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Shramko V.S.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Simonova G.I.

Research Institute of Internal and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics Siberian Division of the Russian Academy of Sciences

Khudiakova A.D.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Balanova Yu.A.

National Medical Research Center for Therapy and Preventive Medicine

Imaeva A.E.

National Medical Research Center for Therapy and Preventive Medicine

Shalnova S.A.

National Medical Research Center for Therapy and Preventive Medicine

Ragino Yu.I.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Associations of smoking status with the composition of fatty acids in blood plasma in men in Novosibirsk («ESSE-RF3» in the Novosibirsk region)

Authors:

Shramko V.S., Simonova G.I., Khudiakova A.D., Balanova Yu.A., Imaeva A.E., Shalnova S.A., Ragino Yu.I.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2024;27(6): 36‑41

DOI: 10.17116/profmed20242706136

Views: 568

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ASSOCIATIONS OF SMOKING STATUS WITH THE COMPOSITION OF FATTY ACIDS IN BLOOD PLASMA IN MEN IN NOVOSIBIRSK («ESSE-RF3» IN THE NOVOSIBIRSK REGION)
ASSOCIATIONS OF SMOKING STATUS WITH THE COMPOSITION OF FATTY ACIDS IN BLOOD PLASMA IN MEN IN NOVOSIBIRSK («ESSE-RF3» IN THE NOVOSIBIRSK REGION)

To cite this article:

Shramko VS, Simonova GI, Khudiakova AD, Balanova YuA, Imaeva AE, Shalnova SA, Ragino YuI. Associations of smoking status with the composition of fatty acids in blood plasma in men in Novosibirsk («ESSE-RF3» in the Novosibirsk region). Russian Journal of Preventive Medicine. 2024;27(6):36‑41. (In Russ.)
https://doi.org/10.17116/profmed20242706136

 
 
 
Подписка 2025-2 (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
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OBJECTIVE

To study the content of fatty acids (FAs) in blood plasma in men of Novosibirsk («ESSE-RF3» in the Novosibirsk region) depending on their smoking status.

MATERIAL AND METHODS

Men — residents of Novosibirsk (aged 35—74 years) were examined as part of the ESSE-RF3 multicenter cross-sectional epidemiological study in the Novosibirsk region. High-performance liquid chromatography in blood plasma was used to determine levels of omega-3 and omega-6 FAs in 226 men who are currently smoking (group I), in 256 men who smoked previously but could stop smoking (group II) and in 216 men who never smoked (group III).

RESULTS

In men of group I compared to men of group III, the levels of arachidonic and docosatetraenoic acids were higher by 13% (p=0.044) and 10% (p=0.045) respectively. Men of group II had higher levels of arachidonic, docosatetraenoic and docosapentaenoic FAs by 15% (p=0.034), 14% (p=0.036) and 15% (p=0.044) respectively. Results of logistic regression analysis have shown that the level of docosatetraenoic acid (omega-6) is directly associated, and the level of docosahexaenoic acid (omega-3) is inversely associated with the presence of bad habit in men, namely smoking.

CONCLUSION

Increase of omega-6 docosatetraenoic fatty acid level and decrease of omega-3 docosahexaenoic fatty acid level associated with smoking status can serve as an additional informative factor heightening the probability of cardiovascular diseases development.

Keywords:

fatty acids
lipid profile
blood
smoking
risk factors

Authors:

Shramko V.S.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Simonova G.I.

Research Institute of Internal and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics Siberian Division of the Russian Academy of Sciences

Khudiakova A.D.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Balanova Yu.A.

National Medical Research Center for Therapy and Preventive Medicine

Imaeva A.E.

National Medical Research Center for Therapy and Preventive Medicine

Shalnova S.A.

National Medical Research Center for Therapy and Preventive Medicine

Ragino Yu.I.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Received:

26.12.2023

Accepted:

24.01.2024

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