The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Fedorenko V.A.

Moscow Regional Research Institute of Obstetrics and Gynecology

Me’lnikov A.P.

Moscow Regional Research Institute of Obstetrics and Gynecology

Fibrinolysis disorders in obstetric and gynecologic practice

Authors:

Fedorenko V.A., Me’lnikov A.P.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2022;22(6): 18‑26

DOI: 10.17116/rosakush20222206118

Views: 2816

Downloaded: 47

Download PDF (RU)
Contact the author
Table of contents

FIBRINOLYSIS DISORDERS IN OBSTETRIC AND GYNECOLOGIC PRACTICE
FIBRINOLYSIS DISORDERS IN OBSTETRIC AND GYNECOLOGIC PRACTICE

To cite this article:

Fedorenko VA, Me’lnikov AP. Fibrinolysis disorders in obstetric and gynecologic practice. Russian Bulletin of Obstetrician-Gynecologist. 2022;22(6):18‑26. (In Russ.)
https://doi.org/10.17116/rosakush20222206118

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Modern approach to the diagnosis of microcirculatory diso­rders in obstetrics. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):30-35
Pecu­liarities of placental microRNA expression in patients with preeclampsia and fetal growth restriction. Russian Bulletin of Obstetrician-Gynecologist. 2024;(6):14-25
Rare case of SARS-CoV-2 and Acinetobacter Baumannii complications after reinfection of SARS-CoV-2. Russian Journal of Preventive Medi­cine. 2024;(5):81-83
Clinical and anatomical rationale for the effe­ctiveness of treatment of phle­gmon of the floor of the oral cavity and deep cellular spaces of the neck complicated with sepsis. Russian Journal of Operative Surgery and Clinical Anatomy. 2024;(2):19-25
Influence of sevo­flurane on neutrophils in patients with sepsis. Russian Journal of Anesthesiology and Reanimatology. 2024;(5):50-57
High mobi­lity group protein B1 (HMGB1) and the pote­ntial for inflammation amplification in preeclampsia and threatened preterm labor. Russian Journal of Human Reproduction. 2024;(5):82-88
Neurometabolic therapy with Cere­brolysin in patients with sepsis-associated ence­phalopathy. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):46-54
Nutritional support for sepsis: is there a single concept?. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):70-78
A bala­nce between surgical mana­gement and therapy in a patient with severe sternomediastinitis complicated by heart failure and refractory septic shock. Piro­gov Russian Journal of Surgery. 2024;(12-2):166-172
The role of neutrophils in the mechanisms of sepsis. Russian Journal of Archive of Pathology. 2024;(6):82-91

The review presents modern data concerning the fibrinolysis system, the possibilities of laboratory examination of its dysfunction and their pathogenetic significance in obstetric-gynecological pathology as well as the possibilities of drug correction of these dysfunctions.

Keywords:

fibrinolysis
laboratory methods of fibrinolysis system investigation
preeclampsia
amniotic fluid embolism
sepsis

Authors:

Fedorenko V.A.

Moscow Regional Research Institute of Obstetrics and Gynecology

Me’lnikov A.P.

Moscow Regional Research Institute of Obstetrics and Gynecology

Received:

16.11.2022

Accepted:

17.01.2022

List of references:

  1. Lippi G, Favaloro EJ. Laboratory hemostasis: from biology to the bench. Clin Chem Lab Med. 2018;56:7:1035-1045. https://doi.org/10.1515/cclm-2017-1205
  2. Jespersen J. Pathophysiology and clinical aspects of fibrinolysis and inhibition of coagulation. Experimental and clinical studies with special reference to women on oral contraceptives and selected groups of thrombosis prone patients. Dan Med Bull. 1988;35:1:1-33. 
  3. Tripodi A. Tests of coagulation in liver disease. Clin Liver Dis. 2009;13:55-61.  https://doi.org/10.1016/j.cld.2008.09.002
  4. Alessi MC, Morange P, Juhan-Vague I. Fat cell function and fibrinolysis. Horm Metab Res. 2000;32:504-508.  https://doi.org/10.1055/s-2007-978677
  5. Glise L, Larsson P, Jern S, Borén J, Levin M, Ny T, Fogelstrand P, Bergh N. Disturbed laminar blood flow causes impaired fibrinolysis and tndothelial fibrin deposition in vivo. Thromb Haemost. 2019;119:2:223-233.  https://doi.org/10.1055/s-0038-1676638
  6. Horbach DA, van Oort E, Lisman T, Meijers JC, Derksen RH, de Groot PG. β2-glycoprotein I is proteolytically cleaved in vivo upon activation of fibrinolysis. Thromb Haemost. 1999;81:87-95.  https://doi.org/10.1055/s-0037-1614424
  7. Larsen JB, Hvas AM. Fibrinolytic alterations in sepsis: biomarkers and future treatment targets. Semin Thromb Hemost. 2021;47:5:589-600.  https://doi.org/10.1055/s-0041-1725096
  8. Clare E Hyatt, Benjamin M Brainard. Point-of-care assessment of coagulation. Top Companion Anim Med. 2016;31:1:11-17.  https://doi.org/10.1053/j.tcam.2016.05.002
  9. Ekelund K, Hanke G, Stensballe J, Wikkelsoe A, Krebs Albrechtsen C, Afshari A. Hemostatic resuscitation in postpartum hemorrhage — a supplement to surgery. Acta Obstet Gynecol Scand. 2015;94:7:680-692.  https://doi.org/10.1111/aogs.12607
  10. Colin Longstaff. Measuring fibrinolysis: from research to routine diagnostic assays. J Thromb Haemost. 2018;16:4:652-662.  https://doi.org/10.1111/jth.13957
  11. Hemker HC, Giesen P, Al Dieri R, Regnault V, de Smedt E, Wagenvoord R, Lecompte T, Béguin S. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb. 2003;33:4-15.  https://doi.org/10.1159/000071636
  12. He S, Antovic A, Blomback M. A simple and rapid laboratory method for determination of haemostasis potential in plasma. II. Modifications for use in routine laboratories and research work. Thromb Res. 2001;103:5:355-361.  https://doi.org/10.1016/s0049-3848(01)00332-2
  13. Hellgren M. Hemostasis during normal pregnancy and puerperium. Thrombosis and Hemostasis. 2003,29:2:125-130.  https://doi.org/10.1055/s-2003-38897
  14. Curnow J, Favaloro EJ, Lippi G. The overall hemostatic potential (OHP) assay. Methods Mol Biol. 2017;1646:523-531.  https://doi.org/10.1007/978-1-4939-7196-1_38
  15. Budkowskaa M, Lebieckab A, Marcinowskac Z, Woźniakd J, Jastrzębskaa M, Dołęgowskae B. The circadian rhythm of selected parameters of the hemostasis system in healthy people. Thrombosis Research. 2019;182:79-88.  https://doi.org/10.1016/j.thromres.2019.08.015
  16. Siddqui N, Shoeb M, Bose S. Fibrinolytic activity of blood and its determinants in healthy medical students. J Clin Diagn Res. 2015;9:6:CC05-7.  https://doi.org/10.7860/JCDR/2015/12483.6017
  17. Sheppard BL, Bonnar J. Fibrinolysis in decidual spiral arteries in late pregnancy. Thromb Haemostas. 1978;39:751-758. 
  18. Roullet S, Labrouche S, Mouton C, Quinart A, Nouette-Gaulain K, Laurent C, Freyburger G. Lysis timer: a new sensitive tool to diagnose hyperfibrinolysis in liver transplantation. J Clin Pathol. 2019;72:1:58-65.  https://doi.org/10.1136/jclinpath-2018-205280
  19. Boncela J, Przygodzka P, Wyroba E, Papiewska-Pajak I, Cierniewski CS. Secretion of serpinB2 from endothelial cells activated with inflammatory stimuli. Exp. Cell Res. 2013;319:1213-1219. https://doi.org/10.1016/j.yexcr.2013.02.018
  20. Pavord EdS, Hunt B, Ramsay M. Normal hematological changes during pregnancy and the puerperium. The Obstetric hematology manual. Cambridge university press. Cambridge. 2010;3-11. 
  21. Ferro D, Violi F, Quintarelli, C, Sebastianelli A, D’Amelio R, Zichella L, Balsano F. Fibrinolytic balance and lupus anticoagulant in patients with repeated spontaneous fetal loss. Br Med J. 1992;305:504-505.  https://doi.org/10.1136/bmj.305.6852.504
  22. Atsumi T, Khamashta, MA, Andujar, C, Leandro MJ, Amengual O, Ames PR, Hughes GR. Elevated plasma lipoprotein(a) level and its association with impaired fibrinolysis in patients with antiphospholipid syndrome. J Rheumatol. 1998;25:69-73. 
  23. Curnow JL, Morel-Kopp, MC, Roddie C, Aboud M, Ward CM. Reduced fibrinolysis and increased fibrin generation in hypercoagulable patients using the overall hemostatic potential assay. J Thromb Haemost. 2007;5:528-534.  https://doi.org/10.1111/j.1538-7836.2007.02362.x
  24. Nilsson TK, Lofvenberg E. Decreased fibrinolytic capacity and increased von Willebrand factor levels as indicators of endothelial cell dysfunction in patients with lupus anticoagulants. Clin Rheumatol. 1989;8:58-63.  https://doi.org/10.1007/BF02031071
  25. Kolev K, Gombas, J, Varadi B, Skopál J, Mede K, Pitlik E, Nagy Z, Machovich R. Immunoglobulin G from patients with antiphospholipid syndrome impairs the fibrin dissolution with plasmin. Thromb Haemost. 2002;87:502-508.  https://doi.org/10.1055/S-0037-1613031
  26. Cesarman-Maus G, Rios-Luna NP, Deora AB, Huang B, Villa R, del Carmen Cravioto M, Alarcón-Segovia D, Sánchez-Guerrero J, Hajjar KA. Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome. Blood. 2006;107:4375-4382. https://doi.org/10.1182/blood-2005-07-2636
  27. Tassies D, Espinosa G, Munoz-Rodriguez F, Freire C, Cervera R, Monteagudo J, Maragall S, Escolar G, Ingelmo M, Ordinas A, Font J, Reverter JC. The 4G/5G polymorphism of the type 1 plasminogen activator inhibitor gene and thrombosis in patients with antiphospholipid syndrome. Arthritis Rheum. 2000;43:2349-2358. https://doi.org/10.18097/pbmc20146001072
  28. Pinheiro MB, Gomes KB, Dusse LM. Fibrinolytic system in preeclampsia. Clin Chim Acta. 2013;416:67-71.  https://doi.org/10.1016/j.cca.2012.10.060
  29. Lalic-Cosic S, Dopsaj V, Kovac M, Pruner I, Littmann K, Mandic-Markovic V, Mikovic Z, Antovic A. Evaluation of global haemostatic assays and fibrin structure in patients with pre-eclampsia. Int J Lab Hematol. 2020;00:1-9.  https://doi.org/10.1111/ijlh.13183
  30. Mansouritorghabeh H, de Laat B, Roest M. Current methods of measuring platelet activity: pros and cons. Blood Coagul Fibrinolysis. 2020;31:7:426-433.  https://doi.org/10.1097/MBC.0000000000000941
  31. Martínez-Zamora MA, Tassies D, Carmona F, Espinosa G, Cervera R, Reverter JC, Balasch J. Clot lysis time and thrombin activatable fibrinolysis inhibitor in severe preeclampsia with or without associated antiphospholipid antibodies. J Reprod Immunol. 2010;86:2:133-140.  https://doi.org/10.1016/j.jri.2010.05.002
  32. Annecke T, Geisenberger T, Kürzl R, Penning R, Heindl B. Algorithm-based coagulation management of catastrophic amniotic fluid embolism. Blood Coagul Fibrinolysis. 2010;21:95-100.  https://doi.org/10.1097/MBC.0b013e328332cfe2
  33. Fudaba M, Tachibana D, Misugi T, Nakano A, Koyama M. Excessive fbrinolysis detected with thromboelastography in a case of amniotic fuid embolism: fbrinolysis may precede coagulopathy. J Thromb Thrombolysis. 2021;51:3:818-820.  https://doi.org/10.1007/s11239-020-02237-x
  34. Oda T, Tamura N, Ide R, Itoh T, Horikoshi Y, Matsumoto M, Narumi M, Kohmura-Kobayashi Y, Furuta-Isomura N, Yaguchi C, Uchida T, Suzuki K, Itoh H, Kanayama N. Consumptive coagulopathy involving amniotic fluid embolism: the importance of earlier assessments for interventions in critical care. Critical Care Med. 48:12:e1251-e1259. https://doi.org/10.1097/CCM.0000000000004665
  35. Oda T, Tamura N, Shen Y, Kohmura-Kobayashi Y, Furuta-Isomura N, Yaguchi C, Uchida T, Suzuki K, Itoh H, Kanayama N. Amniotic fluid as a potent activator of blood coagulation and platelet aggregation: Study with rotational thromboelastometry Thrombosis Res. 2018;172:142-149.  https://doi.org/10.1016/j.thromres.2018.11.001
  36. Schröder L, Hellmund A, Gembruch U, Merz W. Amniotic fuid embolism-associated coagulopathy: a single-center observational study. Arch Gynecol Obstet. 2020;301:4:923-929.  https://doi.org/10.1007/s00404-020-05466-w
  37. Butwick AJ. Postpartum hemorrhage: wherefore art thou, hyperfibrinolysis? Anesth Analg. 2020;131:5:1370-1372. https://doi.org/10.1213/ANE.0000000000004881
  38. McLintock C. Prevention and treatment of postpartum hemorrhage: focus on hematological aspects of management. Hematol Am Soc Hematol Educ Program. 2020;2020;1:542-546.  https://doi.org/10.1182/hematology.2020000139
  39. Karlsson O, Jeppsson A, Hellgrenc M. Major obstetric haemorrhage: monitoring with thromboelastography, laboratory analyses or both? Int J Obstet Anesthes. 2014;23:10-17.  https://doi.org/10.1016/j.ijoa.2013.07.003
  40. Veen CSB, Huisman EJ? Cnossen MH, Kom-Gortat R, Rijken DC, Leebeek FWG, Maat MPM, Kruip MJHA. Evaluation of thromboelastometry, thrombin generation and plasma clot lysis time in patients with bleeding of unknown cause: A prospective cohort study. Haemophilia. 2020;26:3:e106-e115. https://doi.org/10.1111/hae.13991
  41. Arnolds DE, Scavone BM. Thromboelastographic assessment of fibrinolytic activity in postpartum hemorrhage: a retrospective single-center observational study. Anesth Analg. 2020;131:5:1373-1379. https://doi.org/10.1213/ANE.0000000000004796
  42. Rybo G. Plasminogen activators in the endometrium. II. Clinical aspects. Acta Obst et Gynec Scand. 1966;45:429-450.  https://doi.org/10.3109/00016346609158461
  43. Mikovich D, Mel’nikov A.P. Congenital defects in blood coagulation factors and obstetric complications. Klinicheskaya meditsina. 2020;98:11-12:729-738. (In Russ.).
  44. Yamanaka A, Kimura F, Yoshida T, Kita N, Takahashi K, Kushima R, Murakmai T. Dysfunctional coagulation and fibrinolysis systems due to adenomyosis is a possible cause of thrombosis and menorrhagia. Eur J Obstet Gynecol Reprod Biol. 2016;204:99-103.  https://doi.org/10.1016/j.ejogrb.2016.07.499
  45. Zorio E, Gilabert-Estellés J, España F, Ramón L, Cosín R, Estellés A. Fibrinolysis: the key to new pathogenetic mechanisms. Curr Med Chem. 2008;15:9:923-929.  https://doi.org/10.2174/092986708783955455
  46. Targher G, Zoppini G, Bonora E, Moghetti P. Hemostatic and fibrinolytic abnormalities in polycystic ovary syndrome. Semin Thromb Hemost. 2014;40:5:600-618.  https://doi.org/10.1055/s-0034-1384512
  47. Binette TM, Taylor FB Jr, Peer G, Bajzar L. Thrombin-thrombomodulin connects coagulation and fibrinolysis: more than an in vitro phenomenon. Blood. 2007;110:3168-3175. https://doi.org/10.1182/blood-2007-03-078824
  48. Armando Tripodi. Hemostasis abnormalities in cirrhosis. Curr Opin Hematol. 2015;22:5:406-412.  https://doi.org/10.1097/MOH.0000000000000164
  49. Juhan-Vague I, Alessi MC, Joly P, Thirion X, Vague P, Declerck PJ, Serradimigni A, Collen D. Plasma plasminogen activator inhibitor I in angina pectoris. Influence of plasma insulin and acute-phase response. Arteriosclerosis. 1989;9:362-367.  https://doi.org/10.1161/01.atv.9.3.362
  50. Liu Z, Liu C, Zhong M, Yang F, Chen H, Kong W, Lv P, Chen W, Yao Y, Cao Q, Zhou H. Changes in coagulation and fibrinolysis in post-cesarean section parturients treated with low molecular weight heparin. Clin Appl Thromb Hemost. 2020;26.  https://doi.org/10.1177/1076029620978809
  51. Moatti Z, Gupta M, Yadava R, Thamban S. A review of stroke and pregnancy: incidence, management and prevention. Eur J Obstet Gynecol Reprod Biol. 2014;181:20-27.  https://doi.org/10.1016/j.ejogrb.2014.07.024
  52. Jaigobin C. Stroke and pregnancy. Stroke. 2000;31:12:2948-2951. https://doi.org/10.1161/01.str.31.12.2948
  53. Whiting P, Al M, Westwood M, Corro Ramos I, Ryder S, Armstrong N, Misso K, Ross J, Severens J, Kleijnen J. Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis. Health Technol Assess. 2015;19:58:1-228, v-vi.  https://doi.org/10.3310/hta19580
  54. Park R, Song J, Soo SA. Elevated levels of activated and inactivated thrombin-activatable fibrinolysis inhibitor in patients with sepsis. An. Korean J Hematol. 2010;45:264-268.  https://doi.org/10.5045/kjh.2010.45.4.264
  55. Bonnar J, Guillebaud J, Kasonde JM, Sheppard BL. Clinical applications of fibrinolytic inhibition in gynaecology. J Clin Pathol. 33, Suppl (Roy Coll Path). 1980;14:55-59. 
  56. Ducloy-Bouthors A-S, Jude B, Duhamel A, Broisin F, Huissoud C, Keita-Meyer H, Mandelbrot L, Tillouche N, Fontaine S, Le Goueff F, Depret-Mosser S, Vallet B, EXADELI Study Group; Sophie Susen. High-dose tranexamic acid reduces blood loss in postpartum haemorrhage. Crit Care Lond Engl. 2011;15:R117. https://doi.org/10.1186/cc10143
  57. Leonhardt G. Thrombolytic therapy in pregnancy. J Thromb Thrombolysis. 2006;21:3:271-276.  https://doi.org/10.1007/s11239-006-5709-z
  58. Demchuk AM. Yes, intravenous thrombolysis should be administered in pregnancy when other clinical and imaging factors are favorable. Stroke. 2013;44:3:864-865.  https://doi.org/10.1161/STROKEAHA.111.000134
  59. Einhaupl K. EFNS guideline on the treatment of cerebral venous and sinus thrombosis. Eur J Neurol. 2006;13:553-559.  https://doi.org/10.1111/j.1468-1331.2010.03011.x
  60. Ishihara T, Nogami K, Onishi T, Ogiwara K, Ochi S, Yamazaki M, Shima M. Hemostatic function on hyper-fibrinolytic disseminated intravascular coagulation. Pediatr Int. 2019;61:9.  https://doi.org/10.1111/ped.13919
  61. Rijken DC, Hoegee-de NE, Jie AF, Atsma DE, Schalij MJ, Nieuwenhuizen W. Development of a new test for the global fibrinolytic capacity in whole blood. J Thromb Haemost. 2008;6:1:151-157.  https://doi.org/10.1111/j.1538-7836.2007.02816.x
  62. Barinov SV, Dolgikh VT, Medyannikova IV. Pathogenetically substantiated prevention of adverse pregnancy outcomes in women with gestational coagulopathy. Vestnik RAMN. 2014;5-6:102-106. (In Russ.).
  63. Buriko Y, Hess RS, Pfeifer JM, Silverstein DC. Utility of the Sonoclot analyzer to assess hyperfibrinolysis in dogs. Vet Clin Pathol. 2021;50:178-183.  https://doi.org/10.1111/vcp.12953
  64. Andrew G. Burton, Karl E. Jandrey. Use of Thromboelastography in Clinical Practice. Vet Clin North Am Small Anim Pract. 2020 Nov;50:6:1397-1409. https://doi.org/10.1016/j.cvsm.2020.08.001
  65. Bonnard T, Law LS, Tennant Z, Hagemeyer CE. Development and validation of a high throughput whole blood thrombolysis plate assay. Sci Rep 2017;7:1:2346. https://doi.org/10.1038/s41598-017-02498-2
  66. Chitlur M. Challenges in the laboratory analyses of bleeding disorders. Thromb Res. 2012;130:1:1-6.  https://doi.org/10.1016/j.thromres.2012.03.011

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.