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Gavrilov K.A.

Center of New Medical Technologies;
Novosibirsk State University

Smetanina M.A.

Novosibirsk State University;
Institute of Chemical Biology and Fundamental Medicine

Korolenya V.A.

Novosibirsk State University;
Institute of Chemical Biology and Fundamental Medicine

Sevostyanova K.S.

Center of New Medical Technologies;
Novosibirsk State University

Filipenko M.L.

Institute of Chemical Biology and Fundamental Medicine

Shevela A.I.

Center of New Medical Technologies;
Novosibirsk State University;
Institute of Chemical Biology and Fundamental Medicine

Molecular Genetic Aspects of Varicose Vein Disease: Modern Concepts

Authors:

Gavrilov K.A., Smetanina M.A., Korolenya V.A., Sevostyanova K.S., Filipenko M.L., Shevela A.I.

More about the authors

Journal: Journal of Venous Disorders. 2024;18(1): 48‑53

DOI: 10.17116/flebo20241801148

Views: 803

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To cite this article:

Gavrilov KA, Smetanina MA, Korolenya VA, Sevostyanova KS, Filipenko ML, Shevela AI. Molecular Genetic Aspects of Varicose Vein Disease: Modern Concepts. Journal of Venous Disorders. 2024;18(1):48‑53. (In Russ.)
https://doi.org/10.17116/flebo20241801148

Подписка 2025 (Journal of Venous Disorders)
 
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Varicose veins disease is widespread and affects all segments of population. Researchers are actively looking for molecular genetic mechanisms of this disease. Nevertheless, pathogenesis is still not completely clear. The authors describe the most interesting researches devoted to genetics and molecular technologies related to varicose veins over the past 5 years. Of course, this review does not clearly define pathogenesis of disease. In addition to collection of material and databases, many authors analyze the issue of regulation of gene expression. PIEZO1 gene is one of the perspective ones. Its rare variant (PTV) correlated with necessary surgical treatment of varicose veins. Many authors have been recently interested in regulatory RNAs. Their role is obvious in pathogenesis of varicose veins and complications. The most interesting ones are miR-202, miR-1202 and miR-661. Homeostasis of organism and its regulation are also important. Evidence of relationship between changes of certain microelements with development or aggravation of varicose veins requires adequate sample of patients and searching for interrelations. To date, the role of calcium in venous ulcers has been almost confirmed. Genetic analysis of varicose veins is important for understanding the pathology and selecting the most effective prevention, diagnostics and treatment. All this will further enable the fullest activation of all aspects of personalized medicine.

Keywords:

varicose veins
molecular genetic markers
pathogenesis

Authors:

Gavrilov K.A.

Center of New Medical Technologies;
Novosibirsk State University

Smetanina M.A.

Novosibirsk State University;
Institute of Chemical Biology and Fundamental Medicine

Korolenya V.A.

Novosibirsk State University;
Institute of Chemical Biology and Fundamental Medicine

Sevostyanova K.S.

Center of New Medical Technologies;
Novosibirsk State University

Filipenko M.L.

Institute of Chemical Biology and Fundamental Medicine

Shevela A.I.

Center of New Medical Technologies;
Novosibirsk State University;
Institute of Chemical Biology and Fundamental Medicine

Received:

23.12.2023

Accepted:

05.01.2024

List of references:

  1. Raetz J, Wilson M, Collins K. Varicose Veins: Diagnosis and Treatment. Am Fam Physician. 2019;99(11):682-688. 
  2. Salim S, Machin M, Patterson BO, Onida S, Davies AH. Global Epidemiology of Chronic Venous Disease: A Systematic Review With Pooled Prevalence Analysis. Ann Surg. 2021;274(6):971-976.  https://doi.org/10.1097/SLA.0000000000004631
  3. Youn YJ, Lee J. Chronic venous insufficiency and varicose veins of the lower extremities. Korean J Intern Med. 2019;34(2):269-283.  https://doi.org/10.3904/kjim.2018.230
  4. Malgor RD, Labropoulos N. Diagnosis and follow-up of varicose veins with duplex ultrasound: how and why? Phlebology. 2012;27(suppl 1):10-15.  https://doi.org/10.1258/phleb.2011.012s05
  5. Gloviczki P, Lawrence PF, Wasan SM, Meissner MH, Almeida J, Brown KR, Bush RL, Di Iorio M, Fish J, Fukaya E, Gloviczki ML, Hingorani A, Jayaraj A, Kolluri R, Murad MH, Obi AT, Ozsvath KJ, Singh MJ, Vayuvegula S, Welch HJ. The 2022 Society for Vascular Surgery, American Venous Forum, and American Vein and Lymphatic Society clinical practice guidelines for the management of varicose veins of the lower extremities. Part I. Duplex Scanning and Treatment of Superficial Truncal Reflux: Endorsed by the Society for Vascular Medicine and the International Union of Phlebology. J Vasc Surg Venous Lymphat Disord. 2023;11(2):231-261.e6.  https://doi.org/10.1016/j.jvsv.2022.09.004
  6. Brinsuk M, Tank J, Luft FC, Busjahn A, Jordan J. Heritability of venous function in humans. Arterioscler Thromb Vasc Biol. 2004;24(1):207-11.  https://doi.org/10.1161/01.ATV.0000107080.48969.64
  7. Fukaya E, Flores AM, Lindholm D, Gustafsson S, Zanetti D, Ingelsson E, Leeper NJ. Clinical and Genetic Determinants of Varicose Veins. Circulation. 2018;138(25):2869-2880. https://doi.org/10.1161/CIRCULATIONAHA.118.035584
  8. Serra R, Ssempijja L, Provenzano M, Andreucci M. Genetic biomarkers in chronic venous disease. Biomark Med. 2020;14(2):75-80.  https://doi.org/10.2217/bmm-2019-0408
  9. Bharath V, Kahn S, Lazo-Langner A. Genetic polymorphisms of vein wall remodeling in chronic venous disease: a narrative and systematic review. Blood. 2014;124(8):1242-1250. https://doi.org/10.1182/blood-2014-03-558478
  10. Lim C, Davies A. Pathogenesis of primary varicose veins. British Journal of Surgery. 2009;96(11):1231-1242. https://doi.org/10.1002/bjs.6798
  11. Ng M. Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. J Med Genet. 2005;42(3):235-239.  https://doi.org/10.1136/jmg.2004.024075
  12. Surendran S, Girijamma A, Nair R et al. Forkhead box C2 promoter Cariant c.-512C>T is associated with increased susceptibility to chronic venous diseases. PLoS ONE. 2014;9(3):e90682. https://doi.org/10.1371/journal.pone.0090682
  13. Shadrina AS, Zolotukhin IA, Filipenko ML. Molecular mechanisms underlying the development of varicose veins of low extremities. Flebologiya. 2017;11(2):71-75. (In Russ.). https://doi.org/10.17116/flebo201711271-75
  14. Lee ML, Liang C, Chuang CH, Lee PS, Chen TH, Sun S, Liao KW, Huang HD. A genome-wide association study for varicose veins. Phlebology. 2022;37(4):267-278.  https://doi.org/10.1177/02683555211069248
  15. Shadrina AS, Smetanina MA, Sevost’ianova KS, Seliverstov EI, Ilyukhin EA, Voronina EN, Zolotukhin IA, Filipenko ML. Functional polymorphism rs1024611 in the MCP1 gene is associated with the risk of varicose veins of lower extremities. J Vasc Surg Venous Lymphat Disord. 2017;5(4):561-566.  https://doi.org/10.1016/j.jvsv.2016.12.008
  16. Pai AA, Pritchard JK, Gilad Y. The genetic and mechanistic basis for variation in gene regulation. PLoS Genet. 2015;11(1):e1004857. https://doi.org/10.1371/journal.pgen.1004857
  17. Garieri M, Delaneau O, Santoni F, Fish RJ, Mull D, Carninci P, Dermitzakis ET, Antonarakis SE, Fort A. The effect of genetic variation on promoter usage and enhancer activity. Nat Commun. 2017;8(1):1358. https://doi.org/10.1038/s41467-017-01467-7
  18. Brandt M, Lappalainen T. SnapShot: Discovering Genetic Regulatory Variants by QTL Analysis. Cell. 2017;171(4):980-980.e1.  https://doi.org/10.1016/j.cell.2017.10.031
  19. Kang H, Hong Z, Zhong M, Klomp J, Bayless KJ, Mehta D, Karginov AV, Hu G, Malik AB. Piezo1 mediates angiogenesis through activation of MT1-MMP signaling. Am J Physiol Cell Physiol. 2019;316(1):C92-C103. https://doi.org/10.1152/ajpcell.00346.2018
  20. Holt JR, Zeng WZ, Evans EL, Woo SH, Ma S, Abuwarda H, Loud M, Patapoutian A, Pathak MM. Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing. Elife. 2021;10:e65415. https://doi.org/10.7554/eLife.65415
  21. Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of posttranscriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet. 2008;9:102-114.  https://doi.org/10.1038/nrg2290
  22. Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into functions. Nat Rev Genet. 2009;10:155-159.  https://doi.org/10.1038/nrg2521
  23. Eddy SR. Non-coding RNA genes and the modern RNA world. Nat Rev Genet. 2001;2:919-929.  https://doi.org/10.1038/35103511
  24. Serra R, Ssempijja L, Provenzano M, Andreucci M. Genetic biomarkers in chronic venous disease. Biomark Med. 2020;14(2):75-80.  https://doi.org/10.2217/bmm-2019-0408
  25. Wu J, Li X, Li D, Ren X, Li Y, Herter EK, Qian M, Toma MA, Wintler AM, Sérézal IG, Rollman O, Ståhle M, Wikstrom JD, Ye X, Landén NX. MicroRNA-34 Family Enhances Wound Inflammation by Targeting LGR4. J Invest Dermatol. 2020;140(2):465-476.e11.  https://doi.org/10.1016/j.jid.2019.07.694
  26. Filipowska J, Kondegowda NG, Leon-Rivera N, Dhawan S, Vasavada RC. LGR4, a G Protein-Coupled Receptor With a Systemic Role: From Development to Metabolic Regulation. Front Endocrinol (Lausanne). 2022;13:867001. https://doi.org/10.3389/fendo.2022.867001
  27. Huang X, Liu Z, Shen L, Jin Y, Xu G, Zhang Z, Fang C, Guan W, Liu C. Augmentation of miR-202 in varicose veins modulates phenotypic transition of vascular smooth muscle cells by targeting proliferator-activated receptor-γ coactivator-1α. J Cell Biochem. 2019;120(6):10031-10042. https://doi.org/10.1002/jcb.28287
  28. Akar I, Ince I, Aslan C, Benli I, Demir O, Altındeger N, Dogan A, Ceber M. Oxidative stress and prolidase enzyme activity in the pathogenesis of primary varicose veins. Vascular. 2018;26(3):315-321.  https://doi.org/10.1177/1708538117741764
  29. Scarpulla RC. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta. 2011;1813(7): 1269-1278. https://doi.org/10.1016/j.bbamcr.2010.09.019
  30. Shoag J, Arany Z. Regulation of hypoxia-inducible genes by PGC-1 alpha. Arterioscler Thromb Vasc Biol. 2010;30(4):662-666.  https://doi.org/10.1161/ATVBAHA.108.181636
  31. Xu W, Guo T, Zhang Y, Jiang X, Zhang Y, Zen K, Yu B, Zhang CY. The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1α expression. Exp Cell Res. 2011;317(8):1083-1092. https://doi.org/10.1016/j.yexcr.2010.10.006
  32. Eisele PS, Salatino S, Sobek J, Hottiger MO, Handschin C. The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. J Biol Chem. 2013;288(4):2246-2260. https://doi.org/10.1074/jbc.M112.375253
  33. Schilling J, Kelly DP. The PGC-1 cascade as a therapeutic target for heart failure. J Mol Cell Cardiol. 2011;51(4):578-583.  https://doi.org/10.1016/j.yjmcc.2010.09.021
  34. Li C, Xu YH, Hu YT, Zhou X, Huang ZS, Ye JM, Rao Y. Matrine counteracts obesity in mice via inducing adipose thermogenesis by activating HSF1/PGC-1α axis. Pharmacol Res. 2022;177:106136. https://doi.org/10.1016/j.phrs.2022.106136
  35. Smetanina MA, Kel AE, Sevost’ianova KS, Maiborodin IV, Shevela AI, Zo- lotukhin IA, Stegmaier P, Filipenko ML. DNA methylation and gene expression profiling reveal MFAP5 as a regulatory driver of extracellular matrix remodeling in varicose vein disease. Epigenomics. 2018;10(8):1103-1119. https://doi.org/10.2217/epi-2018-0001
  36. Biranvand AS, Khosravi M, Esfandiari G, Poursaleh A, Hosseini-Fard SR, Amirfarhangi A, Najafi M. Associations between miR-661, miR-1202, lncRNA-HOTAIR, lncRNA-GAS5 and MMP9 in differentiated M2-macrophages of patients with varicose veins. Int Angiol. 2018;37(6):451-456.  https://doi.org/10.23736/S0392-9590.18.04022-1
  37. Smith K, Hewlings S. Correlation between vitamin D levels and hard-to-heal wounds: a systematic review. J Wound Care. 2021;30(suppl 6):S4-S10.  https://doi.org/10.12968/jowc.2021.30.Sup6.S4
  38. Yuan S, Bruzelius M, Damrauer SM, Larsson SC. Cardiometabolic, Lifestyle, and Nutritional Factors in Relation to Varicose Veins: A Mendelian Randomization Study. J Am Heart Assoc. 2021;10(21):e022286. https://doi.org/10.1161/JAHA.121.022286
  39. Ferris AE, Harding KG. An overview of the relationship between anaemia, iron, and venous leg ulcers. Int Wound J. 2019;16(6):1323-1329. https://doi.org/10.1111/iwj.13192

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