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Aksenova M.G.

Avtsyn Research Institute of Human Morphology of the Petrovsky Russian Scientific Center of Surgery

Nizyaeva N.V.

Avtsyn Research Institute of Human Morphology of the Petrovsky Russian Scientific Center of Surgery

Kulikov I.A.

Vidnovsky Perinatal Center

Doronin S.N.

Vidnovsky Perinatal Center

Tikhonova N.B.

Avtsyn Research Institute of Human Morphology of the Petrovsky Russian Scientific Center of Surgery

Bochkov V.V.

Avtsyn Research Institute of Human Morphology of the Petrovsky Russian Scientific Center of Surgery

Epigenetic regulation in the placenta in case of impaired trophoblast invasion (a review)

Authors:

Aksenova M.G., Nizyaeva N.V., Kulikov I.A., Doronin S.N., Tikhonova N.B., Bochkov V.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2024;30(6): 45‑54

DOI: 10.17116/repro20243006145

Views: 450

Downloaded: 18

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To cite this article:

Aksenova MG, Nizyaeva NV, Kulikov IA, Doronin SN, Tikhonova NB, Bochkov VV. Epigenetic regulation in the placenta in case of impaired trophoblast invasion (a review). Russian Journal of Human Reproduction. 2024;30(6):45‑54. (In Russ.)
https://doi.org/10.17116/repro20243006145

 
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The review presents the function of epigenetic regulation in abnormal trophoblast invasion, concomitant with preeclampsia and (placenta acreta spectrum, PAS). We have described the current progress regarding the effects of DNA methylation, non-coding RNAs (with special emphasis on long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) and less significant posttranslational modifications of histones to processes leading to normal development or abnormal trophoblast invasion. The pros and cons of studying the epigenetic mechanisms of trophoblast invasion in placental animals such as mice and rats, are considered. A search in the scientific literature for results of differentially expressed genes in extraembryonic tissues revealed specific methylation of gene promoters in the syncytiotrophoblast and extravillous trophoblast. In the section of histone modifications, the functional role of the mark of gene silence, a trimethylated form of constitutive heterochromatin H3K4me3, was considered. For non-coding RNAs, both the commonality of participation in the biological processes of cancer metastasis and epithelial-mesenchymal transition, and the uniqueness of the invasive trophoblast for some of them, have been established. The epigenetic community of the biological processes of invasive placentation and cancer metastasis was discussed. The review attempts to identify unusual aspects of epigenetic regulation in disorders of trophoblast invasion and link them to the specialized biological needs of this organ.

Keywords:

trophoblast invasion
epigenetics
methylation
non-coding RNAs
preeclampsia
PAS

Authors:

Aksenova M.G.

Avtsyn Research Institute of Human Morphology of the Petrovsky Russian Scientific Center of Surgery

Nizyaeva N.V.

Avtsyn Research Institute of Human Morphology of the Petrovsky Russian Scientific Center of Surgery

Kulikov I.A.

Vidnovsky Perinatal Center

Doronin S.N.

Vidnovsky Perinatal Center

Tikhonova N.B.

Avtsyn Research Institute of Human Morphology of the Petrovsky Russian Scientific Center of Surgery

Bochkov V.V.

Avtsyn Research Institute of Human Morphology of the Petrovsky Russian Scientific Center of Surgery

Received:

07.07.2024

Accepted:

01.10.2024

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