logy. 2025;(3):39-44
Use of HIFU therapy in combination with mono­chemotherapy in a patient with loca­lly adva­nced adenogenic pancreatic cancer and impaired functional status. P.A. Herzen Journal of Onco­logy. 2025;(3):83-88
Abstract:

Breast cancer is the most common cancer in women. Anthracycline drugs are the most common for chemotherapy in these patients. This therapy is associated with cardiotoxicity and primarily myocardial dysfunction. Left ventricular ejection fraction as a classic parameter of contractility has been criticized as a cardiotoxicity marker dependent on operator and image quality. Clinical practice requires simple and significant methods for diagnosis of cardiotoxicity using available integral parameters. In clinical study, the authors demonstrated high sensitivity of the left ventricular myocardial performance index (Tei index) as a marker of cardiotoxicity in comparison with LVEF, increase of high-sensitivity troponin (cTrI) and terminal natriuretic peptide precursor (NTproBNP), as well as heart rate variability (HRV) parameters.

Keywords:

breast cancer
chemotherapy
myocardial performance index
Tei index
cardiotoxicity
echocardiography
heart rate variability
left ventricular ejection fraction

Authors:

Rodionova V.A.

Samara Regional Clinical Oncology Dispensary

Lebedev P.A.

Samara State Medical University

Paranina E.V.

Samara State Medical University

Kuzmin V.P.

Polyakov Samara Regional Clinical Cardiology Dispensary

Received:

29.01.2024

Accepted:

26.03.2024

Close metadata

References:

  1. Varghese SS, Eekhoudt CR, Jassal DS. Mechanisms of anthracycline-mediated cardiotoxicity and preventative strategies in women with breast cancer. Mol Cell Biochem. 2021 Aug;476(8):3099-3109. https://doi.org/10.1007/s11010-021-04152-y
  2. Padegimas A, Clasen S, Ky B. Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity. Trends Cardiovasc Med. 2020 Jan;30(1):22-28.  https://doi.org/10.1016/j.tcm.2019.01.006
  3. Giordano SH, Lin YL, Kuo YF, Hortobagyi GN, Goodwin JS. Decline in the use of anthracyclines for breast cancer. J Clin Oncol. 2012 Jun 20;30(18):2232-9.  https://doi.org/10.1200/JCO.2011.40.1273
  4. Narayan HK, Finkelman B, French B, Plappert T, Hyman D, Smith AM, et al. Detailed Echocardiographic Phenotyping in Breast Cancer Patients: Associations With Ejection Fraction Decline, Recovery, and Heart Failure Symptoms Over 3 Years of Follow-Up. Circulation. 2017. April 11;135(15):1397-412. 
  5. Thavendiranathan P, Grant AD, Negishi T, et al. Reproducibility of echocardiographic techniques for sequential assessment of left ventricular ejection fraction and volumes: application to patients undergoing cancer chemotherapy. J Am Coll Cardiol. 2013;61:77-84.  https://doi.org/10.1016/j.jacc.2012.09.035
  6. Chung R, Ghosh AK, Banerjee A. Cardiotoxicity: precision medicine with imprecise definitions. Open Heart. 2018 Jul 25;5(2):e000774. https://doi.org/10.1136/openhrt-2018-000774
  7. Di Lisi D, Bonura F, Macaione F, Peritore A, Meschisi M, Cuttitta F, Novo G, D’Alessandro N, Novo S. Chemotherapy-induced cardiotoxicity: role of the tissue Doppler in the early diagnosis of left ventricular dysfunction. Anticancer Drugs. 2011 Jun;22(5):468-72.  https://doi.org/10.1097/CAD.0b013e3283443704
  8. Patel CD, Balakrishnan VB, Kumar L, Naswa N, Malhotra A. Does left ventricular diastolic function deteriorate earlier than left ventricular systolic function in anthracycline cardiotoxicity? Hell J Nucl Med. 2010 Sep-Dec;13(3):233-7. 
  9. Tei C. New non-invasive index for combined systolic and diastolic ventricular function. J Cardiol. 1995 Aug;26(2):135-6. 
  10. Ayhan SS, Özdemir K, Kayrak M, Bacaksiz A, Vatankulu MA, Eren Ö, Koc F, Duman C, Gülec H, Demir K, Ari H, Sönmez O, Gök H. The evaluation of doxorubicin-induced cardiotoxicity: comparison of Doppler and tissue Doppler-derived myocardial performance index. Cardiol J. 2012;19(4):363-8.  https://doi.org/10.5603/cj.2012.0066
  11. Lebedev PA, Ivanova OF, Paranina EV, Vvedenskaya IP. Pod obshchej red. PA Lebedeva; FGBOU VO SamGMU MZ RF.-Samara: OOO .OFORT., 2019. — 67s (In Russ.)
  12. Vasyuk Yu.A., Gendlin G.E., Emelina E.I. et al. Consensus statement of Russian experts on the prevention, diagnosis and treatment of cardiotoxicity of anticancer therapy. Russian Journal of Cardiology. 2021;26(9):4703. (In Russ.) https://doi.org/10.15829/1560-4071-2021-4703
  13. Kulbacka-Ortiz K, Triest FJJ, Franssen FME. et al. Restricted spirometry and cardiometabolic comorbidities: results from the international population based BOLD study. Respir Res. 2022 Feb 17;23(1):34.  https://doi.org/10.1186/s12931-022-01939-5
  14. Cardinale D, Colombo A, Bacchiani G. et al. Improvement With Heart Failure Therapy. Circulation. 2015. June 2;131(22):1981-8. 
  15. Zamorano JL, Gottfridsson C, Asteggiano R. et al. The cancer patient and cardiology. Eur J Heart Fail. 2020 Dec;22(12):2290-2309. https://doi.org/10.1002/ejhf.1985
  16. Cardinale D, Ciceri F, Latini R. et al. Anthracycline‐induced cardiotoxicity: a multicenter randomised trial comparing two strategies for guiding prevention with enalapril: the International CardioOncology Society‐one trial. Eur J Cancer. 2018;94:126-137. 
  17. Alexandre J, Cautela J, Ederhy S. Cardiovascular Toxicity Related to Cancer Treatment: A Pragmatic Approach to the American and European Cardio-Oncology Guidelines. J Am Heart Assoc. 2020 Sep 15;9(18): e018403. https://doi.org/10.1161/JAHA.120.018403
  18. Ayhan SS, Özdemir K, Kayrak M. et al. The evaluation of doxorubicin-induced cardiotoxicity: comparison of Doppler and tissue Doppler-derived myocardial performance index. Cardiol J. 2012;19(4):363-8.  https://doi.org/10.5603/cj.2012.0066
  19. Goroshi M, Chand D. Myocardial Performance Index (Tei Index): A simple tool to identify cardiac dysfunction in patients with diabetes mellitus. Indian Heart J. 2016 Jan-Feb;68(1):83-7.  https://doi.org/10.1016/j.ihj.2015.06.022
  20. Lakomkin VL, Abramov AA, Gramovich VV. et al. Relationship between diastolic and systolic myocardial dysfunction at doxorubicin cardiomyopathy. Russian Cardiology Bulletin. 2018;13(2):48-52. (In Russ.) https://doi.org/10.17116/Cardiobulletin201813248
  21. Puzzovivo A, Fioretti AM, Minoia C, Villoni R. et al. Echocardiography Monitoring during Anthracycline Administration in Hodgkin and Non-Hodgkin’s Lymphoma: The Tei Index Evaluation. J Pers Med. 2022 Feb 16;12(2):290.  https://doi.org/10.3390/jpm12020290
  22. Bennett S, Cubukcu A, Wong CW. et al. The role of the Tei index in assessing for cardiotoxicity from anthracycline chemotherapy: a systematic review. Echo Res Pract. 2021 May 7;8(1):R1-R11.  https://doi.org/10.1530/ERP-20-0013
  23. Zhang CJ, Pei XL, Song FY. et al. Early anthracycline-induced cardiotoxicity monitored by echocardiographic Doppler parameters combined with serum hs-cTnT. Echocardiography. 2017 Nov;34(11):1593-1600. https://doi.org/10.1111/echo.13704
  24. Mizia-Stec K, Gościńska A, Mizia M. et al. Anthracycline chemotherapy impairs the structure and diastolic function of the left ventricle and induces negative arterial remodeling. Kardiologia Polska. 2013;71:681-690.  https://doi.org/10.5603/KP.2013.0154
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.