The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Vasilev Y.I.

North-Western State Medical University named after I.I. Mechnikov

Grib P.A.

North-Western State Medical University named after I.I. Mechnikov

Karelov A.E.

North-Western State Medical University named after I.I. Mechnikov

Marova N.G.

North-Western State Medical University named after I.I. Mechnikov

Magnesium sulfate for prevention of postoperative pain syndrome

Authors:

Vasilev Y.I., Grib P.A., Karelov A.E., Marova N.G.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2022;(4): 71‑77

DOI: 10.17116/anaesthesiology202204171

Read: 8710 times

Download PDF (RU)
Contact the author
Table of contents

MAGNESIUM SULFATE FOR PREVENTION OF POSTOPERATIVE PAIN SYNDROME
MAGNESIUM SULFATE FOR PREVENTION OF POSTOPERATIVE PAIN SYNDROME

To cite this article:

Vasilev YI, Grib PA, Karelov AE, Marova NG. Magnesium sulfate for prevention of postoperative pain syndrome. Russian Journal of Anesthesiology and Reanimatology. 2022;(4):71‑77. (In Russ.)
https://doi.org/10.17116/anaesthesiology202204171

МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Asse­ssment of the quality of life of patients after dental surgeries using kine­siotaping and infrared laser therapy. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(6-2):110-116
Possibilities of using meldonium as part of complex therapy in patients with ischemic heart disease and chro­nic heart failure combined with obesity. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(1):53-60
Clinical effi­cacy of high-intensity magnetic therapy and transcutaneous electrical nerve stimulation in patients with diabetes mellitus and distal poly­neuropathy: a randomized study. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2025;(1):5-11
Effi­cacy and safety of mome­tasone and olopatadine combination for nasal use in patients with alle­rgic rhinitis caused by sensitization to epidermal alle­rgens in continuous expo­sure. Russian Rhinology. 2025;(1):48-56
Treatment of acute hemo­rrhoids acco­rding to the resu­lts of a multicenter obse­rvational study. Piro­gov Russian Journal of Surgery. 2025;(3):112-123
Vali­dation of the Russian version of the Caro­linas Comfort Scale in patients after previous abdo­minal hernia repair with mesh. Piro­gov Russian Journal of Surgery. 2025;(4):30-30
Prediction and prevention of burnout syndrome in health care professionals in high epidemic risk settings. Russian Journal of Preventive Medi­cine. 2025;(4):51-56
The effect of a gami­fication on healthy indi­viduals’ motor acti­vity. Russian Journal of Preventive Medi­cine. 2025;(4):111-116
Analysis of the oral health-related quality of life among school children and young adults before and after orthodontic treatment. Stomatology. 2025;(2):54-58
Late complications and quality of life after multivisceral surgeries with pancreatoduodenectomy. Piro­gov Russian Journal of Surgery. 2025;(7):36-45
Abstract:

Background. Neuropathic pain is the main component of chronic postoperative pain syndrome. The use of magnesium sulfate for prevention of pain syndrome is theoretically based on its ability to N-methyl-D-aspartate receptors block in the spinal cord.

OBJECTIVE

To assess the effect of magnesium sulfate as an adjuvant analgesic for prevention of postoperative and chronic pain syndrome after surgery under combined anesthesia.

MATERIAL AND METHODS

The study included 112 patients randomized into 2 groups: magnesium sulfate infusion (n=37) and saline infusion (n=75). On the first postoperative day, ketorolac 30 mg was prescribed in all patients. After 2—3 days, pain relief was carried out at patient request. We analyzed pain severity on the first and the third postoperative days using the Brief Pain Inventory. After 3, 6 and 12 months, the Mac Gill pain questionnaire was used for two indicators (index of the number of selected descriptors and general rank index). Statistical analysis was performed using the Past 4.0 software (Sytel Studio). Wilcoxon criterion was used for pairwise comparisons of pain index, Fisher’s and Mann-Whitney tests — for analysis of Mac Gill scores.

RESULTS

For most categories, we found no significant between-group difference except for evaluative category in 3 months after surgery. In the main group, patients felt less effect of mild pain syndrome, and none had severe pain. At the same time, between-group difference of this indicator was significant (p=0.022).

CONCLUSION

The use of magnesium sulfate ensures higher quality of life in 3 months after surgery compared to the control group.

Keywords:

chronic postoperative pain syndrome
pain after surgery
adjuvant analgesics
magnesia sulfate
quality of life
Brief pain inventory
McGill pain questionnaire

Authors:

Vasilev Y.I.

North-Western State Medical University named after I.I. Mechnikov

Grib P.A.

North-Western State Medical University named after I.I. Mechnikov

Karelov A.E.

North-Western State Medical University named after I.I. Mechnikov

Marova N.G.

North-Western State Medical University named after I.I. Mechnikov

Received:

08.06.2021

Accepted:

16.02.2022

Close metadata

References:

  1. Medvedeva LA, Zagorul’ko OI, Belov YuV. Chronic post-operative pain: current state of evidence and prevention. Anesteziologiya i reanimatologiya. 2017;62(4):305-309. (In Russ.).
  2. Haroutiunian S, Nikolajsen L, Finnerup NB, Jensen TS. The neuropathic component in persistent postsurgical pain: a systematic literature review. Pain. 2013;154(1):95-102.  https://doi.org/10.1016/j.pain.2012.09.010
  3. Ovechkin AM. Chronic postoperative pain syndrome — «a pitfall» of modern surgery. Regionarnaya anesteziya i lechenie ostroy boli. 2016;10(1):5-18. (In Russ.).
  4. Efremenko IV, Ovechkin AM, Krasnoselskiy MYa. The analysis of effectiveness of isolated and combined prescription of non-opioid analgesics and adjutants during different surgery. Regionarnaya anesteziya i lechenie ostroy boli. 2015;9(3):19-28. (In Russ.).
  5. Efremenko IV, Ovechkin AM. Modern possibilities of non-opioid postoperative pain relief. Hirurgičeskaâ praktika. 2013;1:36-43. (In Russ.).
  6. Turk DC, Dworkin RH, McDermott MP, Bellamy N, Burke LB, Chandler JM, Cleeland CS, Cowan P, Dimitrova R, Farrar JT, Hertz S, Heyse JF, Iyengar S, Jadad AR, Jay GW, Jermano JA, Katz NP, Manning DC, Martin S, Max MB, McGrath P, McQuay HJ, Quessy S, Rappaport BA, Revicki DA, Rothman M, Stauffer JW, Svensson O, White RE, Witter J. Analyzing multiple endpoints in clinical trials of pain treatments: IMMPACT recommendations. Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials. Pain. 2008;139(3):485-493.  https://doi.org/10.1016/j.pain.2008.06.025
  7. Turk DC, Dworkin RH, Allen RR, Bellamy N, Brandenburg N, Carr DB, Cleeland C, Dionne R, Farrar JT, Galer BS, Hewitt DJ, Jadad AR, Katz NP, Kramer LD, Manning DC, McCormick CG, McDermott MP, McGrath P, Quessy S, Rappaport BA, Robinson JP, Royal MA, Simon L, Stauffer JW, Stein W, Tollett J, Witter J. Core outcome domains for chronic pain clinical trials: IMMPACT recommendations. Pain. 2003;106(3):337-345.  https://doi.org/10.1016/j.pain.2003.08.001
  8. Taylor AM, Phillips K, Patel KV, Turk DC, Dworkin RH, Beaton D, Clauw DJ, Gignac MAM, Markman JD, Williams DA, Bujanover S, Burke LB, Carr DB, Choy EH, Conaghan PG, Cowan P, Farrar JT, Freeman R, Gewandter J, Gilron I, Goli V, Gover TD, Haddox JD, Kerns RD, Kopecky EA, Lee DA, Malamut R, Mease P, Rappaport BA, Simon LS, Singh JA, Smith SM, Strand V, Tugwell P, Vanhove GF, Veasley C, Walco GA, Wasan AD, Witter J. Assessment of physical function and participation in chronic pain clinical trials: IMMPACT/OMERACT recommendations. Pain. 2016;157(9):1836-1850. https://doi.org/10.1097/j.pain.0000000000000577
  9. Ovechkin AM, Efremenko IV. Perioperation analgesia: role of medications that influence NMDS-receptor complex. Rossijskij zhurnal boli. 2011;30(1):31-37. (In Russ.).
  10. Morozov AM, Sergeev AN, Kadykov VA, Zhukov SV, Minakova YuE, Pichugova AN, Belyak MA. Chronic pain syndrome, risk factors for its development at stage of operative intervention. Sibirskoe medicinskoe obozrenie. 2021;131(5):5-13. (In Russ.). https://doi.org/10.20333/25000136-2021-5-5-13
  11. Ovechkin AM, Efremenko IV. Pharmacotherapy for acute postoperative pain based on use of NMDA-associated drugs. Anesteziologiya i reanimatologiya. 2013;3:63-69. (In Russ.).
  12. Ovechkin AM, Efremenko IV, Krasnoselsky MYa. Postoperative analgesia based on the complex use of non-opioid analgesics and drugs affecting NMDA receptors. Rossijskij zhurnal boli. 2015;40(3-4):34-40. (In Russ.).
  13. Fields HL, Rowbotham M, Baron R. Postherpetic neuralgia: irritable nociceptors and deafferentation. Neurobiology of Disease. 1998;5(4):209-227.  https://doi.org/10.1006/nbdi.1998.0204
  14. Kvarnström A, Karlsten R, Quiding H, Emanuelsson BM, Gordh T. The effectiveness of intravenous ketamine and lidocaine on peripheral neuropathic pain. Acta Anaesthesiologica Scandinavica. 2003;47(7):868-877.  https://doi.org/10.1034/j.1399-6576.2003.00187.x
  15. Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. The Journal of Pain. 2009;10(9):895-926.  https://doi.org/10.1016/j.jpain.2009.06.012
  16. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152(3 suppl):2-15.  https://doi.org/10.1016/j.pain.2010.09.030
  17. Albrecht E, Kirkham KR, Liu SS, Brull R. Peri-operative intravenous administration of magnesium sulphate and postoperative pain: a meta-analysis. Anaesthesia. 2013;68(1):79-90.  https://doi.org/10.1111/j.1365-2044.2012.07335.x
  18. McCarthy RJ, Kroin JS, Tuman KJ, Penn RD, Ivankovich AD. Antinociceptive potentiation and attenuation of tolerance by intrathecal co-infusion of magnesium sulfate and morphine in rats. Anesthesia and Analgesia. 1998;86(4):830-836.  https://doi.org/10.1097/00000539-199804000-00028
  19. Weissberg N, Schwartz G, Shemesh O, Brooks BA, Algur N, Eylath U, Abraham AS. Serum and intracellular electrolytes in patients with and without pain. Magnesium Research. 1991;4(1):49-52. 
  20. James MFM. Magnesium an emerging drug in anesthesia. British Journal of Anaesthesia. 2009;103(4):465-467.  https://doi.org/10.1093/bja/aep242
  21. Guo BL, Lin Y, Hu W, Zhen CX, Bao-Cheng Z, Wu HH, Kaye AD, Duan JH, Qu Y. Effects of systemic magnesium on post-operative analgesia: is the current evidence strong enough? Pain Physician. 2015;18(5):405-418. 
  22. De Oliveira GS Jr, Castro-Alves LJ, Khan JH, McCarthy RJ. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials. Anesthesiology. 2013;119(1):178-190.  https://doi.org/10.1097/ALN.0b013e318297630d
  23. Murphy JD, Paskaradevan J, Eisler LL, Ouanes JP, Tomas VA, Freck EA, Wu CL. Analgesic efficacy of continuous intravenous magnesium infusion as an adjuvant to morphine for postoperative analgesia: a systematic review and meta-analysis. Middle East Journal of Anaesthesiology. 2013;22(1):11-20. 
  24. Choi H, Parmar N. The use of intravenous magnesium sulphatefor acute migraine: meta-analysis of randomized controlled trials. European Journal of Emergency Medicine. 2014;21(1):2-9.  https://doi.org/10.1097/MEJ.0b013e3283646e1b
  25. Chiu HY, Yeh TH, Huang YC, Chen PY. Effects of intravenous and oral magnesium on reducing migraine: a meta-analysis of randomized controlled trials. Pain Physician. 2016;19(1):97-112. 
  26. Fischer SG, Collins S, Boogaard S, Loer SA, Zuurmond WW, Perez RS. Intravenous magnesium for chronic complex regional pain syndrome type 1 (CRPS-1). Pain Medicine. 2013;14(9):1388-1399. https://doi.org/10.1111/pme.12211
  27. Pickering G, Morel V, Simen E, Cardot JM, Moustafa F, Delage N, Picard P, Eschalier S, Boulliau S, Dubray C. Oral magnesium treatment in patients with neuropathicpain: a randomized clinical trial. Magnesium Research. 2011;24(2):28-35.  https://doi.org/10.1684/mrh.2011.0282
  28. Brill S, Sedgwick PM, Hamann W, Di Vadi PP. Efficacy of intravenous magnesium in neuropathic pain. British Journal of Anaesthesia. 2002;89(5):711-714. 
  29. Kim YH, Lee PB, Oh TK. Is magnesium sulfate efective forpain in chronic postherpetic neuralgia patients comparing withketamine infusion therapy? Journal of Clinical Anesthesia. 2015;27(4):296-300.  https://doi.org/10.1016/j.jclinane.2015.02.006
  30. Oh TK, Chung SH, Park J, Shin H, Chang CB, Kim TK, Do SH. Effects of Perioperative Magnesium Sulfate Administration on Postoperative Chronic Knee Pain in Patients Undergoing Total Knee Arthroplasty: A Retrospective Evaluation. Journal of Clinical Medicine. 2019;8(12):2231. https://doi.org/10.3390/jcm8122231
  31. Ghezel-Ahmadi V, Ghezel-Ahmadi D, Schirren J, Tsapopiorgas C, Beck G, Bölükbas S. Perioperative systemic magnesium sulphate to minimize acute and chronic post-thoracotomy pain: a prospective observational study Journal of Thoracic Disease. 2019;11(2):418-426.  https://doi.org/10.21037/jtd.2019.01.50
  32. Kamel EZ, Abd-Elshafy SK, Sayed JA, Mostafa MM, Seddik MI. Pain alleviation in patients undergoing cardiac surgery; presternal local anesthetic and magnesium infiltration versus conventional intravenous analgesia: a randomized double-blind study. The Korean Journal of Pain. 2018;31(2):93-101.  https://doi.org/10.3344/kjp.2018.31.2.93
  33. Bardgett ME, Schultheis PJ, McGill DL, Richmond RE, Wagge JR. Magnesium deficiency impairs fear conditioning in mice. Brain Research. 2005;1038(1):100-106.  https://doi.org/10.1016/j.brainres.2005.01.020
  34. Bhatia A, Kashyap L, Pawar DK, Trikha A. Effect of intraoperative magnesium infusion on perioperative analgesia in open cholecystectomy. Journal of Clinical Anesthesia. 2004;16(4):262-265.  https://doi.org/10.1016/j.jclinane.2003.08.012
  35. Srebro D, Vuckovic S, Milovanovic A, Kosutic J, Vujovic KS, Prostran M. Magnesium in pain research: state of the art. Current Medicinal Chemistry. 2017;24(4):424-434.  https://doi.org/10.2174/0929867323666161213101744
  36. Mercieri M, De Blasi RA, Palmisani S, Forte S, Cardelli P, Romano R, Pinto G, Arcioni R. Changes in cerebrospinal fluid magnesium levels in patients undergoing spinal anaesthesia for hip arthroplasty: Does intravenous infusion of magnesium sulphate make any difference? Prospective, randomized, controlled study. British Journal of Anaesthesia. 2012;109(2):208-215.  https://doi.org/10.1093/bja/aes146
  37. Lee JH, Yang WD, Han SY, Noh JI, Cho SH, Kim SH, Chae WS, Jin HC. Effect of epidural magnesium on the incidence of chronic postoperative pain after video-assisted thoracic surgery. Journal of Cardiothoracic and Vascular Anesthesia. 2012;26(6):1055-1059. https://doi.org/10.1053/j.jvca.2012.06.020
  38. Pockett S. Spinal cord synaptic plasticity and chronic pain. Anesthesia and Analgesia. 1995;80(1):173-179.  https://doi.org/10.1097/00000539-199501000-00026
  39. Koinig H, Wallner T, Marhofer P, Andel H, Hörauf K, Mayer N. Magnesium sulfate reduces intra- and postoperative analgesic requirements. Anesthesia and Analgesia. 1998;87(1):206-210.  https://doi.org/10.1097/00000539-199807000-00042
  40. Lipnitski AL. Safety of magnesium sulphate introduction as adjuvant before general anesthesia. Anesteziologiya i reanimatologiya. 2015;60(4S):78. (In Russ.).
  • Palmer BF, Clegg DJ. Electrolyte Disturbances in Chronic Alcohol-Use Disorder. N Engl J Med. 2018;378(2):203-204.  https://doi.org/10.1056/NEJMc1714331
  • Broeren MA, Geerdink EA, Vader HL, van den Wall Bake AW. Hypomagnesemia induced by several proton-pump inhibitors [published correction appears in Ann Intern Med. 2010;152(4):268]. Ann Intern Med. 2009;151(10):755-756.  https://doi.org/10.7326/0003-4819-151-10-200911170-00016
  • Park CH, Kim EH, Roh YH, Kim HY, Lee SK. The association between the use of proton pump inhibitors and the risk of hypomagnesemia: a systematic review and meta-analysis. PLoS One. 2014;9(11):e112558. Published 2014 Nov 13.  https://doi.org/10.1371/journal.pone.0112558
  • Cheungpasitporn W, Thongprayoon C, Kittanamongkolchai W, et al. Proton pump inhibitors linked to hypomagnesemia: a systematic review and meta-analysis of observational studies. Ren Fail. 2015;37(7):1237-1241. https://doi.org/10.3109/0886022X.2015.1057800
  • FDA drug safety communication: low magnesium levels can be associated with long-term use of Proton Pump Inhibitor drugs (PPIs). Silver Spring, MD: Food and Drug Administration, March 2, 2011. https://www.fda.gov/drugs/drugsafety/ucm245011.htm
  • Palmer BF. Diagnostic approach and management of inpatient hyponatremia. J Hosp Med. 2010;5(suppl 3):1-7.  https://doi.org/10.1002/jhm.702
  • Achinger SG, Ayus JC. Electrolyte Disturbances in Chronic Alcohol-Use Disorder. N Engl J Med. 2018;378(2):202-203.  https://doi.org/10.1056/NEJMc1714331
  • Sterns RH, Silver SM. Complications and management of hyponatremia. Curr Opin Nephrol Hypertens. 2016;25(2):114-119.  https://doi.org/10.1097/MNH.0000000000000200
  • Sanghvi SR, Kellerman PS, Nanovic L. Beer potomania: an unusual cause of hyponatremia at high risk of complications from rapid correction. Am J Kidney Dis. 2007;50(4):673-680.  https://doi.org/10.1053/j.ajkd.2007.07.015
  • Bähr M, Sommer N, Petersen D, Wiethölter H, Dichgans J. Central pontine myelinolysis associated with low potassium levels in alcoholism. J Neurol. 1990;237(4):275-276.  https://doi.org/10.1007/BF00314635
  • Falcone N, Compagnoni A, Meschini C, Perrone C, Nappo A. Central pontine myelinolysis induced by hypophosphatemia following Wernicke’s encephalopathy. Neurol Sci. 2004;24(6):407-410.  https://doi.org/10.1007/s10072-003-0197-9
  • Ayus JC, Armstrong D, Arieff AI. Hyponatremia with hypoxia: effects on brain adaptation, perfusion, and histology in rodents. Kidney Int. 2006;69(8):1319-1325. https://doi.org/10.1038/sj.ki.5000187
  • Sterns RH. Disorders of plasma sodium--causes, consequences, and correction. N Engl J Med. 2015;372(1):55-65.  https://doi.org/10.1056/NEJMra1404489
    • Contact the author
    Email
    Message
    The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

    Email Confirmation

    An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

    Email Confirmation

    Contact us
    If you have any questions, complaints or suggestions, please use this feedback form.
    Email
    Message
    The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
    Submit Application

    You can become an author of one of our magazines, send a request and we will consider it in during the day.

    Name
    Phone
    E-mail
    Message
    Login
    Registration
    E-mail
    Password
    Forgot Password?

    Log in to the site using your account in one of the services

    Password recovery
    E-mail
    Login
    Register

    We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.