Роль транскрипционных факторов в патогенетических процессах, связанных с шизофренией

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Шизофрения — тяжелое психическое заболевание, в этиологию и патогенез которого значительный вклад вносят наследственные факторы. Анализ полногеномных ассоциаций показывает, что большинство генетических вариантов, ассоциированных с высоким риском развития шизофрении, расположено в регуляторных областях генов. В кратком обзоре представлены данные об общей структуре основных регуляторных областей генов. Основное внимание уделено энхансерам — участкам генома, усиливающим активность гена. Подробно рассматривается участие транскрипционных факторов, взаимодействующих с регуляторными областями генов, в различных молекулярных и клеточных процессах, нарушение которых ассоциировано с патогенезом шизофрении.

Ключевые слова:

шизофрения

GWAS

TWAS

энхансеры

транскрипционные факторы

Авторы:

Карпов Д.С.

ФГБНУ «Научный центр психического здоровья»

ORCID: 0000-0001-5203-0787

Мариловцева Е.В.

ФГБНУ «Научный центр психического здоровья»

ORCID: 0000-0003-1118-9470

Голимбет В.Е.

ФГБНУ «Научный центр психического здоровья»

ORCID: 0000-0002-9960-7114

Дата поступления:

26.06.2024

Дата принятия в печать:

09.07.2024

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