The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Bobrova O.P.

Voino-Yasenetsky Krasnoyarsk State Medical University;
Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Center

Shnayder N.A.

Bekhterev National Medical Research Center of Psychiatry and Neurology

Petrova M.M.

Voino-Yasenetsky Krasnoyarsk State Medical University

Dykhno Yu.A.

Voino-Yasenetsky Krasnoyarsk State Medical University;
Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Center

Zyryanov S.K.

Peoples’ Friendship University of Russia (RUDN University)

Bobrov A.V.

Reshetnev Siberian State University of Science and Technology

Nasyrova R.F.

Bekhterev National Medical Research Center of Psychiatry and Neurology

Lipinsky L.V.

Reshetnev Siberian State University of Science and Technology

Polyakova A.S.

Reshetnev Siberian State University of Science and Technology

Melnikova O.D.

Reshetnev Siberian State University of Science and Technology

Personalized modeling of opioid-associated constipation in patients with pancreatic cancer

Authors:

Bobrova O.P., Shnayder N.A., Petrova M.M., Dykhno Yu.A., Zyryanov S.K., Bobrov A.V., Nasyrova R.F., Lipinsky L.V., Polyakova A.S., Melnikova O.D.

More about the authors

Journal: Russian Journal of Pain. 2020;18(4): 31‑39

DOI: 10.17116/pain20201804131

Read: 1057 times

Download PDF (RU)
Contact the author
Table of contents

PERSONALIZED MODELING OF OPIOID-ASSOCIATED CONSTIPATION IN PATIENTS WITH PANCREATIC CANCER
PERSONALIZED MODELING OF OPIOID-ASSOCIATED CONSTIPATION IN PATIENTS WITH PANCREATIC CANCER

To cite this article:

Bobrova OP, Shnayder NA, Petrova MM, et al. . Personalized modeling of opioid-associated constipation in patients with pancreatic cancer. Russian Journal of Pain. 2020;18(4):31‑39. (In Russ.)
https://doi.org/10.17116/pain20201804131

Подписка 2025 Российский журнал боли (Russian Journal of Pain)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Portal homo­graft in pancreatic head cancer surgery: first expe­rience. P.A. Herzen Journal of Onco­logy. 2025;(1):42-47
Mode­ling and predicting chro­nic non-communicable diseases based on medi­cal and social risk factors in older then working age people. Russian Journal of Preventive Medi­cine. 2025;(4):67-74
Novel opioids in postoperative pain mana­gement. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):78-84
Use of HIFU therapy in combination with mono­chemotherapy in a patient with loca­lly adva­nced adenogenic pancreatic cancer and impaired functional status. P.A. Herzen Journal of Onco­logy. 2025;(3):83-88
Infu­sion therapy and acinar component of the pancreas as predictors of pancreatic fistula in pancreatoduodenectomy. Russian Journal of Anesthesiology and Reanimatology. 2025;(5):58-65
Beautiful rela­tionship between art and medi­cine: from clay mode­ling to auri­cular cartilage mode­ling. Plastic Surgery and Aesthetic Medi­cine. 2025;(3-2):71-77
Stra­tegy for early diagnosis and prevention of pancreatic cancer. Russian Journal of Evidence-Based Gastroenterology. 2025;(4):86-93
Neoadjuvant chemotherapy for rescectable pancreatic cancer: “fashion” or nece­ssity?. Piro­gov Russian Journal of Surgery. 2026;(1):85-90
Abstract:

OBJECTIVE

To develop a risk scale for predicting the opioid-associated constipation in patients with pancreatic cancer.

MATERIAL AND METHODS

There were 45 patients with verified pancreatic cancer aged 18—75 years. We have studied 57 predictors of opioid-associated constipation in patients with pancreatic cancer receiving morphine sulfate orally.

RESULTS

Eight the most significant prognostic factors of morphine-associated constipation were identified. We have developed the prognostic model for morphine-associated constipation in patients with pancreatic cancer. Moreover, the prognostic scale has been created for stratifying the risk of morphine-associated constipation in patients with pancreatic cancer.

CONCLUSION

Analysis of risk of morphine-associated constipation is valuable in patients with pancreatic cancer for personalized opioid therapy.

Keywords:

morphine sulfate
modeling
risk scale
constipation
pancreatic cancer

Authors:

Bobrova O.P.

Voino-Yasenetsky Krasnoyarsk State Medical University;
Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Center

Shnayder N.A.

Bekhterev National Medical Research Center of Psychiatry and Neurology

Petrova M.M.

Voino-Yasenetsky Krasnoyarsk State Medical University

Dykhno Yu.A.

Voino-Yasenetsky Krasnoyarsk State Medical University;
Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Center

Zyryanov S.K.

Peoples’ Friendship University of Russia (RUDN University)

Bobrov A.V.

Reshetnev Siberian State University of Science and Technology

Nasyrova R.F.

Bekhterev National Medical Research Center of Psychiatry and Neurology

Lipinsky L.V.

Reshetnev Siberian State University of Science and Technology

Polyakova A.S.

Reshetnev Siberian State University of Science and Technology

Melnikova O.D.

Reshetnev Siberian State University of Science and Technology

Received:

14.07.2020

Accepted:

02.09.2020

Close metadata

References:

  1. Alatab S, Sepanlou SG, Ikuta KS, et al. The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2019;S2468-1253(19):30333-30334. https://doi.org/10.1016/S2468-1253(19)30333-4
  2. De Gregori S, Minella CE, De Gregori M, et al. Clinical pharmacokinetics of morphine and its metabolites during morphine dose titration for chronic cancer pain. Ther Drug Monit. 2014;36:335-344.  https://doi.org/10.1097/FTD.0000000000000009
  3. Bobrova OP, Zukov RA, Modestov AA. Puti optimizatsii farmakonutritivnoi podderzhki v operativnoi onkologii. Sibirskoe meditsinskoe obozrenie. 2015;5:76-79. (In Russ.).
  4. Vieira CMP, Fragoso RM, Pereira D, Medeiros R. Pain polymorphisms and opioids: An evidence based review. Mol Med Rep. 2019;19(3):1423-1434. https://doi.org/10.3892/mmr.2018.9792
  5. Schug SA, Chandrasena C: Pain management of the cancer patient. Expert Opin Pharmacother. 2015;16:5-15.  https://doi.org/10.1517/14656566.2015.980723
  6. Chernova AA, Nikulina SYu, Plita EV, Marilovtseva OV, Kuskaeva AV. Analiticheskij programmnyj kompleks «Geneticheskij riskometr narushenij serdechnogo ritma i provodmosti». Sibirskoe meditsinskoe obozrenie. 2015;6:108-111. (In Russ.).
  7. Sobin LKh, Gospodarovich MK, Vittekind K. TNM. Klassifikatsiya zlokachestvennykh opukholej. Logosfera; 2011. (In Russ.).
  8. Abuzarova GR, Sarmanaeva RR, Lapina SE, et al. Sil’nye opioidnye anal’getiki v terapii khronicheskogo bolevogo sindroma. Kakoj preparat predpochest’? Onkologiya. Zhurnal im. P.A. Gertsena. 2017;6(6):62-71. (In Russ.). https://doi.org/10.17116/onkolog20176662-71
  9. Kumar L, Barker C, Emmanuel A. Opioid-induced constipation: pathophysiology, clinical consequences, and management. Gastroenterol Res Pract. 2014;2014:141737. https://doi.org/10.1155/2014/141737
  10. Prichard D, Norton C, Bharucha AE. Management of opioid-induced constipation. Br J Nurs. 2016;25(10):4-11.  https://doi.org/10.12968/bjon.2016.25.10.S4
  11. Müller-Lissner S, Bassotti G, Coffin B, et al. Opioid-Induced Constipation and Bowel Dysfunction: A Clinical Guideline. Pain Med. 2017;18(10):1837-1863. https://doi.org/10.1093/pm/pnw255
  12. Farmer AD, Holt CB, Downes TJ, et al. Pathophysiology, diagnosis, and management of opioid-induced constipation. Lancet Gastroenterol Hepatol. 2018;3(3):203-212.  https://doi.org/10.1016/S2468-1253(18)30008-6
  13. Kraichely RE, Arora AS, Murray JA, et al. Opiate-induced oesophagealdysmotility. Aliment Pharmacol Ther. 2010;31(5):601-606.  https://doi.org/10.1111/j.1365-2036.2009.04212.x
  14. Brock C, Olesen SS, Olesen AE. Opioid-induced bowel dysfunction: pathophysiology and management. Drugs. 2012;72(14):1847-1865. https://doi.org/10.2165/11634970-000000000-00000
  15. Bobrova OP, Shnayder NA, Petrova MM, Gavrilyuk OA. Genetic polymorphism of cytokines as a predictor of phenotypic development of chronic pain syndrome in cancer patients. International Journal of Business and Management. 2017;4(7):277-281.  https://doi.org/10.21103/Article7(4)_RA1
  16. Bobrova OP, Schnaider NA, Zyryanov SK, et al. Vliyanie polimorfizma genov OPRM1, ABCB1, IL1B, PTGS2, LOC51472 na variabel’nost’ khronicheskogo bolevogo sindroma u patsientov s rakom podzheludochnoj zhelezy. Kachestvennaya klinicheskaya praktika. 2019;3:53-59 (In Russ.).
  17. Kesimci E, Engin AB, Kanbak O, Karahalil B. Association between ABCB1 gene polymorphisms and fentanyl’s adverse effects in Turkish patients undergoing spinal anesthesia. Gene. 2012;493(2):273-277.  https://doi.org/10.1016/j.gene.2011.11.040
  18. Ding Z, Yang L, Xie X, et al. Expression and significance of hypoxiainducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells. Cancer Res Clin Oncol. 2010;3:1276-1282. https://doi.org/10.1007/s00432-010-0828-5
  19. Zhang W, Chang YZ, Kan QC, et al. Association of human μ-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients. Anaesthesia. 2010;65:130-135.  https://doi.org/10.1111/j.1365-2044.2009.06193.x
  20. Jones JD, Luba RR, Vogelman JL, et al. Searching for Evidence of Genetic Mediation of Opioid Withdrawal by opioid receptor gene polymorphisms. The American Journal on Addictions. 2016;25:41-48.  https://doi.org/10.1111/ajad.12316
  21. Neeb L, Hellen P, Boehnke C, et al. IL-1beta stimulates COX-2 dependent PGE synthesis and CGRP release in rat trigeminal ganglia cells. PLoS One. 2011;6(3):e17360. https://doi.org/10.1371/journal.pone.0017360
  22. Muraoka W, Nishizawa D, Fukuda K, et al. Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery. Mol Pain. 2016;12:1744806916683182. https://doi.org/10.1177/1744806916683182
  23. De Gregori S, De Gregori M, Ranzani GN, et al. Morphine metabolism, transport and brain disposition. Metab Brain Dis. 2012;27(1):1-5.  https://doi.org/10.1007/s11011-011-9274-6
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.