Генетические исследования преэклампсии

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Преэклампсия — акушерское осложнение, которое является одной из основных причин материнской и перинатальной заболеваемости и смертности. В настоящее время этиология данной патологии до конца не изучена, однако неоспоримой является роль генетических факторов в развитии преэклампсии, которая составляет, по данным различных авторов, более 50%. Генетические основы преэклампсии активно изучаются во всем мире, однако полученные результаты зачастую фрагментарны и не подтверждаются при проведении воспроизведенных исследований в различных популяциях, что обусловливает актуальность дальнейшего изучения генетических детерминант в формировании данного осложнения беременности. В данной статье представлен обзор русскоязычных и зарубежных публикаций результатов полногеномных, репликативных и/или ассоциативных исследований о роли генетических факторов в развитии преэклампсии, опубликованных за период с 2009 г. по настоящее время в электронных базах данных PubMed, PubMedCentral и eLIBRARY и в каталоге полногеномных исследований (GWAS Catalog).

Ключевые слова:

преэклампсия

GWAS

гены вазоактивных гормонов

гены факторов роста

гены метаболизма

гены цитокинов

Авторы:

Абрамова М.Ю.

ФГАОУ ВО «Белгородский государственный национальный исследовательский университет» Минобрнауки России

ORCID: 0000-0002-1406-2515

Чурносов М.И.

ФГАОУ ВО «Белгородский государственный национальный исследовательский университет» Минобрнауки России

ORCID: 0000-0003-1254-6134

Дата поступления:

28.02.2022

Дата принятия в печать:

29.03.2022

Список литературы:

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