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Fayzrakhmanov R.R.

National Medical and Surgical Center named after N.I. Pirogov

Shishkin M.M.

National Medical and Surgical Center named after N.I. Pirogov

Saraeva S.N.

National Medical and Surgical Center named after N.I. Pirogov

A modern perspective on the pathogenesis of proliferative diabetic retinopathy

Authors:

Fayzrakhmanov R.R., Shishkin M.M., Saraeva S.N.

More about the authors

Journal: Russian Annals of Ophthalmology. 2025;141(1): 92‑98

DOI: 10.17116/oftalma202514101192

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Table of contents

A MODERN PERSPECTIVE ON THE PATHOGENESIS OF PROLIFERATIVE DIABETIC RETINOPATHY
A MODERN PERSPECTIVE ON THE PATHOGENESIS OF PROLIFERATIVE DIABETIC RETINOPATHY

To cite this article:

Fayzrakhmanov RR, Shishkin MM, Saraeva SN. A modern perspective on the pathogenesis of proliferative diabetic retinopathy. Russian Annals of Ophthalmology. 2025;141(1):92‑98. (In Russ.)
https://doi.org/10.17116/oftalma202514101192

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This article reviews the pathogenic mechanisms underlying proliferative diabetic retinopathy (DR), focusing on the development of angio-fibrotic switch, neurodegeneration, pro-inflammatory and pro-angiogenic biomarkers, emphasizes the modern perspectives on the role of the vitreous body and mechanical traction in DR progression. Understanding of these pathogenic mechanisms will provide new opportunities for improvement and development of treatments for DR at earlier stages, before significant and persistent functional impairment occurs.

Keywords:

proliferative diabetic retinopathy
angio-fibrotic switch
pathogenesis
vitreoretinopathy

Authors:

Fayzrakhmanov R.R.

National Medical and Surgical Center named after N.I. Pirogov

Shishkin M.M.

National Medical and Surgical Center named after N.I. Pirogov

Saraeva S.N.

National Medical and Surgical Center named after N.I. Pirogov

Received:

11.09.2024

Accepted:

25.09.2024

Close metadata

References:

  1. Neroev VV, Zaitseva OV, Mikhailova LA. Diabetic retinopathy prevalence in the Russian Federation according to all-Russia statistics. Rossiiskii oftal’mologicheskii zhurnal. 2023;16(3):7-11 (In Russ.). https://doi.org/10.21516/2072-0076-2023-16-3-7-11
  2. Sabanayagam C, Banu R, Chee ML, Lee R, Wang YX, Tan G, Jonas JB, Lamoureux EL, Cheng CY, Klein BEK, Mitchell P, Klein R, Cheung CMG, Wong TY. Incidence and progression of diabetic retinopathy: a systematic review. Lancet Diabetes Endocrinol. 2019;7(2):140-149.  https://doi.org/10.1016/S2213-8587(18)30128-1
  3. Zhou AY, Zhou CJ, Yao J, Quan YL, Ren BC, Wang JM. Panretinal photocoagulation versus panretinal photocoagulation plus intravitreal bevacizumab for high-risk proliferative diabetic retinopathy. Int J Med Ophthalmol. 2016;9(12):1772-1778. https://doi.org/10.18240/ijo.2016.12.12
  4. Someya H, Takayama K, Takeuchi M, Yokoyama H, Kimura T, Morioka M, Takamura Y, Sameshima S, Ueda T, Ogata N, Tashiro M, Kitano S, Sakamoto T. Outcomes of 25-Gauge Vitrectomy for Tractional and Nontractional Diabetic Macular Edema with Proliferative Diabetic Retinopathy. J Ophthalmol. 2019;2019:5304524. https://doi.org/10.1155/2019/5304524
  5. Wong TY, Cheung CM, Larsen M, Sharma S, Simó R. Diabetic retinopathy. Nat Rev Dis Primers. 2016;2:16012. https://doi.org/10.1038/nrdp.2016.12
  6. All-Russian public organization “Association of Ophthalmologists”, public organization “Russian Association of Endocrinologists”. Diabetes mellitus: diabetic retinopathy, diabetic macular edema. Clinical guidelines (treatment protocols). Accessed 24.08.2024 (In Russ.). https://cr.minzdrav.gov.ru/recomend/114_2
  7. Madonna R, De Caterina R. Cellular and molecular mechanisms of vascular injury in diabetes — part I: pathways of vascular disease in diabetes. Vascul Pharmacol. 2011;54:68-74.  https://doi.org/10.1016/j.vph.2011.03.005
  8. Madonna R, Balistreri CR, Geng YJ, De Caterina R. Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches. Vascul Pharmacol. 2017;90:1-7.  https://doi.org/10.1016/j.vph.2017.01.004
  9. Barber AJ, Lieth E, Khin SA, Antonetti DA, Buchanan AG, Gardner TW. Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J Clin Investig. 1998;102(4):783-791.  https://doi.org/10.1172/JCI2425
  10. Xiao C, He M, Nan Y, Zhang D, Chen B, Guan Y, Pu M. Physiological effects of superoxide dismutase on altered visual function of retinal ganglion cells in db/db mice. PLoS One 2012;7(1):e30343. https://doi.org/10.1371/journal.pone.0030343
  11. Nawaz IM, Rezzola S, Cancarini A, Russo A, Costagliola C, Semeraro F, Presta M. Human vitreous in proliferative diabetic retinopathy: Characterization and translational implications. Progr Retin Eye Res. 2019;72:100756. https://doi.org/10.1016/j.preteyeres.2019.03.002
  12. Gardner TW, Davila JR. The neurovascular unit and the pathophysiologic basis of diabetic retinopathy. Graefe’s Arch Clin Exper Ophthalmol. 2017; 255(1):1-6.  https://doi.org/10.1007/s00417-016-3548-y
  13. Filippov VM, Petrachkov DV, Budzinskaya MV, Matyushchenko AG. The role of neurodegeneration biomarkers in the management of patients with diabetic retinopathy. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 2021;137(5-2):314-322. (In Russ.). https://doi.org/10.17116/oftalma2021137052314
  14. Petrachkov DV, Budzinskaya MV, Pavlov VG, Durzhinskaya MH, Khalatyan AS. Neurodegenerative biomarkers of the response to diabetic macular edema treatment. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 2020;136(4):201-206 (In Russ.). https://doi.org/10.17116/oftalma2020136042201
  15. Joussen AM, Poulaki V, Le ML, Koizumi K, Esser C, Janicki H, Schraermeyer U, Kociok N, Fauser S, Kirchhof B, Kern TS, Adamis AP. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 2004;18(12):1450-1452. https://doi.org/10.1096/fj.03-1476fje
  16. Stewart MW. Pathophysiology of Diabetic Retinopathy. In: Browning D. (ed.). Diabetic Retinopathy. New York, NY: Springer; 2010. P. 1-30.  https://doi.org/10.1007/978-0-387-85900-2_1
  17. Bruno L, Marco R, Maria CS. Diabetic Retinopathy. New Delhi, India: Jaypee Brothers Medical Publishers Pvt. Ltd.; 2015. P. 110. 
  18. Selim KM, Sahan D, Muhittin T, Osman C, Mustafa O. Increased levels of vascular endothelial growth factor in the aqueous humor of patients with diabetic retinopathy. Indian J Ophthalmol. 2010;58(5):375-379.  https://doi.org/10.4103/0301-4738.67042
  19. Antonetti DA, Barber AJ, Bronson SK, Freeman WM, Gardner TW, Jefferson LS, Kester M, Kimball SR, Krady JK, LaNoue KF, Norbury CC, Quinn PG, Sandirasegarane L, Simpson IA; JDRF Diabetic Retinopathy Center Group. Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes. 2006 Sep;55(9):2401-2411. https://doi.org/10.2337/db05-1635.PMID:16936187
  20. Adamis AP, Miller JW, Bernal MT, D’Amico DJ, Folkman J, Yeo TK, Yeo KT. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol. 1994;118(4): 445-450.  https://doi.org/10.1016/s0002-9394(14)75794-0
  21. Shishkin MM, Yuldasheva NM. Diabetic macular edema: modern views on pathogenesis and choice of treatment methods. Bulletin of the N.I. Pirogov National Medical and Surgical Center. 2012;7(1):122-127 (In Russ.).
  22. Ma T, Dong LJ, Du XL, Niu R, Hu BJ. Research progress on the role of connective tissue growth factor in fibrosis of diabetic retinopathy. Int J Ophthalmol. 2018;11(9):1550-1554. https://doi.org/10.18240/ijo.2018.09.20
  23. Kuiper EJ, Van Nieuwenhoven FA, de Smet MD, van Meurs JC, Tanck MW, Oliver N, Klaassen I, Van Noorden CJ, Goldschmeding R, Schlingemann RO. The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy. PLoS One. 2008;3(7):e2675. https://doi.org/10.1371/journal.pone.0002675
  24. Kuiper EJ, Hughes JM, Van Geest RJ, Vogels IM, Goldschmeding R, Van Noorden CJ, Schlingemann RO, Klaassen I. Effect of VEGF-A on expression of profibrotic growth factor and extracellular matrix genes in the retina. Invest Ophthalmol Vis Sci. 2007;48(9):4267-4276. https://doi.org/10.1167/iovs.06-0804
  25. He S, Jin ML, Worpel V, Hinton DR. A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. Arch Ophthalmol. 2003;121(9):1283-1288. https://doi.org/10.1001/archopht.121.9.1283
  26. Van Geest RJ, Leeuwis JW, Dendooven A, Pfister F, Bosch K, Hoeben KA, Vogels IM, Van der Giezen DM, Dietrich N, Hammes HP, Goldschmeding R, Klaassen I, Van Noorden CJ, Schlingemann RO. Connective tissue growth factor is involved in structural retinal vascular changes in long-term experimental diabetes. J Histochem Cytochem. 2014;62(2):109-118.  https://doi.org/10.1369/0022155413512656
  27. Simó R, Hernández C; European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR). Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives. Trends Endocrinol Metabolism. 2014;25(1):23-33.  https://doi.org/10.1016/j.tem.2013.09.005
  28. He X, Cheng R, Benyajati S, Ma JX. PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases. Clin Sci. 2015;128:805-823.  https://doi.org/10.1042/CS20130463
  29. Spranger J, Osterhoff M, Reimann M, Mohlig M, Ristow M, Francis MK, Cristofalo V, Hammes HP, Smith G, Boulton M, Pfeiffer AF. Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease. Diabetes. 2001;50:2641-2645. https://doi.org/10.2337/diabetes.50.12.2641
  30. Spandau U, Tomic Z. Small-Gauge Vitrectomy for Diabetic Retinopathy. 2nd ed. Switzerland (AG): Springer Cham; 2023. https://doi.org/10.1007/978-3-031-26204-3
  31. Yuldasheva NM, Kushalieva FA, Il’yasov ShSh. The role of the vitreous body in the development of proliferative diabetic retinopathy: from biochemistry to biomechanics. Zhurnal teoreticheskoi i klinicheskoi meditsiny. 2017;(5): 99-104 (In Russ.).
  32. Babaeva DB, Shishkin MM. Biomechanical impact of the vitreous in the pathophysiology of diabetic vitreopapillary traction syndrome. Sovremennye tekhnologii v oftal’mologii. 2020;1(32):103-106 (In Russ.). https://doi.org/10.25276/2312-4911-2020-2-103-106
  33. Stefánsson E. Physiology of vitreous surgery. Graefe’s Arch Clin Exper Ophthalmol. 2009;247(2):147-163.  https://doi.org/10.1007/s00417-008-0980-7
  34. Bezpal’chiĭ AN, Glinchuk IaI, Makhacheva ZA. Kislotno-shchelochnoe sostoyanie vnutriglaznykh sred u bol’nykh sakharnym diabetom. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 1986;102(5):59-61 (In Russ.).
  35. Konovalova KI, Shishkin MM, Fayzrakhmanov RR. Comparative analysis of the level of pro-inflammatory cytokines in tear of patients with advanced proliferative diabetic retinopathy and complicated primary cataract. Sovremennye tekhnologii v oftal’mologii. 2022;1(41):61-66 (In Russ.). https://doi.org/10.21516/2072-0076-2021-14-3-14-18
  36. Benson WE. Diabetes mellitus and the eye. In: Tasman W, Jaeger AE, eds. Duane’s Clinical Ophthalmology. Philadelphia, JB: Lippincott Co; 1990; 3(30):1-29.  https://doi.org/10.1179/acb.2004.034
  37. Chahed S, Leroyer AS, Benzerroug M, Gaucher D, Georgescu A, Picaud S, Silvestre JS, Gaudric A, Tedgui A, Massin P, Boulanger CM. Increased vitreous shedding of microparticles in proliferative diabetic retinopathy stimulates endothelial proliferation. Diabetes. 2010;59(3):694-701.  https://doi.org/10.2337/db08-1524
  38. Yoshida S, Ishikawa K, Matsumoto T, Yoshida A, Ishibashi T, Kono T. Reduced concentrations of angiogenesis-related factors in vitreous after vitrectomy in patients with proliferative diabetic retinopathy. Graefe’s Arch Clin Exper Ophthalmol. 2010;248(6):799-804.  https://doi.org/10.1007/s00417-010-1301-5
  39. Reva GV, Babich ME, Kiyanitsa NV. Features of the structure of the vitreous body in patients with diabetes mellitus. Fundamental’nye issledovaniya. 2006;(1):102 (In Russ.).
  40. Sdobnikova SV, Stolyarenko GE, Fedorov AA, Marchenko NR. On the role of the posterior hyaloid membrane in the pathogenesis and surgery of proliferative diabetic retinopathy. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 1996;112(4):5-7 (In Russ.).
  41. Ono R, Kakehashi A, Yamagami H, Sugi N, Kinoshita N, Saito T, Tamemoto H, Kuroki M, Lshikawa SE, Kawakami M. Prospective assessment of proliferative diabetic retinopathy with observations of posterior vitreous detachment. Int Ophthalmol. 2005;26:15-19.  https://doi.org/10.1007/s10792-005-5389-2
  42. Sultanov MI, Gadzhiev RV. Features of the course of diabetic retinopathy in myopia. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 1990;(1): 49-51 (In Russ.).
  43. Fayzrakhmanov RR, Pavlovskiy OA, Lukinykh MA. Morphofunctional parameters of diabetic macular edema after vitreoretinal surgery. Otrazhenie. 2024;1(17):46-50 (In Russ.). https://doi.org/10.25276/2686-6986-2024-1-46-50
  44. Petrachkov DV, Budzinskaya MV, Arzhukhanov DD. The role of internal limiting membrane peeling in the treatment of diabetic macular edema. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 2020;136(4):359-366 (In Russ.). https://doi.org/10.17116/oftalma2020136042359
  45. Babayeva DB, Shishkin MM, Fayzrakhmanov RR, Konovalova KI. Vitreopapillary traction syndrome in patients with proliferative diabetic retinopathy. Russian Annals of Ophthalmology=Vestnik oftal’mologii. 2021;137(6):38-44 (In Russ.). https://doi.org/10.17116/oftalma202113706138
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