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Shcherbakov V.I.

Federal Research Center for Fundamental and Translational Medicine

Pozdnyakov I.M.

Novosibirsk State Medical University

Shirinskaya A.V.

Novosibirsk City Clinical Perinatal Center

Volkov M.V.

Federal Research Center for Fundamental and Translational Medicine

Kucherenko S.G.

Novosibirsk State Medical University

High mobility group protein B1 (HMGB1) and the potential for inflammation amplification in preeclampsia and threatened preterm labor

Authors:

Shcherbakov V.I., Pozdnyakov I.M., Shirinskaya A.V., Volkov M.V., Kucherenko S.G.

More about the authors

Journal: Russian Journal of Human Reproduction. 2024;30(5): 82‑88

DOI: 10.17116/repro20243005182

Read: 1330 times

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Table of contents

HIGH MOBILITY GROUP PROTEIN B1 (HMGB1) AND THE POTENTIAL FOR INFLAMMATION AMPLIFICATION IN PREECLAMPSIA AND THREATENED PRETERM LABOR
HIGH MOBILITY GROUP PROTEIN B1 (HMGB1) AND THE POTENTIAL FOR INFLAMMATION AMPLIFICATION IN PREECLAMPSIA AND THREATENED PRETERM LABOR

To cite this article:

Shcherbakov VI, Pozdnyakov IM, Shirinskaya AV, Volkov MV, Kucherenko SG. High mobility group protein B1 (HMGB1) and the potential for inflammation amplification in preeclampsia and threatened preterm labor. Russian Journal of Human Reproduction. 2024;30(5):82‑88. (In Russ.)
https://doi.org/10.17116/repro20243005182

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

AIM OF THE STUDY

Was to study the level of allarmines and other pro-inflammatory molecules as possible inflammatory amplifiers in preeclampsia and the threat of premature birth.

MATERIAL AND METHODS

The study included three groups of pregnant women: the 1st group — pregnant women with preeclampsia; the 2nd group — pregnant women with the threat of premature birth; the control group — women with physiological pregnancy. The levels of highly mobile group B1 protein, uric acid, albumin, interferon-γ, stable NO products, lactate dehydrogenase, and lactate in blood serum were determined.

RESULTS

In pregnant women with preeclampsia and the threat of premature birth, an increase in the level of protein B1 of the highly mobile group was found. Preeclampsia also shows elevated levels of interferon-γ, uric acid, lactate dehydrogenase and lactate. The albumin level decreases especially significantly in the period 1 day prior to cesarean section. The level of stable NO products did not significantly differ from the control.

CONCLUSIONS

The increase in the classical alarmin, high-mobility group B1 protein, found by us in preeclampsia and the threat of premature birth may increase inflammation in these pathologies. Increased levels of interferon-γ, lactate, and uric acid in combination may contribute to the progression of preeclampsia.

Keywords:

preeclampsia
premature birth
danger signals
inflammation

Authors:

Shcherbakov V.I.

Federal Research Center for Fundamental and Translational Medicine

Pozdnyakov I.M.

Novosibirsk State Medical University

Shirinskaya A.V.

Novosibirsk City Clinical Perinatal Center

Volkov M.V.

Federal Research Center for Fundamental and Translational Medicine

Kucherenko S.G.

Novosibirsk State Medical University

Received:

01.10.2023

Accepted:

29.05.2024

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