The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Ekusheva E.V.

Academy of Postgraduate Education of the Federal Medical Biological Agency of Russia

Zotkin E.G.

V.A. Nasonova Research Institute of Rheumatology

Dydykina I.S.

V.A. Nasonova Research Institute of Rheumatology

Dukhanin A.S.

N.I. Pirogov Russian National Research Medical University (Pirogov University)

Kalyuzhin O.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Ar’kov V.V.

S.I. Spasokukotsky Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine

Sidenkov A.Yu.

OOO «SSMC» 2024

Akarachkova E.S.

Almatek, OOO

Review and resolution of the Council of Experts on the topic «The role of the combination of undenatured type II collagen UC-II, vitamin C, and trace elements in recovering and maintaining the function of the musculoskeletal system, and preservation of health of the joints»

Authors:

Ekusheva E.V., Zotkin E.G., Dydykina I.S., Dukhanin A.S., Kalyuzhin O.V., Ar’kov V.V., Sidenkov A.Yu., Akarachkova E.S.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(4): 102‑110

DOI: 10.17116/profmed202528041102

Read: 3666 times

Download PDF (RU)
Contact the author
Table of contents

REVIEW AND RESOLUTION OF THE COUNCIL OF EXPERTS ON THE TOPIC «THE ROLE OF THE COMBINATION OF UNDENATURED TYPE II COLLAGEN UC-II, VITAMIN C, AND TRACE ELEMENTS IN RECOVERING AND MAINTAINING THE FUNCTION OF THE MUSCULOSKELETAL SYSTEM, AND PRESERVATION OF HEALTH OF THE JOINTS»
REVIEW AND RESOLUTION OF THE COUNCIL OF EXPERTS ON THE TOPIC «THE ROLE OF THE COMBINATION OF UNDENATURED TYPE II COLLAGEN UC-II, VITAMIN C, AND TRACE ELEMENTS IN RECOVERING AND MAINTAINING THE FUNCTION OF THE MUSCULOSKELETAL SYSTEM, AND PRESERVATION OF HEALTH OF THE JOINTS»

To cite this article:

Ekusheva EV, Zotkin EG, Dydykina IS, et al. . Review and resolution of the Council of Experts on the topic «The role of the combination of undenatured type II collagen UC-II, vitamin C, and trace elements in recovering and maintaining the function of the musculoskeletal system, and preservation of health of the joints». Russian Journal of Preventive Medicine. 2025;28(4):102‑110. (In Russ.)
https://doi.org/10.17116/profmed202528041102

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Features of como­rbidity pathology in young people. Russian Journal of Preventive Medi­cine. 2024;(11):63-69
Proton pump inhi­bitors: posi­tive and nega­tive properties. On the 45th anni­versary of their discovery. Russian Journal of Preventive Medi­cine. 2024;(11):135-140
Study of opinions of medi­cal students on medi­cal prevention issues. Russian Journal of Preventive Medi­cine. 2024;(12):69-74
Asse­ssment of risk of deve­loping fractures and sarcopenia and quality of life of patients with chro­nic kidney disease at the outpatient stage. Russian Journal of Preventive Medi­cine. 2024;(12):88-91
Gastric cancer: inci­dence, risk factors, screening. Russian Journal of Preventive Medi­cine. 2024;(12):135-139
The rela­tionship of diet and nutrition with the frequency of migraine atta­cks. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):30-35
Chondroprotective therapy and adju­vant support for patients with chro­nic lower back pain. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):120-125
A portrait of a doctor with Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):160-164
Prevention of periodontal inflammation in microgravity mode­ling. Stomatology. 2024;(6-2):23-28
Effe­ctiveness of risk-guided cardiac mana­gement in patients with HER2-positive breast cancer and cancer therapy-related cardiac dysfunction. Russian Cardiology Bulletin. 2024;(4-2):144-153
Abstract:

On October 6, 2024, the Council of Experts held a meeting to discuss «The role of the combination of undenatured type II collagen UC-II, vitamin C, and trace elements in recovering and maintaining the function of the musculoskeletal system and preservation of joint health.» New opportunities in preventing and treating osteoarthritis (OA), including in comorbid patients, are considered. Leading experts in rheumatology, clinical pharmacology, neurology, clinical immunology, orthopedics, traumatology, and sports medicine attended the meeting. The OA phenotypes, the mechanism of action of undenatured type II collagen, the data of clinical studies with undenatured collagen UC II, the integrative, interdisciplinary approach in the prevention and treatment of OA, and the prospects for using the VoltaFlex dietary supplement were analyzed. The resolution of the Council of Experts emphasized the importance of an integrated approach to the treatment of OA, including pharmacological and non-drug methods, and recommended using a combination of undenatured type II UC-II collagen, vitamin C, and trace elements to recover and maintain the musculoskeletal system’s function and preserve joint health.

Keywords:

undenatured collagen
UC-II
oral tolerance
flexokinetic
osteoarthritis
diclofenac diethylamine (DDEA)
Emulgel
comorbidity
prevention
integrative therapy
VoltaFlex

Authors:

Ekusheva E.V.

Academy of Postgraduate Education of the Federal Medical Biological Agency of Russia

Zotkin E.G.

V.A. Nasonova Research Institute of Rheumatology

Dydykina I.S.

V.A. Nasonova Research Institute of Rheumatology

Dukhanin A.S.

N.I. Pirogov Russian National Research Medical University (Pirogov University)

Kalyuzhin O.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Ar’kov V.V.

S.I. Spasokukotsky Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine

Sidenkov A.Yu.

OOO «SSMC» 2024

Akarachkova E.S.

Almatek, OOO

Received:

18.02.2025

Accepted:

20.03.2025

Close metadata

References:

  1. Global Burden of Disease Collaborative Network. Global Burden of Disease Study 2019 (GBD 2019) Results. 2020. Accessed December 25, 2024. https://ghdx.healthdata.org/gbdresults-tool
  2. Samoday VG, Varfolomeev DI, Kuznetsova VP, et al. Comprehensive conservative treatment as a possible alternative to surgery in difficult orthopedic situations. Klinitsist. 2022;16(2):58-53. (In Russ.). https://doi.org/10.17650/1818-8338-2022-16-2-K662
  3. Mazurov VI, Alekseeva LI, Belyaeva IB, et al. Efficacy, safety and prospects of using a combination of native type II collagen, methylsulfonylmethane, boswellic acids, vitamin C and vitamin D3 in knee osteoarthritis: a resolution of the Expert panel. Terapevticheskii Arkhiv. 2024;96(1):68-74. (In Russ.).
  4. Swain S, Sarmanova A, Coupland C, et al. Comorbidities in Osteoarthritis: A Systematic Review and Meta-Analysis of Observational Studies. Arthritis care & research. 2020;72(7):991-1000. https://doi.org/10.1002/acr.24008
  5. Lila AM, Alekseeva LI, Telyshev KA. Current approaches to osteoarthritis phenotyping. Sovremennaya revmatologiya. 2019;13(2):4-8. (In Russ.). https://doi.org/10.14412/1996-7012-2019-2-4-8
  6. Veronese N, Cooper C, Bruyère O, et al. Multimodal Multidisciplinary Management of Patients with Moderate to Severe Pain in Knee Osteoarthritis: A Need to Meet Patient Expectations. Drugs. 2022;82(13):1347-1355. https://doi.org/10.1007/s40265-022-01773-5
  7. Clifford T, Ventress M, Allerton DM, et al. The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial. Amino Acids. 2019;51(4):691-704.  https://doi.org/10.1007/s00726-019-02706-5
  8. Garcia-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, et al. Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials. International Orthopaedics. 2019;49(3):531-538.  https://doi.org/10.1007/s00264-018-4211-5
  9. Van Vijven JP, Luijsterburg PA, Verhagen AP, et al. Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review. Osteoarthritis Cartilage. 2012;20(8):809-821.  https://doi.org/10.1016/j.joca.2012.04.008
  10. Dydykina IS, Kovalenko PS, Kovalenko AA, et al. The value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the joints. Meditsinskiy sovet. 2022;16(14):145-153. (In Russ.). https://doi.org/10.21518/2079-701X-2022-16-14-145-153
  11. Klatt AR, Paul-Klausch B, Klinger G, et al. A critical role for collagen II in cartilage matrix degradation: collagen II induces pro-inflammatory cytokines and MMPs in primary human chondrocytes. Journal of Orthopaedic Research. 2009;27(1):65-70.  https://doi.org/10.1002/jor.20716
  12. Gromova OA, Torshin IYu, Lila AM. Molecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical Evidence. Sovremennaya revmatologiya. 2022;16(5):108-113. (In Russ.). https://doi.org/10.14412/1996-7012-2022-5-108-113
  13. Martínez-Puig D, Costa-Larrión E, Rubio-Rodríguez N, et al. Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge. Nutrients. 2023;15(6):1332. https://doi.org/10.3390/nu15061332
  14. Shavlovskaya OA, Bokova IA, Romanov ID, et al. Efficacy of undenatured and hydrolyzed type II collagen in the treatment of pain syndrome. RMZh. Medicinskoe obozrenie. 2022;6(10):571-575. (In Russ.). https://doi.org/10.32364/2587-6821-2022-6-10-571-575
  15. Kramer RM, Shende VR, Motl Ny, et al. Toward a molecular understanding of protein solubility: increased negative surface charge correlates with increased solubility. Biophysical Journal. 2012;102(8):1907-1915. https://doi.org/10.1016/j.bpj.2012.01.060
  16. Harris RB, Fonseca FLA, Sharp MH, et al. Functional characterization of undenatured type II collagen supplements: Are they interchangeable? Journal of Dietary Supplements. 2022;19(6):717-732.  https://doi.org/10.1080/19390211.2021.1931621
  17. Sadigursky D, Magnavita VFS, Sá CKC, et al. Undenatured Collagen Type II For The Treatment Of Osteoarthritis Of The Knee. Acta Ortopedica Brasileira. 2022;30(2):e240572. https://doi.org/10.1590/1413-785220223002240572
  18. Crowley DC, Lau FC, Sharma P, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. International Journal of Medical Sciences. 2009;6(6):312-321.  https://doi.org/10.7150/ijms.6.312
  19. Lugo JP, Saiyed ZM, Lau FC, et al. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. Journal of the International Society of Sports Nutrition. 2013;10(1):48.  https://doi.org/10.1186/1550-2783-10-48
  20. Schön C, Knaub K, Alt W, et al. UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study. Journal of Integrative and Complementary Medicine. 2022;28(6):540-548.  https://doi.org/10.1089/jicm.2021.0365
  21. Shiojima Y, Takahashi M, Takahashi R, et al. Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study. Journal of the American Nutrition Association. 2023;42(3):224-241.  https://doi.org/10.1080/07315724.2021.2024466
  22. Pan P, Wang Y, Nyirenda MH, et al. Undenatured type II collagen protects against collagen-induced arthritis by restoring gut-joint homeostasis and immunity. Communications Biology. 2024;7(1):804.  https://doi.org/10.1038/s42003-024-06476-z
  23. Orhan C, Sahin E, Er B, et al. Effects of Exercise Combined with Undenatured Type II Collagen on Endurance Capacity, Antioxidant Status, Muscle Lipogenic Genes and E3 Ubiquitin Ligases in Rats. Animals (Basel). 2021; 11(3):851.  https://doi.org/10.3390/ani11030851
  24. Lila AM, Alekseeva LI, Taskina EA, et al. Osteoarthritis as an interdisciplinary problem: treatment algorithm for physicians and general practitioners. Sovremennaya revmatologiya. 2021;15(5):68-75. (In Russ.). https://doi.org/10.14412/1996-7012-2021-5-68-75
  25. Yakusheva EV, Dukhanin AS, Iskra DA, et al. Personalized patient-oriented approach to the treatment of musculoskeletal pain syndrome using over-the-counter medications. Resolution of the Expert Council (May 28, 2023). S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(8):134-138. (In Russ.). https://doi.org/10.17116/jnevro2023123081134
  26. Dydykina IS, Nurbaieva KS, Kovalenko PS, et al. From knowing the mechanism of action to choosing a method for the prevention and treatment of osteoarthritis. RMJ. 2020;7:14-18. (In Russ.). https://www.rmj.ru/articles/revmatologiya/Ot_znaniya_mehanizma_deystviya__k_prinyatiyu_resheniya_o_vybore_podhoda_k_profilaktike_i_lecheniyu_osteoartrita/#ixzz8wqAcGwpj
  27. Palacios C. The role of nutrients in bone health, from A to Z. Critical Reviews in Food Science and Nutrition. 2006;46(8):621-628.  https://doi.org/10.1080/10408390500466174
  28. Shavlovskaya OA, Gromova OA, Kochish YuA, et al. Disease-modifying osteoarthritis drugs (DMOADs): new trends in osteoarthritis therapy. Farmakojekonomika. Sovremennaja farmakojekonomika i farmakojepidemiologija. 2023;16(3):482-499 (in Russ.). https://doi.org/10.17749/2070-4909/farmakoekonomika.2023.207
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.