Liver pathology in COVID-19

Krasnenkova S.F.; Zayratyants O.V.; Midiber K.Yu.; Mikhaleva L.M.

doi:https://doi.org/10.17116/patol20258701153

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Abstract:

The literature review presents an analysis of the pathogenesis and pathological anatomy of liver damage in COVID-19. Liver damage with the steatosis, vascular disorders, mild portal and lobular inflammatory infiltration, cholestasis and clinically — liver failure is observed in majority of the patients with COVID-19. Chronic liver diseases with infection SARS-CoV-2 tend to decompensate, which significantly worsens the prognosis of the disease. Pathogenesis of liver damage in COVID19 is unclear. There was no convincing evidence for the hypothesis of cytotoxicity for hepatocytes or cholangiocytes by SARS-CoV-2. Similar liver morphological changes described by different authors suggest their nonspecific nature and multifactorial pathogenesis related to hypoxia, cytokin storm, systemic inflammatory response syndrome, sepsis and shock, Covid-associated angio- and coagulopathy, as well as drug-induced hepatotoxicity. Further research is needed to clarify the pathogenesis and pathological anatomy of the liver pathology in COVID-19.

Keywords:

liver pathology

pathogenesis

pathological anatomy

COVID-19

Authors:

Krasnenkova S.F.

Russian University of Medicine;
Research Institute of Organization of Medicine and Medicine Management

ORCID: 0000-0002-4868-7804

Zayratyants O.V.

Russian University of Medicine;
Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

ORCID: 0000-0003-3606-3823

Midiber K.Yu.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery;
Peoples’ Friendship University of Russia named after Patrice Lumumba

ORCID: 0000-0002-1426-968X

Mikhaleva L.M.

A.P. Avtsyn Research Institute of Human Morphology Petrovsky National Research Center of Surgery;
Russian Medical Academy of Continuous Professional Education

ORCID: 0000-0003-2052-914X

Received:

13.07.2024

Accepted:

30.10.2024

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References:

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