Gut microbiota: role in human health and potential for personalized medicine

Prokhorova N.D.; Gospodarik A.V.; Bespyatykh Yu.A.

doi:https://doi.org/10.17116/dokgastro20241304181

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OBJECTIVE

To analyze current data on the role of gut microbiota in maintaining human health and explore its potential applications in personalized medicine.

KEY POINTS

Current research highlights the dynamic and variable nature of the gut microbiota, with differences observed across age, geographic regions, and ethnicities. The balance between major bacterial phyla, such as Bacillota and Bacteroidetes, is particularly important in determining susceptibility to metabolic disorders. Advances in sequencing technologies have significantly improved the understanding of microbiota composition and function. Fecal microbiota transplantation (FMT) shows promise for treating several diseases, though challenges in donor selection remain.

CONCLUSION

The gut microbiota plays a critical role in maintaining human health and homeostasis. Personalized medicine, informed by microbiota composition, may become a cornerstone of future medical treatments. Continued research is essential to establish normal ranges of microbial diversity and develop therapeutic interventions to preserve or restore it.

Keywords:

gut microbiota

microbiome

human health

fecal microbiota transplantation

personalized medicine

Authors:

Prokhorova N.D.

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency

ORCID: 0000-0001-6485-1056

Gospodarik A.V.

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency

ORCID: 0009-0003-7870-1106

Bespyatykh Yu.A.

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency

ORCID: 0000-0002-4408-503X

Received:

10.10.2024

Accepted:

18.10.2024

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References:

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