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Agaltsov M.V.

National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia

Tyutyunov N.N.

National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia

Novikov M.Yu.

National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia

Kiselev A.R.

National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia

Comorbidity in patients with obstructive sleep apnea. Part 2. The most clinically significant comorbid interactions

Authors:

Agaltsov M.V., Tyutyunov N.N., Novikov M.Yu., Kiselev A.R., Drapkina O.M.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2026;29(4): 96‑102

DOI: 10.17116/profmed20262904196

Read: 279 times

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Table of contents

COMORBIDITY IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA. PART 2. THE MOST CLINICALLY SIGNIFICANT COMORBID INTERACTIONS
COMORBIDITY IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA. PART 2. THE MOST CLINICALLY SIGNIFICANT COMORBID INTERACTIONS

To cite this article:

Agaltsov MV, Tyutyunov NN, Novikov MYu, Kiselev AR, Drapkina OM. Comorbidity in patients with obstructive sleep apnea. Part 2. The most clinically significant comorbid interactions. Russian Journal of Preventive Medicine. 2026;29(4):96‑102. (In Russ.)
https://doi.org/10.17116/profmed20262904196

 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The second part of literature review is devoted to in-depth analysis of clinical associations of obstructive sleep apnea (OSA) with cardiometabolic comorbid diseases.

OBJECTIVE

To systematize current concepts on individual variants of comorbid interactions in obstructive sleep apnea (OSA).

MATERIALS AND METHODS

A systematic search was conducted in Scopus, PubMed, Web of Science, Google Scholar, CyberLeninka databases for 2014—2024 period using keywords specific for OSA and particular nosologies. Relevant publications were selected by authors manually based on the analysis of heading, abstract and full text.

RESULTS

The epidemiology and mechanisms of bilateral interaction of OSA with arterial hypertension, chronic heart failure, cardiac arrhythmias, obesity and type 2 diabetes mellitus are considered in detail. The role of key pathogenetic links in each of the comorbid interactions is shown. The role of OSA as a key link in the comorbidity structure providing «vicious circles» complex persistence underlying the cardiometabolic continuum is discussed based on the obtained data. It is noted that OSA therapy impact on the long-term outcomes of comorbid diseases does not always allow to achieve the desired results.

CONCLUSION

The management of patients with obstructive sleep apnea and other comorbid diseases should be carried out using a comprehensive interdisciplinary approach.

Keywords:

obstructive sleep apnea
comorbidity
arterial hypertension
chronic heart failure
atrial fibrillation
type 2 diabetes mellitus
obesity
pathogenetic mechanisms
PAP therapy

Authors:

Agaltsov M.V.

National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia

Tyutyunov N.N.

National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia

Novikov M.Yu.

National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia

Kiselev A.R.

National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia

Received:

15.11.2025

Accepted:

16.01.2026

Close metadata

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