Pharmacological treatment and prevention of ischemia-reperfusion syndrome in percutaneous coronary intervention

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OBJECTIVE

To study modern strategies for pharmacological treatment and prevention of reperfusion-ischemia syndrome in percutaneous coronary intervention.

MATERIAL AND METHODS

Literature data were searched in the PubMed, Google Scholar and eLibrary databases.EN in accordance with PRISMA principles (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).

RESULTS

We found numerous strategies for treatment and prevention of reperfusion-ischemia syndrome in percutaneous coronary intervention. However, there is no a single technique ensuring absolute effectiveness. Various approaches, such as antioxidants, medications improving microcirculation and even innovative methods are actively being developed. However, their results can vary depending on characteristics of patients, degree of ischemia and other concomitant factors.

CONCLUSION

The number of clinical studies devoted to cardiac protection during percutaneous coronary intervention significantly increased in recent years. This indicates high interest of medical community in the study of reperfusion-ischemia syndrome.

Keywords:

myocardial reperfusion-ischemia syndrome

percutaneous coronary intervention

treatment

prevention

succinate-containing preparations

Authors:

Semigolovskiy N.Yu.

Sokolov North-Western District Scientific Clinical Center;
Saint Petersburg State University

ORCID: 0000-0003-4168-1853

Lobachenko I.G.

Sokolov North-Western District Scientific Clinical Center

ORCID: 0009-0007-5787-9115

Simutis I.S.

Sokolov North-Western District Scientific Clinical Center;
Mechnikov North-Western State Medical University

ORCID: 0000-0002-2537-0142

Danilov M.S.

Sokolov North-Western District Scientific Clinical Center;
Mechnikov North-Western State Medical University

ORCID: 0000-0001-5961-7433

Yusupov E.S.

Sokolov North-Western District Scientific Clinical Center

ORCID: 0000-0002-4716-0314

Ratnikov V.A.

Sokolov North-Western District Scientific Clinical Center;
Saint Petersburg State University

ORCID: 0000-0002-9645-8408

Enkina T.N.

Sokolov North-Western District Scientific Clinical Center;
Inozemtsev Academy of Medical Education

Stelyukova M.A.

Pavlov First Saint Petersburg State Medical University

ORCID: 0009-0004-3227-9031

Received:

28.01.2025

Accepted:

20.02.2025

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