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Prokhorova N.D.
Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency
Gospodarik A.V.
Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency
Bespyatykh Yu.A.
Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency
Gut microbiota: role in human health and potential for personalized medicine
Journal: Russian Journal of Evidence-Based Gastroenterology. 2024;13(4): 81‑88
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To cite this article:
Prokhorova ND, Gospodarik AV, Bespyatykh YuA. Gut microbiota: role in human health and potential for personalized medicine. Russian Journal of Evidence-Based Gastroenterology.
2024;13(4):81‑88. (In Russ.)
https://doi.org/10.17116/dokgastro20241304181
The relationship between gut microbiota and human health is increasingly recognized as pivotal in medical research and clinical practice. The gut microbiota performs essential physiological functions, from nutrient metabolism to immune regulation, underscoring its importance for lifelong health. Disruptions in microbiota composition have been linked to various pathological conditions, including metabolic syndrome, inflammatory bowel disease, and neurodegenerative disorders.
To analyze current data on the role of gut microbiota in maintaining human health and explore its potential applications in personalized medicine.
Current research highlights the dynamic and variable nature of the gut microbiota, with differences observed across age, geographic regions, and ethnicities. The balance between major bacterial phyla, such as Bacillota and Bacteroidetes, is particularly important in determining susceptibility to metabolic disorders. Advances in sequencing technologies have significantly improved the understanding of microbiota composition and function. Fecal microbiota transplantation (FMT) shows promise for treating several diseases, though challenges in donor selection remain.
The gut microbiota plays a critical role in maintaining human health and homeostasis. Personalized medicine, informed by microbiota composition, may become a cornerstone of future medical treatments. Continued research is essential to establish normal ranges of microbial diversity and develop therapeutic interventions to preserve or restore it.
Keywords:
Authors:
Prokhorova N.D.
Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency
Gospodarik A.V.
Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency
Bespyatykh Yu.A.
Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency
Received:
10.10.2024
Accepted:
18.10.2024
List of references:
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