The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Polyakov D.P.

National Medical Research Center of Otorhinolaryngology of the Federal Medical-Biological Agency;
Pirogov Russian National Research Medical University

Daykhes N.A.

National Medical Research Center of Otorhinolaryngology of the Federal Medical-Biological Agency;
Pirogov Russian National Research Medical University

Yunusov A.S.

National Medical Research Center of Otorhinolaryngology of the Federal Medical-Biological Agency;
Pirogov Russian National Research Medical University

Gaganov L.E.

City Clinical Hospital No. 29 named after N.E. Bauman

Savlevich E.L.

Moscow Regional Clinical Research Institute named after M.F. Vladimirsky

Pogodina A.A.

Pirogov Russian National Research Medical University

Oganyan K.A.

Pirogov Russian National Research Medical University

Mitrofanova E.S.

Federal Scientific and Clinical Center of Specialized Types of Medical Care and Medical Technologies of the Federal Medical-Biological Agency

Pathomorphology of chronic polypous purulent rhinosinusitis in cystic fibrosis in children

Authors:

Polyakov D.P., Daykhes N.A., Yunusov A.S., Gaganov L.E., Savlevich E.L., Pogodina A.A., Oganyan K.A., Mitrofanova E.S.

More about the authors

Journal: Russian Rhinology. 2025;33(2): 101‑110

DOI: 10.17116/rosrino202533021101

Read: 661 times

Download PDF (RU)
Contact the author
Table of contents

PATHOMORPHOLOGY OF CHRONIC POLYPOUS PURULENT RHINOSINUSITIS IN CYSTIC FIBROSIS IN CHILDREN
PATHOMORPHOLOGY OF CHRONIC POLYPOUS PURULENT RHINOSINUSITIS IN CYSTIC FIBROSIS IN CHILDREN

To cite this article:

Polyakov DP, Daykhes NA, Yunusov AS, et al. . Pathomorphology of chronic polypous purulent rhinosinusitis in cystic fibrosis in children. Russian Rhinology. 2025;33(2):101‑110. (In Russ.)
https://doi.org/10.17116/rosrino202533021101

Подписка 2026 Российская ринология (Russian Rhinology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
On the issue of the etiology of acute inflammatory pathology of the pharynx in children. Russian Bulletin of Otorhinolaryngology. 2024;(5):10-15
Dive­rse mani­festations of orbi­tal pseudotumor in a six-year-old child (case study). Russian Annals of Ophthalmology. 2024;(5):106-111
Epidemiology of suicidal beha­vior in children and adolescents worldwide. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11-2):16-26
Diagnosis of neuroinfections in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11-2):51-59
Modern approaches to diagnosis and treatment of syndrome of auto­nomic dysfunction in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11-2):66-75
Studying the possibility of using methods for asse­ssing expressive speech deve­lopmental diso­rders in children 3—6 years old. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11-2):103-109
Inte­rnal hernias stra­ngulated in mese­nteric openings in young children. Piro­gov Russian Journal of Surgery. 2024;(11):54-59
The effect of sevo­flurane and propofol on serum nuclear and mito­chondrial DNA in pediatric patients with craniosynostosis. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):55-62
Problems of providing dental care to children using the example of the city of Chapaevsk, Samara region. Russian Journal of Operative Surgery and Clinical Anatomy. 2024;(4):35-42
Modern view on the etiology of gallstone disease in children. Russian Journal of Evidence-Based Gastroenterology. 2024;(4):59-68
Abstract:

Cystic fibrosis (CF) is a systemic autosomal recessive hereditary condition that is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Chronic rhinosinusitis, which is a source of infection of the underlying respiratory tract, is one of the main CF manifestations.

OBJECTIVE

To study the pathomorphological characteristics of the mucous membrane of the paranasal sinuses (PNSs) with polypoid changes in CF and compare them with nasal polyps in chronic rhinosinusitis with nasal polyps (CRSwNP) in children and adolescents without CF.

MATERIAL AND METHODS

The study included histological specimens obtained from 97 patients with a confirmed diagnosis of cystic fibrosis who underwent endoscopic endonasal sinus surgery. The control group consisted of 29 patients with CRSwNP without CF.

RESULTS

It has been established that intraepithelial microabscesses, intraepithelial microcysts and gland cysts were significantly more often detected in patients with CF compared to the subjects with CRSwNP. Patients with CF are characterized by lower eosinophil-neutrophil ratio (ENR) rates compared to subjects with CRSwNP. There has been no relationship between genotype and pathomorphological characteristics of the mucous membrane of the PNSs in CF.

CONCLUSION

The presence of intraepithelial microabscesses, intraepithelial microcysts and gland cysts can be considered as a pathomorphological marker of CF. Identification of these histological features in combination with a low value of the ENR will allow to suspect CF in patients with CRSwNP. Low ENR rates in patients with CF were suggestive of intranasal glucocorticosteroids’ insufficient effectiveness in the treatment of patients with this disease.

Keywords:

cystic fibrosis
chronic rhinosinusitis (CRS)
chronic rhinosinusitis with nasal polyps (CRSwNP)
pathomorphology
eosinophil-neutrophil ratio (ENR)
children

Authors:

Polyakov D.P.

National Medical Research Center of Otorhinolaryngology of the Federal Medical-Biological Agency;
Pirogov Russian National Research Medical University

Daykhes N.A.

National Medical Research Center of Otorhinolaryngology of the Federal Medical-Biological Agency;
Pirogov Russian National Research Medical University

Yunusov A.S.

National Medical Research Center of Otorhinolaryngology of the Federal Medical-Biological Agency;
Pirogov Russian National Research Medical University

Gaganov L.E.

City Clinical Hospital No. 29 named after N.E. Bauman

Savlevich E.L.

Moscow Regional Clinical Research Institute named after M.F. Vladimirsky

Pogodina A.A.

Pirogov Russian National Research Medical University

Oganyan K.A.

Pirogov Russian National Research Medical University

Mitrofanova E.S.

Federal Scientific and Clinical Center of Specialized Types of Medical Care and Medical Technologies of the Federal Medical-Biological Agency

Received:

10.05.2024

Accepted:

17.06.2024

Close metadata

References:

  1. Cystic fibrosis. 2nd edition, revised and supplemented. Edited by N.Yu. Kashirskaya, N.I. Kapranov and E.I. Kondratieva. Moscow: MEDPRAKTIKA-M; 2021. (In Russ.).
  2. Schraven SP, Wehrmann M, Wagner W, Blumenstock G, Koitschev A. Prevalence and histopathology of chronic polypoid sinusitis in pediatric patients with cystic fibrosis. J Cyst Fibros. 2011;10(3):181-6.  https://doi.org/10.1016/j.jcf.2011.01.003
  3. Polyakov DP, Voronkova AYu, Savlevich EL, Gerasimov AN, Kondratyeva EI. Microbiological characteristics of chronic rhinosinusitis in children with cystic fibrosis comparing with other parts of the respiratory tract. Voprosy prakticheskoy pediatrii = Clinical Practice in Pediatrics. 2023;18(1):62-71. (In Russ.). https://doi.org/10.20953/1817-7646-2023-1-62-71
  4. Kozlov VS, Savlevich EL. Chronic rhinosinusitis with nasal polyps. The recent trend in the studies of the pathogenesis, diagnosis and treatment of this disease. Russian Bulletin of Otorhinolaryngology. 2015;80(4):95-99. (In Russ.). https://doi.org/10.17116/otorino201580495-99
  5. Savlevich EL, Gaganov LE, Gerasimov AN, Kurbacheva OM, Egorov VI, Zurochka AV. Analysis of clinical course of chronic rhinosinusitis with nasal polyp (CRSWNP) and pathomorphological composition of nasal polyp tissue in patients living in different regions of the Russian Federation. Head and neck. Russian Journal. 2021;9(3):15-24 (In Russ.). https://doi.org/10.25792/HN.2021.9.3.15-24
  6. Sitzia E, Santarsiero S, Marini G, Majo F, De Vincentiis M, Cristalli G, Artesani MC, Fiocchi AG. Endotypes of Nasal Polyps in Children: A Multidisciplinary Approach. J Pers Med. 2023;13(5):707.  https://doi.org/10.3390/jpm13050707
  7. Boiko NV. Clinical characteristics of antrochoanal polyps: case reports and a review of literature. Russian Rhinology. 2016;24(3):52-56. (In Russ.). https://doi.org/10.17116/rosrino201624352-56
  8. Zolotova TV, Kirichenko UG. Clinicopathologic Characteristic of Large Antrochoanal Polyps. Medical Herald of the South of Russia. 2012;(2):53-56. (In Russ.).
  9. Gysin C, Alothman GA, Papsin BC. Sinonasal disease in cystic fibrosis: Clinical characteristics, diagnosis, and management. Pediatr Pulmonol. 2000;30:481-489.  https://doi.org/10.1002/1099-0496(200012)30:6<481::AID-PPUL8>3.0.CO;2-N
  10. Scapa VI, Ramakrishnan VR, Kingdom TT. Upregulation of Bcl-2 in nasal polyps from patients with cystic fibrosis. Int Forum Allergy Rhinol. 2013; 3(3):199-203.  https://doi.org/10.1002/alr.21107
  11. Hauber H-P, Manoukian JJ, Nguyen LHP, Sobol SE, Levitt RC, Holroyd KJ, McElvaney NG, Griffin S, Hamid Q. Increased Expression of Interleukin-9, Interleukin-9 Receptor, and the Calcium-Activated Chloride Channel hCLCA1 in the Upper Airways of Patients With Cystic Fibrosis. Laryngoscope. 2003;113:1037-1042. https://doi.org/10.1097/00005537-200306000-00022
  12. Skinner ML, Schlosser RJ, Lathers D, Neal JG, Woodworth BA, Hall J, Newton DA, Baatz JE. Innate and Adaptive Mediators in Cystic Fibrosis and Allergic Fungal Rhinosinusitis. American Journal of Rhinology. 2007;21(5):538-541.  https://doi.org/10.2500/ajr.2007.21.3070
  13. Beiersdorf N, Schien M, Hentschel J, Pfister W, Markert UR, Mainz JG. Soluble inflammation markers in nasal lavage from CF patients and healthy controls. J Cyst Fibros. 2013;12(3):249-257.  https://doi.org/10.1016/j.jcf.2012.08.015
  14. Knipping S, Holzhausen HJ, Riederer A, Bloching M. Cystic fibrosis: ultrastructural changes of nasal mucosa. Eur Arch Otorhinolaryngol. 2007; 264(12):1413-1418. https://doi.org/10.1007/s00405-007-0393-y
  15. Mir-Salim PA, Merker HJ, Jahnke V, Berghaus A. Die Drüsen der menschlichen Nasenschleimhaut-elektronenmikroskopische und immunhistochemische Untersuchungen [Glands of the human nasal mucosa-electron microscopy and immunohistochemical studies]. Laryngorhinootologie. 1998 ;77(6): 322-3227. (In German). https://doi.org/10.1055/s-2007-996981
  16. Steinke JW, Payne SC, Chen PG, Negri J, Stelow EB, Borish L. Etiology of nasal polyps in cystic fibrosis: not a unimodal disease. Ann Otol Rhinol Laryngol. 2012;121(9):579-586.  https://doi.org/10.1177/000348941212100904
  17. Beju D, Meek WD, Kramer JC. The ultrastructure of the nasal polyps in patients with and without cystic fibrosis. J Submicrosc Cytol Pathol. 2004; 36(2):155-165. 
  18. Henderson WR Jr, Chi EY. Degranulation of cystic fibrosis nasal polyp mast cells. J Pathol. 1992;166(4):395-404.  https://doi.org/10.1002/path.1711660412
  19. Kim RJ, Park L, Wood AJ, Yin T, Jain R, Douglas RG. Chronic rhinosinusitis and cystic fibrosis: the interaction between sinus bacteria and mucosal immunity. Int Forum Allergy Rhinol. 2015;5(5):380-385.  https://doi.org/10.1002/alr.21431
  20. Sendi P, Proctor RA. Staphylococcus aureus as an intracellular pathogen: the role of small colony variants. Trends Microbiol. 2009;17(2):54-58.  https://doi.org/10.1016/j.tim.2008.11.004
  21. Taylor AL, Llewelyn MJ. Superantigen-induced proliferation of human CD4+CD25- T cells is followed by a switch to a functional regulatory phenotype. J Immunol. 2010;185(11):6591-6598. https://doi.org/10.4049/jimmunol.1002416
  22. Anwar S, Prince LR, Foster SJ, Whyte MK, Sabroe I. The rise and rise of Staphylococcus aureus: laughing in the face of granulocytes. Clin Exp Immunol. 2009;157(2):216-224.  https://doi.org/10.1111/j.1365-2249.2009.03950.x
  23. Rezende GL, Nakanishi M, Couto SCP, Martins CLFS, Sampaio ALL, Albuquerque LFF, Kückelhaus SAS, Muniz-Junqueira MI. Alterations in innate immune responses of patients with chronic rhinosinusitis related to cystic fibrosis. PLoS One. 2022;17(5):e0267986. https://doi.org/10.1371/journal.pone.0267986
  24. Tos M, Mogensen C, Thomsen J. Nasal polyps in cystic fibrosis. J Laryngol Otol. 1977 Oct;91(10):827-835.  https://doi.org/10.1017/s0022215100084449
  25. Rowe-Jones JM, Shembekar M, Trendell-Smith N, Mackay IS. Polypoidal rhinosinusitis in cystic fibrosis: a clinical and histopathological study. Clin Otolaryngol Allied Sci. 1997;22(2):167-171.  https://doi.org/10.1046/j.1365-2273.1997.00003.x
  26. https://doi.org/10.36691/RJA1198  https://doi.org/10.36691/RJA1198
  27. Savlevich EL, Gaganov LV, Egorov VI, Kurbacheva OM, Mitrofanova ES, Pelishenko TG, Lyubimova EV. Application of eosinophil-neutrophil index eni and degree of inflammatory infiltration to assess the inflammatory process in polypous rhinosinusitis. Rossiiskaya otorinolaringologiya. 2022; 21(5):70-81. (In Russ.). https://doi.org/10.18692/1810-4800-2022-5-70-81
  28. Marson FAL, Bertuzzo CS, Ribeiro JD. Classification of CFTR mutation classes. Lancet Respir Med. 2016;4(8):e37-e38.  https://doi.org/10.1016/S2213-2600(16)30188-6
  29. Petrova NV, Kondratyeva EI, Polyakov AV ? et al. Features of spectrum of pathogenic genetic variants of the CFTR gene in patients with cystic fibrosis from the Russian Federation. Siberian Medical Review. 2019;(2):47-59.  https://doi.org/10.20333/2500136-2019-2-47-59
  30. Baranov AA, Namazova-Baranova LS, Kutsev SI, et al. Modern Approaches in Management of Children with Cystic fibrosis. Pediatric pharmacology. 2022;19(2):153-195. (In Russ.). https://doi.org/10.15690/pf.v19i2.2417
  31. Weinstock MS, Shaffer AD, Stapleton AL. Predictors of sinonasal disease onset, progression, and severity in pediatric cystic fibrosis patients. Am J Otolaryngol. 2021;42(5):103016. https://doi.org/10.1016/j.amjoto.2021.103016
  32. Do BA, Lands LC, Saint-Martin C, Mascarella MA, Manoukian JJ, Daniel SJ, Nguyen LH. Effect of the F508del genotype on outcomes of endoscopic sinus surgery in children with cystic fibrosis. Int J Pediatr Otorhinolaryngol. 2014;78(7):1133-1137. https://doi.org/10.1016/j.ijporl.2014.04.030
  33. Polyakov DP, Daykhes NA, Yunusov AS, Karneyeva OV, Kondrat’yeva EI, Petrov AS, Belavina PI, Ryazanskaya AG, Molodtsova EV. Rhinosinusosurgery in children with cystic fibrosis. Head and neck. Russian Journal. 2021; 9(1):35–44 (In Russ.).
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.