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Lisitsyna O.I.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Romanov A.Yu.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Syrkasheva A.G.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Makarova N.P.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Dolgushina N.V.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Impact of trophectoderm biopsy on the course of pregnancy and obstetric outcomes

Authors:

Lisitsyna O.I., Romanov A.Yu., Syrkasheva A.G., Makarova N.P., Dolgushina N.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2025;31(3): 63‑69

DOI: 10.17116/repro20253103163

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Table of contents

IMPACT OF TROPHECTODERM BIOPSY ON THE COURSE OF PREGNANCY AND OBSTETRIC OUTCOMES
IMPACT OF TROPHECTODERM BIOPSY ON THE COURSE OF PREGNANCY AND OBSTETRIC OUTCOMES

To cite this article:

Lisitsyna OI, Romanov AYu, Syrkasheva AG, Makarova NP, Dolgushina NV. Impact of trophectoderm biopsy on the course of pregnancy and obstetric outcomes. Russian Journal of Human Reproduction. 2025;31(3):63‑69. (In Russ.)
https://doi.org/10.17116/repro20253103163

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

THE AIM OF THE STUDY

To assess the possible impact of trophectoderm biopsy on obstetric and perinatal outcomes of pregnancies resulting from the transfer of a thawed embryo in assisted reproductive technology programs.

MATERIAL AND METHODS

A retrospective single-center study was conducted, including analysis of medical records and a telephone survey of patients with confirmed clinical pregnancy after single thawed embryo transfer in 2020—2021. The possible impact of trophectoderm biopsy performed during preimplantation genetic testing for aneuploidies (PGT-A) on the course of pregnancy, obstetric and perinatal outcomes was analyzed. The study included data from 190 patients: 95 patients in the PGT-A group and 95 in the control group.

RESULTS

Isthmic-cervical insufficiency was observed more frequently in the PGT-A group (OR=2.54; 95% CI 1.04–6.21, p=0.034). A borderline statistically significant increase in placenta previa incidence was also noted (OR=6.34; 95% CI 0.75–53.69, p=0.054). No statistically significant differences were found between the PGT-A and control groups in terms of cesarean section rates, major obstetric syndromes, neonatal anthropometrics, or frequency of fetal malformations.

CONCLUSION

Trophectoderm biopsy during preimplantation genetic testing may increase the risk of placenta previa and accreta, as well as isthmic-cervical insufficiency. Additional studies are needed to confirm or refute these results.

Keywords:

trophectoderm biopsy
preimplantation genetic testing (PGT)
assisted reproductive technologies (ART)
in vitro fertilization (IVF)
obstetric outcomes
perinatal outcomes
placenta previa
placenta accreta
preeclampsia
cervical insufficiency (CI)

Authors:

Lisitsyna O.I.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Romanov A.Yu.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Syrkasheva A.G.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Makarova N.P.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Dolgushina N.V.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Received:

22.12.2023

Accepted:

12.02.2024

Close metadata

References:

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