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Avdeev S.N.

Sechenov First Moscow State Medical University (Sechenov University);
Pulmonology Scientific Research Institute, Federal Medical and Biological Agency of Russia

Nuralieva G.S.

Sechenov First Moscow State Medical University (Sechenov University);
Research Institute for Pulmonology of the Federal Medical Biological Agency

High-flow nasal cannula therapy in patients with COPD

Authors:

Avdeev S.N., Nuralieva G.S.

More about the authors

Journal: Journal of Respiratory Medicine. 2025;1(2): 17‑38

DOI: 10.17116/respmed2025102117

Read: 1380 times

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Table of contents

HIGH-FLOW NASAL CANNULA THERAPY IN PATIENTS WITH COPD
HIGH-FLOW NASAL CANNULA THERAPY IN PATIENTS WITH COPD

To cite this article:

Avdeev SN, Nuralieva GS. High-flow nasal cannula therapy in patients with COPD. Journal of Respiratory Medicine. 2025;1(2):17‑38. (In Russ.)
https://doi.org/10.17116/respmed2025102117

Подписка 2026 Респираторная медицина (Journal of Respiratory Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Non-invasive ventilation (NIV) plays a critical role in the treatment of acute hypercapnic respiratory failure in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) by improving alveolar ventilation, reducing the work of breathing, minimizing the need for endotracheal intubation, and decreasing both the length of hospital stay and mortality. For patients intolerant to NIV, a trial of high-flow nasal cannula (HFNC) is recommended. High-flow nasal cannula therapy is a method of non-invasive respiratory support in which humidified, warmed, oxygen-enriched air is delivered through a nasal cannula at high flow rates. Several studies have investigated the physiological effects of HFNC in COPD patients and found that HFNC improves mucociliary clearance, decreases nasopharyngeal dead space, increases CO2 washout, and reduces respiratory effort. Recently, HFNC has gained popularity as a method of respiratory support and is increasingly used in daily clinical practice for patients with acute exacerbation of COPD. Although the clinical benefits of using HFNC at home are still poorly understood, some research results support the prospect of widespread use of HFNC in chronic respiratory diseases. The aim of this narrative review is to describe the physiological effects of HFNC and to highlight the results of key studies investigating the role of HFNC in patients with COPD.

Keywords:

COPD
high-flow nasal cannula
acute respiratory failure
chronic respiratory failure
inhalation therapy
pulmonary rehabilitation
aerosol therapy
palliative care

Authors:

Avdeev S.N.

Sechenov First Moscow State Medical University (Sechenov University);
Pulmonology Scientific Research Institute, Federal Medical and Biological Agency of Russia

Nuralieva G.S.

Sechenov First Moscow State Medical University (Sechenov University);
Research Institute for Pulmonology of the Federal Medical Biological Agency

Received:

06.05.2025

Accepted:

12.05.2025

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