Influence of griseofulvin on intestinal microbiota in the treatment of microsporia in rural children

Vislobokov A.V.; Khmelnitsky R.A.; Khmelnitskaya Yu.I.

doi:https://doi.org/10.17116/klinderma202524021185

Vislobokov A.V.

Orel Skin and Venereological Clinic

ORCID: 0000-0003-2484-1827

Khmelnitsky R.A.

Orel Skin and Venereological Clinic

ORCID: 0000-0002-1128-9239

Khmelnitskaya Yu.I.

Children’s Polyclinic No. 1

ORCID: 0009-0006-6375-1444

Influence of griseofulvin on intestinal microbiota in the treatment of microsporia in rural children

Authors:

Vislobokov A.V., Khmelnitsky R.A., Khmelnitskaya Yu.I.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2025;24(2): 185‑190

DOI: 10.17116/klinderma202524021185

Read: 1241 times

Contact the author

Table of contents

To cite this article:

Vislobokov AV, Khmelnitsky RA, Khmelnitskaya YuI. Influence of griseofulvin on intestinal microbiota in the treatment of microsporia in rural children. Russian Journal of Clinical Dermatology and Venereology. 2025;24(2):185‑190. (In Russ.)
https://doi.org/10.17116/klinderma202524021185

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

Использование инфографики авторами научных работ

OBJECTIVE

To evaluate the influence of duration of griseofulvin application on intestinal microbiota in children, namely rural inhabitants, with microsporia of the scalp.

MATERIAL AND METHODS

Colonic microbiota was studied by bacteriological analysis before treatment, on the 10th and 20th days of treatment with griseofulvin administered orally at a daily dose of 21—22 mg/kg in 46 patients aged from 3 to 12 years with microsporia of the scalp.

RESULTS

The therapy’s full clinical effect, including the absence of fluorescence and elimination of the causative agent in the foci, has been noted on the 31.01±2.85th day of the treatment. Bifido-dominant content of the intestinal microflora predominated before the treatment in the children’s microbiota. There has been a decrease in mean concentrations of bifidobacteria up to 10⁶ CFU/g (40.0% reduction) and lactobacteria up to 10⁵ CFU/g (28.6% reduction) (p<0.05) compared to the baseline with a preservation of the total number of escherichia and enterobacteria concentration of 1.0∙10⁶ CFU/g on the therapy by the 20th day.

CONCLUSION

A personalized approach to combined therapy with griseofulvin in microsporia, with prescription of drugs that positively affect the species composition of the intestinal microflora, is needed.

Keywords:

microsporia

children

treatment

griseofulvin

microbiota

Authors:

Vislobokov A.V.

Orel Skin and Venereological Clinic

ORCID: 0000-0003-2484-1827

Khmelnitsky R.A.

Orel Skin and Venereological Clinic

ORCID: 0000-0002-1128-9239

Khmelnitskaya Yu.I.

Children’s Polyclinic No. 1

ORCID: 0009-0006-6375-1444

Received:

11.04.2024

Accepted:

24.02.2025

Close metadata

References:

Antonova SB, Ufimtseva MA. The incidence of microsporia: epidemiological aspects, modern features of the course. Pediatrics. The Magazine named after G.N. Speransky. Clinical Medicine. 2016;95(2):142-146. (In Russ.).
Kubanov AA, Bogdanova EV. Total activities of medical organizations providing medical care in the field of dermatovenerology in 2020: work in a pandemic. Bulletin of Dermatology and Venereology. 2021;97(4):8-33. (In Russ.). https://doi.org/10.25208/vdv1261
Dermatovenerology, 2015. Klinicheskie rekomendatsii. Bolezni kozhi, infektsii, peredayushchiesya polovym putem. Edited by Kubanova AA. M.: DEX-Press; 2016. (In Russ.).
Bondarenko VM, Boev BV, Lykova EA, Vorobyov AA. Dysbiosis of the gastrointestinal tract. Russian Journal of Gastroenterology, Hepatology and Colonoproctology. 1998;1:66-77. (In Russ.).
Sergeev AYu, Sergeev YuV. Gribkovye infektsii. Rukovodstvo dlya vrachej. 2nd ed. M.: BINOM-Press; 2008. (In Russ.).
Yakovlev AB. Systemic therapy of mycoses of hairy skin areas: the possibilities of adjuvant drugs. Effective Pharmacotherapy. 2019;15(11):6-10. (In Russ.).
Blat SF, Khavkin AI. Intestinal microbiocenosis and immunity. Russian Bulletin of Perinatology and Pediatrics. 2011;1:66-72. (In Russ.).
Stark PL, Lee A. The microbial ecology of the large bowl of breast-feed and formula-fed infants during the first year of life. J Med Microbiol. May 1982; 5(2):189-203. Walker & Duffy, 1998. https://doi.org/10.1099/00222615-15-2-189
Harmsen HJM, Wldeboer-Veloo ACM, Raangs GC, Wagendorp AA, Klijn N, Bindels JG, Welling GW. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Ped Gastroenterol Nutr. Jan 2000;30:61-67. https://doi.org/10.1097/00005176-200001000-00019
Salminen S, Bouly C, Boutron-Ruault MC, Cummings JH, Franck A, Gibson GR, Isolauri E, Moreau MC, Roberfroid M, Rowland I. Functional food science and gastrointestinal physiology and function. Br J Nutrition. 1998;80(1):S147-S171. https://doi.org/10.1079/BJN19980108
Vorob’yov AA, Bondarenko VM, Lykova EA, Grigoriev AV, Matsulevich TM. Microecological disorders in clinical pathology and their correction with bifid-containing probiotics. Bulletin of the Russian Academy of Sciences. 2004;2:13-17. (In Russ.).
Shenderov BA. Meditsinskaya mikrobnaya ekologiya i funktsionalnoe pitanie. Vol. 1. M.: Grant; 1998. (In Russ.).
Volynets GV, Khavkin AI, Skvortsova TA, Nikitin AV, Matkash VV. Diseases of the liver and intestinal microbiome. Russian Pediatric Journal. 2019; 21(6):366-377. (In Russ.).
Gibson GR, Roberfroid M. Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. J Nutrition. 1995;1256:1401-1412. https://doi.org/10.1093/jn/125.6.1401
Zahra Al Bandar, Marlies Dekkers Nature, Aqua Mouse and Nagar Naderpoor. The Gut Microbiota and Inflammation: An Overview. Int J Environ. Res Public Health. 2020;17(20):7618. https://doi.org/10.3390/ijerph17207618
Sergeev AYu, Sergeev YuV. Kandidoz zheludochno-kishechnogo trakta. M. 2000:322-345. (In Russ.).
Otraslevoj standart «Protokol vedeniya bol’nykh. Disbakterioz kishechnika»/OST 91500.11.0004-2003. Order of the Ministry of Health of the Russian Federation No. 231. Dated 06/09/2003. [electronic resource]. Accessed March 11, 2024. https://www.rosminzdrav.ru
Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci USA. 2011;108:4554-4561. https://doi.org/10.1073/pnas.1000087107
Duval RE, Grare M, Demoré B. Fight against antimicrobial resistance: we always need new antibacterials but for right bacteria. Molecules. 2019; 24(17):3152. https://doi.org/10.3390/molecules24173152

Bernier A, Rumyantseva T, Reques L, Volkova N, Kyburz Y, Maximov O, Derrienic E, Guschin A, Bouscaillou J, Luhmann N, Pataut D. HIV and other sexually transmitted infections among female sex workers in Moscow (Russia): prevalence and associated risk factors. Sex Transm Infect. 2020 Dec;96(8):601-607. https://doi.org/10.1136/sextrans-2019-054299

Shipitsyna E, Khusnutdinova T, Budilovskaya O, et al. Bacterial vaginosis-associated vaginal microbiota is an age-independent risk factor for Chlamydia trachomatis, Mycoplasma genitalium and Trichomonas vaginalis infections in low-risk women, St. Petersburg, Russia. Eur J Clin Microbiol Infect Dis. 2020;39(7):1221-1230. https://doi.org/10.1007/s10096-020-03831-w