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Gureeva L.V.

Tver State Medical University

Rad’kov O.V.

Tver State Medical University

Premature birth and obesity: epidemiology, pathogenesis and obstetric tactics

Authors:

Gureeva L.V., Rad’kov O.V.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2025;25(2): 29‑34

DOI: 10.17116/rosakush20252502129

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Table of contents

PREMATURE BIRTH AND OBESITY: EPIDEMIOLOGY, PATHOGENESIS AND OBSTETRIC TACTICS
PREMATURE BIRTH AND OBESITY: EPIDEMIOLOGY, PATHOGENESIS AND OBSTETRIC TACTICS

To cite this article:

Gureeva LV, Rad’kov OV. Premature birth and obesity: epidemiology, pathogenesis and obstetric tactics. Russian Bulletin of Obstetrician-Gynecologist. 2025;25(2):29‑34. (In Russ.)
https://doi.org/10.17116/rosakush20252502129

 
Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The problem of premature birth (PR) in obese patients may be of particular importance in epidemiology, pathogenesis, and obstetric tactics. The review article analyzes scientific data on the effect of maternal obesity on the risk of premature and the mechanisms of spontaneous early delivery. Information on methods for predicting premature delivery, taking into account the characteristics of cervicometry data in obese patients, is presented. The safety and effectiveness of tocolytic therapy among obese pregnant women at risk of spontaneous premature delivery are highlighted.

Keywords:

premature birth
obesity
risk factors
body mass index

Authors:

Gureeva L.V.

Tver State Medical University

Rad’kov O.V.

Tver State Medical University

Received:

05.04.2024

Accepted:

20.05.2024

Close metadata

References:

  1. Premature birth. Clinical guidelines. 2020. (In Russ.). cr.minzdrav.gov.ru/recomend/331
  2. Ciapponi A, Bardach A, Comandé D, Berrueta M, Argento FJ, Rodriguez Cairoli F, Zamora N, Santa María V, Xiong X, Zaraa S, Mazzoni A, Buekens P. COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes. PLoS One.2021;16:6:e0253974. https://doi.org/10.1371/journal.pone.0253974
  3. Radzinskii VE, Kostin IN, Olenev AS, Gagaev ChG, Parygina AN, Gavrilova AA, Gagaev DCh, Damirova KF, Kuznetsova OA, Smirnova TV. Preterm delivery is an unsettled world problem. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie. 2018;6:3:Supplement:55-64. (In Russ.). https://doi.org/10.24411/2303-9698-2018-13909
  4. FIGO Working Group on Good Clinical Practice in Maternal-Fetal Medicine. Good clinical practice advice: Prediction of preterm labor and preterm premature rupture of membranes. Int J Gynaecol Obstet. 2019;144:3:340-346.  https://doi.org/10.1002/ijgo.12744
  5. Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet M, Lumbiganon P. The global epidemiology of preterm birth. Best Pract Res Clin Obstet Gynaecol. 2018;52:3-12.  doi.org//10.1016/j.bpobgyn.2018.04.003
  6. Liu B, Xu G, Sun Y, Du Y, Gao R, Snetselaar LG, Santillan MK, Bao W. Association between maternal pre-pregnancy obesity and preterm birth according to maternal age and race or ethnicity: a population-based study. Lancet Diabetes Endocrinol. 2019;7:9:707-714.  https://doi.org/10.1016/S2213-8587(19)30193-7
  7. Li L, Chen Y, Lin Z, Lin W, Liu Y, Ou W, Zeng C, Ke L. Association of pre-pregnancy body mass index with adverse pregnancy outcome among first-time mothers. Peer J. 2020;8:e10123. https://doi.org/10.7717/peerj.10123
  8. Crump C, Sundquist J, Sundquist K. Preterm delivery and long-term mortality in women: national cohort and co-sibling study. BMJ. 2020;370:m2533. https://doi.org/10.1136/bmj.m2533
  9. da Fonseca EB, Damião R, Moreira DA. Preterm birth prevention. Best Pract Res Clin Obstet Gynaecol. 2020;69:40-49.  https://doi.org/10.1016/j.bpobgyn.2020.09.003
  10. Glover AV, Manuck TA. Screening for spontaneous preterm birth and resultant therapies to reduce neonatal morbidity and mortality: A review. Semin Fetal Neonatal Med. 2018;23:2:126-132.  https://doi.org/10.1016/j.siny.2017.11.007
  11. Granese R, Gitto E, D’Angelo G, Falsaperla R, Corsello G, Amadore D, Calagna G, Fazzolari I, Grasso R, Triolo O. Preterm birth: seven-year retrospective study in a single centre population. Ital J Pediatr. 2019;45:1:45.  https://doi.org/10.1186/s13052-019-0643-9
  12. Smirnova AV, Borzova NYu, Malyshkina AI, Talanova IE. Prospects for predicting preterm labor. Russian Bulletin of Obstetrician-Gynecologist. 2023;23:6-2:127-134. (In Russ.). https://doi.org/10.17116/rosakush202323062127
  13. Mehta-Lee SS, Palma A, Bernstein PS, Lounsbury D, Schlecht NF. A Preconception nomogram to predict preterm delivery. Matern Child Health J. 2017;21:1:118-127.  https://doi.org/10.1007/s10995-016-2100-3
  14. Timoshina IV, Komissarova LM, Timofeeva LA, Il’yasova NA, Burlev VA, Khodzhaeva ZS. Clinical features of pregnancy course and outcomes in women with obesity and excessive weight gain during pregnancy. Akusherstvo i ginekologiya. 2015;12:57-63. (In Russ.).
  15. Cnattingius S, Villamor E, Johansson S, Edstedt Bonamy AK, Persson M, Wikström AK, Granath F. Maternal obesity and risk of preterm delivery. JAMA. 2013;309:22:2362-2370. https://doi.org/10.1001/jama.2013.6295
  16. Kapustin RV, Alekseenkova EN, Arzhanova ON, Petyaeva AV, Ataeva MG, Yusenko SR. Preterm birth in women with diabetes mellitus. Zhurnal akusherstva i zhenskikh boleznei. 2020;69:1:17-26. (In Russ.). https://doi.org/10.17816/JOWD69117-26
  17. Seregina DS, Nikolaenkov IP, Kuz’minykh TU. Obesity represents a strong pathogenetic link with the pathology of pregnancy and childbirth. Zhurnal akusherstva i zhenskikh boleznei. 2020;69:2:73-82. (In Russ.). https://doi.org/10.17816/JOWD69273-82
  18. Venkatesh KK, Cantonwine DE, Zera C, Arjona M, Smith NA, Robinson JN, McElrath TF. Is there an association between body mass index and cervical length? Implications for obesity and cervical length management in pregnancy. Am J Perinatol. 2017;34:6:568-575.  https://doi.org/10.1055/s-0036-1594242
  19. Hadley EE, Discacciati A, Costantine MM, Munn MB, Pacheco LD, Saade GR, Chiossi G. Maternal obesity is associated with chorioamnionitis and earlier indicated preterm delivery among expectantly managed women with preterm premature rupture of membranes. J Matern Fetal Neonatal Med. 2019;32:2:271-278.  https://doi.org/10.1080/14767058.2017.1378329
  20. Tersigni C, Neri C, D’Ippolito S, Garofalo S, Martino C, Lanzone A, Scambia G, Di Simone N. Impact of maternal obesity on the risk of preterm delivery: insights into pathogenic mechanisms. J Matern Fetal Neonatal Med. 2020;1-6.  https://doi.org/10.1080/14767058.2020.1817370
  21. Hajagos-Tóth J, Ducza E, Samavati R, Vari SG, Gaspar R. Obesity in pregnancy: a novel concept on the roles of adipokines in uterine contractility. Croat Med J. 2017;58:2:96-104.  https://doi.org/10.3325/cmj.2017.58.96
  22. Shaw GM, Wise PH, Mayo J, Carmichael SL, Ley C, Lyell DJ, Shachar BZ, Melsop K, Phibbs CS, Stevenson DK, Parsonnet J, Gould JB. Maternal prepregnancy body mass index and risk of spontaneous preterm birth. Paediatr Perinat Epidemiol. 2014;28:4:302-311.  https://doi.org/10.1111/ppe.12125
  23. Palacio M, Caradeux J, Sánchez M, Cobo T, Figueras F, Coll O, Gratacós E, Cararach V. Uterine cervical length measurement to reduce length of stay in patients admitted for threatened preterm labor: a randomized trial. Fetal Diagn Ther. 2018;43:3:184-190.  https://doi.org/10.1159/000477930
  24. Vinturache A, McKeating A, Daly N, Sheehan S, Turner M. Maternal body mass index and the prevalence of spontaneous and elective preterm deliveries in an Irish obstetric population: a retrospective cohort study. BMJ Open. 2017;7:10:e015258. https://doi.org/10.1136/bmjopen-2016-015258
  25. Pigatti Silva F, Souza RT, Cecatti JG, Passini R Jr, Tedesco RP, Lajos GJ, Nomura ML, Rehder PM, Dias TZ, Oliveira PF, Silva CM. Role of body mass index and gestational weight gain on preterm birth and adverse perinatal outcomes. Sci Rep. 2019;9:1:13093. https://doi.org/10.1038/s41598-019-49704-x
  26. Masho SW, Bishop DL, Munn M. Pre-pregnancy BMI and weight gain: where is the tipping point for preterm birth? BMC Pregnancy Childbirth. 2013;13:120.  https://doi.org/10.1186/1471-2393-13-120
  27. Goldstein RF, Abell SK, Ranasinha S, Misso M, Boyle JA, Black MH, Li N, Hu G, Corrado F, Rode L, Kim YJ, Haugen M, Song WO, Kim MH, Bogaerts A, Devlieger R, Chung JH, Teede HJ. Association of gestational weight gain with maternal and infant outcomes: a systematic review and meta-analysis. JAMA. 2017;317:21:2207-2225. https://doi.org/10.1001/jama.2017.3635
  28. Batyreva NV, Sinitsyna SS, Kravchenko EN, Kuklina LV, Boiko IA. Risk factors for very preterm delivery. Mat’ i ditya v Kuzbasse. 2018;1:72:57-61. (In Russ.).
  29. Palatnik A, Miller ES, Son M, Kominiarek MA. Association among maternal obesity, cervical length, and preterm birth. Am J Perinatol. 2017;34:5:471-479.  https://doi.org/10.1055/s-0036-1593350
  30. Slack E, Best KE, Rankin J, Heslehurst N. Maternal obesity classes, preterm and post-term birth: a retrospective analysis of 479,864 births in England. BMC Pregnancy Childbirth. 2019;19:1:434.  https://doi.org/10.1186/s12884-019-2585-z
  31. Gondarenko AS, Galina TV, Smirnova TV, Kuznetsova OA, Markaryan NM, Obukang A. Scale for assessing risk of extremely preterm birth. Doktor.Ru. 2016;7:124:53-56. (In Russ.).
  32. Shklyaev AE, Semenova MV, Lyalina AS, Maksimov IE. Assessment of risk factors of premature birth. Vestnik Avitsenny. 2019;21:1:26-32. (In Russ.). https://doi.org/10.25005/2074-0581-2019-21-1-26-32
  33. Khodzhaeva ZS, Fedotovskaya OI, Donnikov AE. Clinical and anamnestic characteristics of women with idiopathic preterm labor in case of a slavic population. Akusherstvo i ginekologiya. 2014;3:28-32. (In Russ.).
  34. Dyadichkina OV, Radetskaya LE. Risk assessment scale of spontaneous preterm birth. Meditsinskie novosti. 2016;2:72-75. (In Russ.).
  35. Nazarova AO, Malyshkina AI, Nazarov SB. Risk factors for spontaneous preterm birth: results of a clinical-epidemiological study. Akusherstvo y ginekologiya. 2019;9:82-86. (In Russ.). https://doi.org/10.18565/aig.2019.9.82-86
  36. Hendler I, Goldenberg RL, Mercer BM, Iams JD, Meis PJ, Moawad AH, MacPherson CA, Caritis SN, Miodovnik M, Menard KM, Thurnau GR, Sorokin Y. The Preterm Prediction Study: association between maternal body mass index and spontaneous and indicated preterm birth. Am J Obstet Gynecol. 2005;192: 3:882-886.  https://doi.org/10.1016/j.ajog.2004.09.021
  37. Averett SL, Fletcher EK. Prepregnancy obesity and birth outcomes. Matern Child Health J. 2016;20:3:655-664.  https://doi.org/10.1007/s10995-015-1865-0
  38. Gürsoy Erzincan S, Sayin NC, Korkmaz S, Sutcu H, Inan C, Uzun Cilingir I, Varol FG. Can myometrial thickness/cervical length ratio predict preterm delivery in singleton pregnancies with threatened preterm labor? A prospective study. Arch Gynecol Obstet. 2019;299:5:1275-1282. https://doi.org/10.1007/s00404-019-05109-9
  39. Tsur A, Mayo JA, Wong RJ, Shaw GM, Stevenson DK, Gould JB. «The obesity paradox»: a reconsideration of obesity and the risk of preterm birth. J Perinatol. 2017;37:10:1088-1092. https://doi.org/10.1038/jp.2017.104
  40. Romero R, Miranda J, Chaiworapongsa T, Korzeniewski SJ, Chaemsaithong P, Gotsch F, Dong Z, Ahmed AI, Yoon BH, Hassan SS, Kim CJ, Yeo L. Prevalence and clinical significance of sterile intraamniotic inflammation in patients with preterm labor and intact membranes. Am J Reprod Immunol. 2014;72:5:458-474.  https://doi.org/10.1111/aji.12296
  41. Plazyo O, Romero R, Unkel R, Balancio A, Mial TN, Xu Y, Dong Z, Hassan SS, Gomez-Lopez N. HMGB1 induces an inflammatory response in the chorioamniotic membranes that is partially mediated by the inflammasome. Biol Reprod. 2016;95:6:130.  https://doi.org/10.1095/biolreprod.116.144139
  42. Melchor I, Burgos J, Del Campo A, Aiartzaguena A, Gutiérrez J, Melchor JC. Effect of maternal obesity on pregnancy outcomes in women delivering singleton babies: a historical cohort study. J Perinat Med. 2019;47:6:625-630.  https://doi.org/10.1515/jpm-2019-0103
  43. Smith CJ, Baer RJ, Oltman SP, Breheny PJ, Bao W, Robinson JG, Dagle JM, Liang L, Feuer SK, Chambers CD, Jelliffe-Pawlowski LL, Ryckman KK. Maternal dyslipidemia and risk for preterm birth. PLoS One. 2018;13:12:e0209579. https://doi.org/10.1371/journal.pone.0209579
  44. Gureeva LV, Chistyakova OM, Paramonova EK, Rad’kov OV. Influence of tocolytic therapy with hexoprenaline on heart rate variability, lipid spectrum and glycemic level in obese pregnant women. Acta Biomedica Scientifica. 2021;6:1:7-12. (In Russ.). https://doi.org/10.29413/ABS.2021-6.1.1
  45. Nascimento IBD, Dienstmann G, de Souza MLR, Silva TRE, Fleig R, Silva JC. Dyslipidemia and maternal obesity: Prematurity and neonatal prognosis. Rev Assoc Med Bras (1992). 2018;64:3:264-271.  https://doi.org/10.1590/1806-9282.64.03.264
  46. McAuliffe FM, Killeen SL, Jacob CM, Hanson MA, Hadar E, McIntyre HD, Kapur A, Kihara AB, Ma RC, Divakar H, Hod M. Management of prepregnancy, pregnancy, and postpartum obesity from the FIGO Pregnancy and Non-Communicable Diseases Committee: A FIGO (International Federation of Gynecology and Obstetrics) guideline. Int J Gynaecol Obstet. 2020;151:Suppl 1:16-36.  https://doi.org/10.1002/ijgo.13334
  47. Venkatesh KK, Manuck TA. Maternal body mass index and cervical length among women with a history of spontaneous preterm birth. J Matern Fetal Neonatal Med. 2020;33:5:825-830.  https://doi.org/10.1080/14767058.2018.1505856
  48. Karyakina IV, Astaf’eva OV, Mikheeva NV. Relationship of the mass index of the body and the cervical length in II trimester pregnancy for prediction preterm birth. Meditsinskaya visualizatsiya. 2019;23:1:97-105. (In Russ.). https://doi.org/10.24835/1607-0763-2019-1-97-105
  49. Gureeva LV, Chistyakova OM, Grebenshchikova LYu, Rad’kov OV. The value of ultrasound cervicometry for predicting premature birth in pregnant women with normal body weight and obesity. Rossiiskii vestnik akushera-ginekologa. 2021;21:5:90-95. (In Russ.). https://doi.org/10.17116/rosakush20212105190
  50. Gureeva LV, Chistyakova OM, Grebenshchikova LYu, Kolbasnikov SV, Rad’kov OV. Efficiency and safety of tocolytic therapy with hexoprenaline depending on body mass index in pregnant women. Rossiiskii vestnik akushera-ginekologa. 2021;21:4:75-80. (In Russ.). https://doi.org/10.17116/rosakush20212104175
  51. Shigemi D, Aso Sh, Yasunaga H. Inappropriate use of ritodrine hydrochloride for threatened preterm birth in Japan: a retrospective cohort study using a national inpatient database. BMC Pregnancy Childbirth. 2019;19:1:204.  https://doi.org/10.1186/s12884-019-2352-1
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