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Prokonich D.A.

Siberian State Medical University, Tomsk, Russia

Saprina T.V.

Siberian State Medical University, Tomsk, Russia

Voronkova O.V.

Siberian State Medical University, Tomsk, Russia

Chernyshov N.A.

Siberian State Medical University, Tomsk, Russia

Bukreeva E.B.

Siberian State Medical University, Tomsk, Russia

Characteristics of systemic inflammation parameters in patients with chronic obstructive pulmonary disease depending on the body composition

Authors:

Prokonich D.A., Saprina T.V., Voronkova O.V., Chernyshov N.A., Bukreeva E.B.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2026;29(4): 67‑75

DOI: 10.17116/profmed20262904167

Read: 449 times

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Table of contents

CHARACTERISTICS OF SYSTEMIC INFLAMMATION PARAMETERS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE DEPENDING ON THE BODY COMPOSITION
CHARACTERISTICS OF SYSTEMIC INFLAMMATION PARAMETERS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE DEPENDING ON THE BODY COMPOSITION

To cite this article:

Prokonich DA, Saprina TV, Voronkova OV, Chernyshov NA, Bukreeva EB. Characteristics of systemic inflammation parameters in patients with chronic obstructive pulmonary disease depending on the body composition. Russian Journal of Preventive Medicine. 2026;29(4):67‑75. (In Russ.)
https://doi.org/10.17116/profmed20262904167

 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

As far as the incidence of chronic respiratory diseases is increasing significantly worldwide, assessing the mutual influence of body composition on chronic obstructive pulmonary disease (COPD) and conversely is an urgent issue.

OBJECTIVE

To identify and compare cytokine and adipokine profiles in patients with chronic obstructive pulmonary disease depending on the body composition.

MATERIALS AND METHODS

This study is multicenter, comparative and case-control. Patients with COPD and conditionally healthy individuals for the control group are included. All participants of the study underwent survey, blood sampling was done to determine the levels of leptin, resistin, adiponectin, visfatin, tumor necrosis factor-alpha (TNF-α), IL-4, IL-6, IL-8, IL-10 interleukins, monocyte chemoattractant protein-1 (MCP-1). Complete blood count was performed for calculation of the inflammation indices: systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR); lymphocyte-to-monocyte ratio (LMR), platelet-neutrophil product (PPN). Anthropometry, bioimpedance analysis and spirometry were also carried out.

RESULTS

The highest levels of inflammation indices were determined for patients with COPD and normal body mass. When patients were divided by the body fat percentage, those with the lowest amount of fat had the highest levels of TNF-α and MCP-1 inflammatory cytokines and at the same time the highest values of anti-inflammatory IL-10 and adiponektin that is probably a protective mechanism at the higher level of inflammation. Patients with COPD and higher fat-free mass index (17 kg/m2 and above) had better spirometry and higher MCP-1 indicators.

CONCLUSION

The body composition and mainly the adipose tissue have a relationship with adipocytokines and inflammation indices in patients with chronic obstructive pulmonary disease. Bioimpedance analysis can be a valuable diagnostic tool for developing personalized recommendations on correction of the nutritional status of patients with this pathology.

Keywords:

body composition
chronic obstructive pulmonary disease
COPD
bioimpedance analysis
adipokines
cytokines

Authors:

Prokonich D.A.

Siberian State Medical University, Tomsk, Russia

Saprina T.V.

Siberian State Medical University, Tomsk, Russia

Voronkova O.V.

Siberian State Medical University, Tomsk, Russia

Chernyshov N.A.

Siberian State Medical University, Tomsk, Russia

Bukreeva E.B.

Siberian State Medical University, Tomsk, Russia

Received:

22.10.2025

Accepted:

16.01.2026

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