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Prokhorova N.D.

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency

Gospodarik A.V.

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency

Bespyatykh Yu.A.

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency

Gut microbiota: role in human health and potential for personalized medicine

Authors:

Prokhorova N.D., Gospodarik A.V., Bespyatykh Yu.A.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2024;13(4): 81‑88

DOI: 10.17116/dokgastro20241304181

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GUT MICROBIOTA: ROLE IN HUMAN HEALTH AND POTENTIAL FOR PERSONALIZED MEDICINE
GUT MICROBIOTA: ROLE IN HUMAN HEALTH AND POTENTIAL FOR PERSONALIZED MEDICINE

To cite this article:

Prokhorova ND, Gospodarik AV, Bespyatykh YuA. Gut microbiota: role in human health and potential for personalized medicine. Russian Journal of Evidence-Based Gastroenterology. 2024;13(4):81‑88. (In Russ.)
https://doi.org/10.17116/dokgastro20241304181

Подписка 2025-2 (Russian Journal of Evidence-Based Gastroenterology)
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The relationship between gut microbiota and human health is increasingly recognized as pivotal in medical research and clinical practice. The gut microbiota performs essential physiological functions, from nutrient metabolism to immune regulation, underscoring its importance for lifelong health. Disruptions in microbiota composition have been linked to various pathological conditions, including metabolic syndrome, inflammatory bowel disease, and neurodegenerative disorders.

OBJECTIVE

To analyze current data on the role of gut microbiota in maintaining human health and explore its potential applications in personalized medicine.

KEY POINTS

Current research highlights the dynamic and variable nature of the gut microbiota, with differences observed across age, geographic regions, and ethnicities. The balance between major bacterial phyla, such as Bacillota and Bacteroidetes, is particularly important in determining susceptibility to metabolic disorders. Advances in sequencing technologies have significantly improved the understanding of microbiota composition and function. Fecal microbiota transplantation (FMT) shows promise for treating several diseases, though challenges in donor selection remain.

CONCLUSION

The gut microbiota plays a critical role in maintaining human health and homeostasis. Personalized medicine, informed by microbiota composition, may become a cornerstone of future medical treatments. Continued research is essential to establish normal ranges of microbial diversity and develop therapeutic interventions to preserve or restore it.

Keywords:

gut microbiota
microbiome
human health
fecal microbiota transplantation
personalized medicine

Authors:

Prokhorova N.D.

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency

Gospodarik A.V.

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency

Bespyatykh Yu.A.

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency

Received:

10.10.2024

Accepted:

18.10.2024

List of references:

  1. Gebrayel P, Nicco C, Al Khodor S, Bilinski J, Caselli E, Comelli EM, Egert M, Giaroni C, Karpinski TM, Loniewski I, Mulak A, Reygner J, Samczuk P, Serino M, Sikora M, Terranegra A, Ufnal M, Villeger R, Pichon C, Konturek P, Edeas M. Microbiota medicine: towards clinical revolution. Journal of Translational Medicine. 2022;20(1):111.  https://doi.org/10.1186/s12967-022-03296-9
  2. Yue YY, Fan XY, Zhang Q, Lu YP, Wu S, Wang S, Yu M, Cui CW, Sun ZR. Bibliometric analysis of subject trends and knowledge structures of gut microbiota. World Journal of Clinical Cases. 2020; 8(13):2817-2832. https://doi.org/10.12998/wjcc.v8.i13.2817
  3. Mikrobiota. Nikonov EL, Popova EN, eds. M.: Media Sphera; 2019. (In Russ.).
  4. Kaibysheva VO, Zharova ME, Filimendikova KYu, Nikonov EL. Human Microbiome: age-related changes and functions. Russian Journal of Evidence-Based Gastroenterology. 2020;9(2):42-55. (In Russ.). https://doi.org/10.17116/dokgastro2020902142
  5. Korem T, Zeevi D, Suez J, Weinberger A, Avnit-Sagi T, Pompan-Lotan M, Matot E, Jona G, Harmelin A, Cohen N, Sirota-Madi A, Thaiss CA, Pevsner-Fischer M, Sorek R, Xavier R, Elinav E, Segal E. Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples. Science. 2015;349(6252):1101-1106. https://doi.org/10.1126/science.aac4812
  6. Kaibysheva VO, Zharova ME, Filimendikova KYu, Nikonov EL. Diseases Associated with Disturbed Intestinal Microbiota. Doctor.Ru. 2021;20(4):40-45. (In Russ.). https://doi.org/10.31550/1727-2378-2021-20-4-40-45
  7. Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D. Role of the normal gut microbiota. World Journal of Gastroenterology. 2015;21(29):8787-8803. https://doi.org/10.3748/wjg.v21.i29.8787
  8. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027-1031. https://doi.org/10.1038/nature05414
  9. Thaiss CA, Itav S, Rothschild D, Meijer MT, Levy M, Moresi C, Dohnalová L, Braverman S, Rozin S, Malitsky S, Dori-Bachash M, Kuperman Y, Biton I, Gertler A, Harmelin A, Shapiro H, Halpern Z, Aharoni A, Segal E, Elinav E. Persistent microbiome alterations modulate the rate of post-dieting weight regain. Nature. 2016;540(7634):544-551.  https://doi.org/10.1038/nature20796
  10. Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nature Reviews. Microbiology. 2021;19(1):55-71.  https://doi.org/10.1038/s41579-020-0433-9
  11. Lloyd-Price J, Abu-Ali G, Huttenhower C. The healthy human microbiome. Genome Medicine. 2016;8(1):51.  https://doi.org/10.1186/s13073-016-0307-y
  12. Ding RX, Goh WR, Wu RN, Yue XQ, Luo X, Khine WWT, Wu JR, Lee YK. Revisit gut microbiota and its impact on human health and disease. Journal of Food and Drug Analysis. 2019;27(3):623-631.  https://doi.org/10.1016/j.jfda.2018.12.012
  13. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The human microbiome project. Nature. 2007;449 (7164):804-810.  https://doi.org/10.1038/nature06244
  14. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486 (7402):207-214.  https://doi.org/10.1038/nature11234
  15. Shafquat A, Joice R, Simmons SL, Huttenhower C. Functional and phylogenetic assembly of microbial communities in the human microbiome. Trends in Microbiology. 2014;22(5):261-266.  https://doi.org/10.1016/j.tim.2014.01.011
  16. Bodelier PL. Toward understanding, managing, and protecting microbial ecosystems. Frontiers in Microbiology. 2011;2:80.  https://doi.org/10.3389/fmicb.2011.00080
  17. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489(7415):220-230.  https://doi.org/10.1038/nature11550
  18. Brown JP. Role of gut bacterial flora in nutrition and health: a review of recent advances in bacteriological techniques, metabolism, and factors affecting flora composition. CRC Critical Reviews in Food Science and Nutrition. 1977;8(3):229-336.  https://doi.org/10.1080/10408397709527224
  19. Franks AH, Harmsen HJ, Raangs GC, Jansen GJ, Schut F, Welling GW. Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Applied and Environmental Microbiology. 1998;64(9):3336-3345. https://doi.org/10.1128/AEM.64.9.3336-3345.1998
  20. Turnbaugh PJ, Gordon JI. The core gut microbiome, energy balance and obesity. Journal of Physiology. 2009;587(Pt 17):4153-4158. https://doi.org/10.1113/jphysiol.2009.174136
  21. Deschasaux M, Bouter KE, Prodan A, Levin E, Groen AK, Herrema H, Tremaroli V, Bakker GJ, Attaye I, Pinto-Sietsma SJ, van Raalte DH, Snijder MB, Nicolaou M, Peters R, Zwinderman AH, Bäckhed F, Nieuwdorp M. Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography. Nature Medicine. 2018;24(10):1526-1531. https://doi.org/10.1038/s41591-018-0160-1
  22. Snijder MB, Galenkamp H, Prins M, Derks EM, Peters RJG, Zwinderman AH, Stronks K. Cohort profile: the Healthy Life in an Urban Setting (HELIUS) study in Amsterdam, The Netherlands. BMJ Open. 2017;7(12):e017873. https://doi.org/10.1136/bmjopen-2017-017873
  23. He Y, Wu W, Zheng HM, Li P, McDonald D, Sheng HF, Chen MX, Chen ZH, Ji GY, Zheng ZD, Mujagond P, Chen XJ, Rong ZH, Chen P, Lyu LY, Wang X, Wu CB, Yu N, Xu YJ, Yin J, Raes J, Knight R, Ma WJ, Zhou HW. Regional variation limits applications of healthy gut microbiome reference ranges and disease models. Nature Medicine. 2018;24(10):1532-1535. https://doi.org/10.1038/s41591-018-0164-x
  24. Balvers M, de Goffau M, van Riel N, van den Born BJ, Galenkamp H, Zwinderman K, Nieuwdorp M, Levin E. Ethnic variations in metabolic syndrome components and their associations with the gut microbiota: the HELIUS study. Genome Medicine. 2024;16(1):41.  https://doi.org/10.1186/s13073-024-01295-7
  25. Chen L, Zhang YH, Huang T, Cai YD. Gene expression profiling gut microbiota in different races of humans. Scientific Reports. 2016;6:23075. https://doi.org/10.1038/srep23075
  26. Gaulke CA, Sharpton TJ. The influence of ethnicity and geography on human gut microbiome composition. Nature Medicine. 2018;24(10):1495-1496. https://doi.org/10.1038/s41591-018-0210-8
  27. Bäckhed F, Roswall J, Peng Y, Feng Q, Jia H, Kovatcheva-Datchary P, Li Y, Xia Y, Xie H, Zhong H, Khan MT, Zhang J, Li J, Xiao L, Al-Aama J, Zhang D, Lee YS, Kotowska D, Colding C, Tremaroli V, Yin Y, Bergman S, Xu X, Madsen L, Kristiansen K, Dahlgren J, Wang J. Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. Cell Host & Microbe. 2015;17(5):690-703.  https://doi.org/10.1016/j.chom.2015.04.004
  28. Bogaert D, van Beveren GJ, de Koff EM, Lusarreta Parga P, Balcazar Lopez CE, Koppensteiner L, Clerc M, Hasrat R, Arp K, Chu MLJN, de Groot PCM, Sanders EAM, van Houten MA, de Steenhuijsen Piters WAA. Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites. Cell Host and Microbe. 2023;31(3):447-460.e6.  https://doi.org/10.1016/j.chom.2023.01.018
  29. Mitchell CM, Mazzoni C, Hogstrom L, Bryant A, Bergerat A, Cher A, Pochan S, Herman P, Carrigan M, Sharp K, Huttenhower C, Lander ES, Vlamakis H, Xavier RJ, Yassour M. Delivery Mode Affects Stability of Early Infant Gut Microbiota. Cell Reports. Medicine. 2020;1(9):100156. https://doi.org/10.1016/j.xcrm.2020.100156
  30. Yassour M, Vatanen T, Siljander H, Hämäläinen AM, Härkönen T, Ryhänen SJ, Franzosa EA, Vlamakis H, Huttenhower C, Gevers D, Lander ES, Knip M; DIABIMMUNE Study Group; Xavier RJ. Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Science Translational Medicine. 2016;8(343):343ra81. https://doi.org/10.1126/scitranslmed.aad0917
  31. Rodríguez JM, Murphy K, Stanton C, Ross RP, Kober OI, Juge N, Avershina E, Rudi K, Narbad A, Jenmalm MC, Marchesi JR, Collado MC. The composition of the gut microbiota throughout life, with an emphasis on early life. Microbial Ecology in Health and Disease. 2015;26:26050. https://doi.org/10.1126/scitranslmed.aad0917
  32. Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen HB, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal EG, Wang J, Guarner F, Pedersen O, de Vos WM, Brunak S, Doré J; MetaHIT Consortium; Antolín M, Artiguenave F, Blottiere HM, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner KU, Friss C, van de Guchte M, Guedon E, Haimet F, Huber W, van Hylckama-Vlieg J, Jamet A, Juste C, Kaci G, Knol J, Lakhdari O, Layec S, Le Roux K, Maguin E, Mérieux A, Melo Minardi R, M’Rini C, Muller J, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G, Weissenbach J, Ehrlich SD, Bork P. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174-180.  https://doi.org/10.1038/nature09944
  33. Rodríguez JM, Murphy K, Stanton C, Ross RP, Kober OI, Juge N, Avershina E, Rudi K, Narbad A, Jenmalm MC, Marchesi JR, Collado MC. The composition of the gut microbiota throughout life, with an emphasis on early life. Microbial Ecology in Health and Disease. 2015;26:26050. https://doi.org/10.3402/mehd.v26.26050
  34. Ragonnaud E, Biragyn A. Gut microbiota as the key controllers of “healthy” aging of elderly people. Immunity and Ageing. 2021;18(1):2.  https://doi.org/10.1186/s12979-020-00213-w
  35. Corrêa-Oliveira R, Fachi JL, Vieira A, Sato FT, Vinolo MA. Regulation of immune cell function by short-chain fatty acids. Clinical and Translational Immunology. 2016;5(4):e73.  https://doi.org/10.1038/cti.2016.17
  36. Di Renzo L, Gualtieri P, Romano L, Marrone G, Noce A, Pujia A, Perrone MA, Aiello V, Colica C, De Lorenzo A. Role of Personalized Nutrition in Chronic-Degenerative Diseases. Nutrients. 2019;11(8):1707. https://doi.org/10.3390/nu11081707
  37. Zeevi D, Korem T, Zmora N, Israeli D, Rothschild D, Weinberger A, Ben-Yacov O, Lador D, Avnit-Sagi T, Lotan-Pompan M, Suez J, Mahdi JA, Matot E, Malka G, Kosower N, Rein M, Zilberman-Schapira G, Dohnalová L, Pevsner-Fischer M, Bikovsky R, Halpern Z, Elinav E, Segal E. Personalized Nutrition by Prediction of Glycemic Responses. Cell. 2015;163(5):1079-1094. https://doi.org/10.1016/j.cell.2015.11.001
  38. Gospodarik AV, Prokhorova ND, Bespyatykh YuA. Selection of donors for fecal microbiota transplantation: involuntary screening of public health. ORGZDRAV: novosti, mneniya, obuchenie. Vestnik VShOUZ. 2024;10(1):92-103.  https://doi.org/10.33029/2411-8621-2024-10-1-92-103

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