Association of adipokines and sleep disorders among the 25—44 year-old people

Gafarov V.V.; Gromova E.A.; Kashtanova E.V.; Tripelgorn A.N.; Polonskaya Ya.V.; Sukhanov A.V.; Gagulin I.V.; Gafarova A.V.; Ragino Yu.I.

doi:https://doi.org/10.17116/profmed20252808141

Gafarov V.V.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases

ORCID: 0000-0001-5701-7856

Gromova E.A.

ORCID: 0000-0001-8313-3893

Kashtanova E.V.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

ORCID: 0000-0003-2268-4186

Tripelgorn A.N.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences

ORCID: 0000-0002-3898-3247

Polonskaya Ya.V.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

ORCID: 0000-0002-3538-0280

Sukhanov A.V.

Research Institute of Therapy and Preventive Medicine — branch of the Federal Research Center «Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences

ORCID: 0000-0003-1407-269X

Gagulin I.V.

ORCID: 0000-0001-5255-5647

Gafarova A.V.

ORCID: 0000-0001-5380-9434

Ragino Yu.I.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

ORCID: 0000-0002-4936-8362

Association of adipokines and sleep disorders among the 25—44 year-old people

Authors:

Gafarov V.V., Gromova E.A., Kashtanova E.V., Tripelgorn A.N., Polonskaya Ya.V., Sukhanov A.V., Gagulin I.V., Gafarova A.V., Ragino Yu.I.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(8): 41‑47

DOI: 10.17116/profmed20252808141

Read: 319 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Gafarov VV, Gromova EA, Kashtanova EV, et al. . Association of adipokines and sleep disorders among the 25—44 year-old people. Russian Journal of Preventive Medicine. 2025;28(8):41‑47. (In Russ.)
https://doi.org/10.17116/profmed20252808141

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)

Использование инфографики авторами научных работ

Close metadata

OBJECTIVE

To analyze the associations of adipokine levels (leptin, adiponectin) and sleep disorders as independent risk factors for cardiovascular diseases in residents of Novosibirsk aged 25—44 years.

MATERIALS AND METHODS

A random representative sample of individuals aged 25—44 years (975 subjects of both sexes, the response rate was 71%) in Novosibirsk was assessed (using standard methods of the WHO MONICA-psychosocial program). Sleep disorders were assessed using the sleep disorders scale included in the WHO MONICA-psychosocial protocol in 2013—2016 at the Institute of Internal and Preventive Medicine, a branch of the federal research center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences; biochemical tests to measure the level of adipokines were performed in the laboratory of clinical biochemical and hormonal studies of therapeutic diseases.

RESULTS

Sleep disorders were detected in 12% of respondents of both sexes, and in women, they were twice as common as in men. The median blood leptin level and leptin/adiponectin index were higher in individuals with sleep disorders, and the lowest in respondents without sleep disorders. The median adiponectin level was higher in individuals without sleep disorders and lower in individuals with sleep disorders. There was an increase in the rate of sleep disorders with an increase in the leptin level, and vice versa.

CONCLUSION

Sleep disorders were detected in 12% of respondents aged 25—44, and in women, they were twice as common as in men. Subjects with sleep disorders had higher blood leptin levels, a higher leptin/adiponectin index, and lower adiponectin levels compared to subjects without sleep disorders.

Keywords:

sleep disorders

leptin

adiponectin

leptin/adiponectin index

adipokines

Authors:

Gafarov V.V.

ORCID: 0000-0001-5701-7856

Gromova E.A.

ORCID: 0000-0001-8313-3893

Kashtanova E.V.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

ORCID: 0000-0003-2268-4186

Tripelgorn A.N.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences

ORCID: 0000-0002-3898-3247

Polonskaya Ya.V.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

ORCID: 0000-0002-3538-0280

Sukhanov A.V.

Research Institute of Therapy and Preventive Medicine — branch of the Federal Research Center «Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences

ORCID: 0000-0003-1407-269X

Gagulin I.V.

ORCID: 0000-0001-5255-5647

Gafarova A.V.

ORCID: 0000-0001-5380-9434

Ragino Yu.I.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

ORCID: 0000-0002-4936-8362

Received:

12.07.2024

Accepted:

24.03.2025

Close metadata

References:

Dadaeva VA, Aleksandrov AA, Orlova AS, et al. Sleep and obesity: mechanisms of relationship. Racional’naja farmakoterapija v kardiologii. 2020;16(4):564-570. (In Russ.). https://doi.org/10.20996/1819-6446-2020-08-10
Gafarov VV, Gromova EA, Panov DO, et al. Dynamics of sleep duration (2003—2018) and the risk of myocardial infarction in an open population 45—64 years in Russia/Siberia. Rossijskij kardiologicheskij zhurnal. 2022; 27(5):4943. (In Russ.). https://doi.org/10.15829/1560-4071-2022-4943
Grandner MA. Sleep, Health, and Society. Sleep Medicine Clinics. 2017;12:1-22. https://doi.org/10.1016/j.jsmc.2016.10.012
Wei Z, Chen Y, Upender RP. Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines. International Journal of Molecular Sciences. 2022;23(3):1706. https://doi.org/10.3390/ijms23031706
Ramírez-Plascencia OD, Saderi N, Cárdenas-Romero S, et al. Leptin and adiponectin regulate the activity of nuclei involved in sleep-wake cycle in male rats. Frontiers in Neuroscience. 2022;16:907508. https://doi.org/10.3389/fnins.2022.907508
Gafarov VV, Gromova EA, Panov DO, et al. Trends in sleep disturbances 1988—2018. among the population 25—64 years old in Russia/Siberia (WHO International Program «MONICA-psychosocial»). Nevrologija, nejropsihiatrija, psihosomatika. 2021;13(3):42-47. (In Russ.). https://doi.org/10.14412/2074-2711-2021-3-42-47
Tereshchenko IV. Leptin and its role in the body. Problemy Jendokrinologii. 2001;47(4):40-46. (In Russ.).
Tereshchenko IV, Kamenskikh YaA, Suslina AA. Adiponectin in health and disease. Terapevticheskij arhiv. 2016;88(12):126-132. (In Russ.). https://doi.org/10.17116/terarkh20168812126-132
Smetnev SA, Meshkov AN. The role of peptide hormones (adiponectin, leptin, insulin) in the pathogenesis of atherosclerosis. Racional’naja farmakoterapija v kardiologii. 2015;11(5):522-528. (In Russ.). https://doi.org/10.20996/1819-6446-2015-11-5-522-528
Brodskaya TA, Repina NI, Nevzorova VA, et al. Aortic stiffness and serum adipokine levels in individuals of European and South Asian ethnicity. Terapevticheskij arhiv. 2021;93(4):397-403. (In Russ.). https://doi.org/10.26442/00403660.2021.04.200679
Polonskaya YV, Kashtanova EV, Stakhneva EM, et al. Level adipokines in young people with arterial hypertension against the background of abdominal obesity. Arterial'naja gipertenzija. 2023;29(1):51-57. (In Russ.). https://doi.org/10.18705/1607-419X-2022-28-6-51-57
Ramírez-Plascencia OD, Saderi N, Cárdenas-Romero S, et al. Leptin and adiponectin regulate the activity of nuclei involved in sleep-wake cycle in male rats. Frontiers in Neuroscience. 2022;16:907508. https://doi.org/10.3389/fnins.2022.907508
Kvitkova LV, Borodkina DA, Gruzdeva OV, et al. The levels of leptin, adiponectin, and free fatty acids in the patients of different body weight presenting with myocardial infarction and elevated ST segment. Problemy jendokrinologii. 2013;59(3):8-12. (In Russ.). https://doi.org/10.14341/probl20135938-12
Nasledov A. SPSS 19: professional`ny`j statisticheskij analiz danny`x. SPb.: Piter; 2011. (In Russ.).
Stern JH, Grant AS, Thomson CA, et al. Short sleep duration is associated with decreased serum leptin, increased energy intake and decreased diet quality in postmenopausal women. Obesity (Silver Spring). 2014;22(5):E55-61. https://doi.org/10.1002/oby.20683
Motivala SJ, Tomiyama AJ, Ziegler M, et al. Nocturnal levels of ghrelin and leptin and sleep in chronic insomnia. Psychoneuroendocrinology. 2009; 34(4):540-545. https://doi.org/10.1016/j.psyneuen.2008.10.016
Reynolds AC, Dorrian J, Liu PY, et al. Impact of five nights of sleep restriction on glucose metabolism, leptin and testosterone in young adult men. PLoS One. 2012;7(7):e41218. https://doi.org/10.1371/journal.pone.0041218
Simpson NS, Banks S, Dinges DF. Sleep restriction is associated with increased morning plasma leptin concentrations, especially in women. Biological Research for Nursing. 2010;12(1):47-53. https://doi.org/10.1177/1099800410366301
Hayes AL, Xu F, Babineau D, et al. Sleep duration and circulating adipokine levels. Sleep. 2011;34(2):147-152. https://doi.org/10.1093/sleep/34.2.147
Pejovic S, Vgontzas AN, Basta M, et al. Leptin and hunger levels in young healthy adults after one night of sleep loss. Journal of Sleep Research. 2010; 19(4):552-558. https://doi.org/10.1111/j.1365-2869.2010.00844.x
Simpson NS, Banks S, Arroyo S, et al. Effects of sleep restriction on adiponectin levels in healthy men and women. Physiology and Behavior. 2010; 101(5):693-698. https://doi.org/10.1016/j.physbeh.2010.08.006