THE PURPOSE OF THE STUDY
Was to study the health status of newborns born to mothers with papillomavirus infection in the early neonatal period.
MATERIAL AND METHODS
Presented the features of the course of gestation and childbirth in 51 pregnant women with papillomavirus infection, as well as the results of an examination of their 51 newborns in the early neonatal period. Standard clinical, laboratory and instrumental methods were used in this work. The human papilloma virus (HPV) DNA was detected by polymerase chain reaction in buccal scraping and aspirate from the stomach in newborns, in umbilical cord blood, in scraping from the maternal and fetal surfaces of the placenta.
RESULTS
It was found that in HPV-positive pregnant women the most frequently diagnosed were vaginal infections (cervicitis — 84.3%, bacterial vaginosis — 35.3%) and gestational complications such as threatening miscarriage (47.1%) and placental insufficiency (33.3%). The highest frequency in pregnant women included such high-oncogenic types of HPV as the 51st, 16th and 56th, as well as low-oncogenic types of the 6th and 11th, which is a risk factor for the development of oncopathology in the mother and recurrent respiratory papillomatosis in the offspring. The transmission rate of HPV from mother to newborn was 17.6%. The main pathology in newborns in the early neonatal period was various forms of intrauterine infection (35.3%) and perinatal CNS injuries (23.5%).
CONCLUSION
High incidence of cervicovaginal infections (cervicitis — 84.3%, bacterial vaginosis — 35.3%) and gestational complications (threatening miscarriage — 47.1%, placental insufficiency — 33.3%) in HPV-positive pregnant women is a risk factor of of the fetus and newborn pathology development. The transmission rate of HPV from mother to newborn was 17.6%. The most informative and research accessible locus to collect material for HPV detection in a newborn is buccal scraping. Papillomavirus infection in the mother leads to the development of intrauterine infection (35.3%) and CNS injury (23.5%) in the newborn. Thus, human papillomavirus infection complicates the gestation course, contributing to the development of threatening miscarriage and placental insufficiency, which adversely affects the fetus. Human papillomavirus infection in pregnant women is a risk factor for transmission of HPV from the mother to the newborn and leads to the manifestation of intrauterine infection and CNS injurie in the newborn.
