BJECTIVE
To clarify the prevalence of hypo-vitaminosis D taking into account its severity in the non-selective patients under in vitro fertilization program and among infertile women with concomitant thyroid pathology as well as to evaluate the effectiveness of Vital D3 prescribed to restore the physiological level of vitamin D in persons with its low level and deficiency.
MATERIAL AND METHODS
In 272 infertile women aged 35 and younger as well as over 35 years old with or without thyroid pathology the presence of hypovitaminosis D was specified according to the level of 25(OH)D3 determined in blood plasma using the immunochemiluminescent method. In 118 patients with confirmed low level or deficiency of vitamin D, hypovitaminosis D was treated with Vital D3.
RESULTS
The incidence of vitamin D metabolic disorders among all patients with in vitro fertilization was 69%. Among patients with thyroid gland diseases the frequency of hypovitaminosis D was higher both in the group of 35 years and younger (82.3% versus 57.6%; p=0.043) and in the group over 35 years old (86.3% versus 68, 6%; p=0.014). Therapy with Vital D3 for 3 months ensured the achievement of physiological concentrations of vitamin D (more than 30 ng/ml) in patients with initial low level and deficiency of vitamin D, and the result of treatment did not depend on the presence of concomitant thyroid pathology.
CONCLUSION
The prevalence of hypovitaminosis D among infertile women enrolled in an in vitro fertilization program is very high but does not differ from that in the general population. The presence of thyroid pathology significantly increases the frequency of metabolic disorders of vitamin D manifested in the form of its deficiency or insufficiency, and this pattern does not depend on the age of the patients. Vital D3 provides rapid elimination of laboratory signs of hypovitaminosis D regardless of their severity, and this effect is not affected by the presence of thyroid pathology manifested in the form of hypothyroidism.
