Prognostic model of a patient with sepsis readiness to early mobilization with assistance

Ruslyakova I.A.; Shamsutdinova E.Z.; Shirokov K.I.; Ivanova N.E.

doi:https://doi.org/10.17116/kurort202510202126

Ruslyakova I.A.

North-Western State Medical University named after I. I. Mechnikov

SPIN RSCI: 3417-8804
ORCID: 0000-0003-1507-833X

Shamsutdinova E.Z.

North-Western State Medical University named after I. I. Mechnikov

ORCID: 0009-0003-5800-8697

Shirokov K.I.

North-Western State Medical University named after I. I. Mechnikov

ORCID: 0009-0008-4787-596X

Ivanova N.E.

V.A. Almazov National Medical Research Center

SPIN RSCI: 1854-7827
ORCID: 0000-0003-2790-0191

Prognostic model of a patient with sepsis readiness to early mobilization with assistance

Authors:

Ruslyakova I.A., Shamsutdinova E.Z., Shirokov K.I., Ivanova N.E.

More about the authors

Journal: Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;102(2): 26‑26

DOI: 10.17116/kurort202510202126

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To cite this article:

Ruslyakova IA, Shamsutdinova EZ, Shirokov KI, Ivanova NE. Prognostic model of a patient with sepsis readiness to early mobilization with assistance. Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;102(2):26‑26. (In Russ.)
https://doi.org/10.17116/kurort202510202126

Подписка 2026 Вопросы курортологии, физиотерапии и лечебной физической культуры (Problems of Balneology, Physiotherapy and Exercise Therapy)

Использование инфографики авторами научных работ

OBJECTIVE

To develop a prognostic model of patient with sepsis readiness to early mobilization with assistance.

MATERIAL AND METHODS

A single-center retrospective cohort observational study with analysis of 780 electronic medical records of patients with sepsis from the «Intensive therapy of patients with severe community-acquired pneumonia» base of the North-Western State Medical University named after I. I. Mechnikov in the period from 2013 to 2022 was carried out. Statistical analysis by binary logistic regression method and ROC-analysis were performed using Jamovi 2.3.21 and IBM SPSS Statistics 26 softwares package.

RESULTS

The study includes the data of 519 patients with sepsis. Patients are divided into 2 study groups according to the score on the Intensive Care Unit Mobility Scale (IMS): IMS 0/1 (281 patients) and IMS ≥2 (238 patients). The predictors of IMS ≥2 for patients with sepsis have been determined: score on the APACHE II assessment scale of patient’s state severity ≤20.0 (adjusted odds ratio (AOR) 6.38; 95% CI 3.01—13.5; p<0.001), score on the CCI Charlson comorbidity index ≤3.0 (AOR 3.84; 95% CI 1.72—8.58; p=0.001), score on the mNUTRIC critical state risk scale ≤5.0 (AOR 2.81; 95% CI 1.33—5.96; p=0.007), PO₂/FiO₂ index >119.0 mm Hg (AOR 104; 95% CI 29.59—365.6; p<0.001), albumin level >25.0 g/l (AOR 2.37; 95% CI 1.11—5.06; p=0.025). The prognostic model that considers 82.3% of factors determining the dispersion of IMS ≥2 probability has been developed. Area under ROC-curve amounted to 0.967±0.007 (95% CI 0.952—0.982). Sensitivity and specificity of IMS ≥2 prognostic model in patients with sepsis at 65% threshold were 92.0 and 92.6%, respectively, and accuracy — 92.3%.

CONCLUSION

The prognostic model of patient with sepsis readiness to early mobilization with assistance has been developed based on IMS ≥2 independent predictors. This model allows to use individual approach to early mobilization with assistance and identify patients who are ready to increase physical exertion without worsening clinical condition.

Keywords:

prognostic model

early rehabilitation

sepsis

physical exercises with assistance

Authors:

Ruslyakova I.A.

North-Western State Medical University named after I. I. Mechnikov

SPIN RSCI: 3417-8804
ORCID: 0000-0003-1507-833X

Shamsutdinova E.Z.

North-Western State Medical University named after I. I. Mechnikov

ORCID: 0009-0003-5800-8697

Shirokov K.I.

North-Western State Medical University named after I. I. Mechnikov

ORCID: 0009-0008-4787-596X

Ivanova N.E.

V.A. Almazov National Medical Research Center

SPIN RSCI: 1854-7827
ORCID: 0000-0003-2790-0191

Received:

28.08.2024

Accepted:

16.11.2024

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References:

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