Strategy for early diagnosis and prevention of pancreatic cancer

Osadchuk A.M.; Osadchuk M.A.; Loranskaya I.D.

doi:https://doi.org/10.17116/dokgastro20251404186

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OBJECTIVE

To summarize current perspectives on the early diagnosis and prevention of pancreatic cancer.

KEY POINTS

Early detection is essential primarily in high-risk populations, including individuals with genetic predisposition and those with a personal history of pancreatic neoplasia. In these high-risk groups, screening programs should incorporate regularly scheduled imaging—primarily magnetic resonance imaging — with or without the use of biomarkers such as CA 19-9. Currently, there is insufficient evidence to support population-wide screening due to the lack of cost-effective tests. Preventive strategies include lifestyle and wellness interventions, general cancer screening, mental health improvement, and the targeted use of digital biomarkers. Chemoprevention approaches for high-risk individuals are discussed, with evidence suggesting a reduced likelihood of PC development in diabetic patients receiving metformin or aspirin.

CONCLUSION

Despite recent progress, the majority of pancreatic cancer cases continue to be diagnosed at advanced stages. Early detection and prompt treatment remain the most effective means of improving outcomes. A comprehensive diagnostic approach that integrates laboratory, imaging, and histopathological data with artificial intelligence-based tools holds promise for facilitating earlier disease identification.

Keywords:

pancreatic cancer

early detection

prevention

epidemiology

risk factors

Authors:

Osadchuk A.M.

Russian Medical Academy of Continuous Professional Education Ministry of Health of the Russian Federation

ORCID: 0000-0002-8488-9235

Osadchuk M.A.

Sechenov First Moscow State Medical University (Sechenov University) Ministry of Health of the Russian Federation

SPIN RSCI: 3108-0478
Scopus AuthorID: 6701741609
ORCID: 0000-0003-0485-6802

Loranskaya I.D.

Russian Medical Academy of Continuous Professional Education Ministry of Health of the Russian Federation

ORCID: 0000-0002-3681-4132

Received:

26.02.2025

Accepted:

14.05.2025

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References:

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