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Fayzrakhmanov R.R.
National Medical and Surgical Center named after N.I. Pirogov
Shishkin M.M.
National Medical and Surgical Center named after N.I. Pirogov
Saraeva S.N.
National Medical and Surgical Center named after N.I. Pirogov
A modern perspective on the pathogenesis of proliferative diabetic retinopathy
Journal: Russian Annals of Ophthalmology. 2025;141(1): 92‑98
Read: 707 times
To cite this article:
Fayzrakhmanov RR, Shishkin MM, Saraeva SN. A modern perspective on the pathogenesis of proliferative diabetic retinopathy. Russian Annals of Ophthalmology.
2025;141(1):92‑98. (In Russ.)
https://doi.org/10.17116/oftalma202514101192
This article reviews the pathogenic mechanisms underlying proliferative diabetic retinopathy (DR), focusing on the development of angio-fibrotic switch, neurodegeneration, pro-inflammatory and pro-angiogenic biomarkers, emphasizes the modern perspectives on the role of the vitreous body and mechanical traction in DR progression. Understanding of these pathogenic mechanisms will provide new opportunities for improvement and development of treatments for DR at earlier stages, before significant and persistent functional impairment occurs.
Authors:
Fayzrakhmanov R.R.
National Medical and Surgical Center named after N.I. Pirogov
Shishkin M.M.
National Medical and Surgical Center named after N.I. Pirogov
Saraeva S.N.
National Medical and Surgical Center named after N.I. Pirogov
Received:
11.09.2024
Accepted:
25.09.2024
List of references:
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