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Fayzrakhmanov R.R.

National Medical and Surgical Center named after N.I. Pirogov

Shishkin M.M.

National Medical and Surgical Center named after N.I. Pirogov

Saraeva S.N.

National Medical and Surgical Center named after N.I. Pirogov

A modern perspective on the pathogenesis of proliferative diabetic retinopathy

Authors:

Fayzrakhmanov R.R., Shishkin M.M., Saraeva S.N.

More about the authors

Journal: Russian Annals of Ophthalmology. 2025;141(1): 92‑98

DOI: 10.17116/oftalma202514101192

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Table of contents

A MODERN PERSPECTIVE ON THE PATHOGENESIS OF PROLIFERATIVE DIABETIC RETINOPATHY
A MODERN PERSPECTIVE ON THE PATHOGENESIS OF PROLIFERATIVE DIABETIC RETINOPATHY

To cite this article:

Fayzrakhmanov RR, Shishkin MM, Saraeva SN. A modern perspective on the pathogenesis of proliferative diabetic retinopathy. Russian Annals of Ophthalmology. 2025;141(1):92‑98. (In Russ.)
https://doi.org/10.17116/oftalma202514101192

Подписка 2025-2 (Russian Annals of Ophthalmology)
 
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This article reviews the pathogenic mechanisms underlying proliferative diabetic retinopathy (DR), focusing on the development of angio-fibrotic switch, neurodegeneration, pro-inflammatory and pro-angiogenic biomarkers, emphasizes the modern perspectives on the role of the vitreous body and mechanical traction in DR progression. Understanding of these pathogenic mechanisms will provide new opportunities for improvement and development of treatments for DR at earlier stages, before significant and persistent functional impairment occurs.

Keywords:

proliferative diabetic retinopathy
angio-fibrotic switch
pathogenesis
vitreoretinopathy

Authors:

Fayzrakhmanov R.R.

National Medical and Surgical Center named after N.I. Pirogov

Shishkin M.M.

National Medical and Surgical Center named after N.I. Pirogov

Saraeva S.N.

National Medical and Surgical Center named after N.I. Pirogov

Received:

11.09.2024

Accepted:

25.09.2024

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