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Vlasenko O.S.

Blokhin National Cancer Research Center

Polyakov A.N.

Blokhin National Medical Research Center of Oncology

Matveeva S.O.

Blokhin National Cancer Research Center

Kudashkin N.E.

Blokhin National Medical Cancer Research Center

Egenov O.A.

Blokhin National Medical Cancer Research Center

Salkova V.Yu.

Blokhin National Cancer Research Center

Podluzhnyi D.V.

Blokhin National Medical Cancer Research Center

Sytov A.V.

Blokhin National Cancer Research Center

Infusion therapy and acinar component of the pancreas as predictors of pancreatic fistula in pancreatoduodenectomy

Authors:

Vlasenko O.S., Polyakov A.N., Matveeva S.O., Kudashkin N.E., Egenov O.A., Salkova V.Yu., Podluzhnyi D.V., Sytov A.V.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2025;(5): 58‑65

DOI: 10.17116/anaesthesiology202505158

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Table of contents

INFUSION THERAPY AND ACINAR COMPONENT OF THE PANCREAS AS PREDICTORS OF PANCREATIC FISTULA IN PANCREATODUODENECTOMY
INFUSION THERAPY AND ACINAR COMPONENT OF THE PANCREAS AS PREDICTORS OF PANCREATIC FISTULA IN PANCREATODUODENECTOMY

To cite this article:

Vlasenko OS, Polyakov AN, Matveeva SO, et al. . Infusion therapy and acinar component of the pancreas as predictors of pancreatic fistula in pancreatoduodenectomy. Russian Journal of Anesthesiology and Reanimatology. 2025;(5):58‑65. (In Russ.)
https://doi.org/10.17116/anaesthesiology202505158

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Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the effect of first-day infusion and pancreatic acinar structures on the incidence of postoperative pancreatic fistulas (POPF) and complications after pancreatoduodenectomy.

MATERIAL AND METHODS

A retrospective study included patients who underwent pancreatoduodenectomy in 2024.

RESULTS

There were 79 patients: group 1 (n=38) — infusion ≥4.5 ml/kg/h on day 1, group 2 (n=41) — infusion <4.5 ml/kg/h. The median of acinar structures was 65%. POPF were found in 23.6% (n=9) and 53.6% (n= 22) of patients, respectively (p=0.021). POPF type B prevailed (21.0% (n=8) and 51.2% (n=21) of patients, respectively, p=0.033). Clavien-Dindo grade III—V complications occurred in 26.3% (n=10) and 58.5% (n=24) of patients, respectively (p=0.022). Multifactorial analysis showed that daily infusion <4.5 ml/kg/h (OR=3.938; 95% CI 1.461—10.614; p=0.025) and acinar structures ≥65% (OR=12.889; 95% CI 4.285—38.772; p=0.001) were predictors of type B POPF. Acinar structures ≥65% were predictors of Clavien-Dindo grade ≥III complications (OR=11.487; 95% CI 3.853—34.243; p=0.003).

CONCLUSION

Daily infusion <4.5 ml/kg/h (p=0.025) and acinar structures ≥65% (p=0.001) increase the incidence of type B POPF after pancreatoduodenectomy. Acinar structures ≥65% increase the incidence of Clavien-Dindo ≥ grade III complications (p=0.003).

Keywords:

pancreatic cancer
pancreatic resection
acinar structures of the pancreas
postoperative complications

Authors:

Vlasenko O.S.

Blokhin National Cancer Research Center

Polyakov A.N.

Blokhin National Medical Research Center of Oncology

Matveeva S.O.

Blokhin National Cancer Research Center

Kudashkin N.E.

Blokhin National Medical Cancer Research Center

Egenov O.A.

Blokhin National Medical Cancer Research Center

Salkova V.Yu.

Blokhin National Cancer Research Center

Podluzhnyi D.V.

Blokhin National Medical Cancer Research Center

Sytov A.V.

Blokhin National Cancer Research Center

Received:

14.01.2025

Accepted:

12.05.2025

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