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Belyashova A.S.
Burdenko Neurosurgical Center
Galkin M.V.
Burdenko National Medical Research Center for Neurosurgery
Antipina N.A.
Burdenko Neurosurgical Center
Pavlova G.V.
Burdenko National Medical Research Center of Neurosurgery
Golanov A.V.
Burdenko Neurosurgical Center
Cell cultures in assessing radioresistance of glioblastomas
Journal: Burdenko's Journal of Neurosurgery. 2022;86(5): 126‑132
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To cite this article:
Belyashova AS, Galkin MV, Antipina NA, Pavlova GV, Golanov AV. Cell cultures in assessing radioresistance of glioblastomas. Burdenko's Journal of Neurosurgery.
2022;86(5):126‑132. (In Russ., In Engl.)
https://doi.org/10.17116/neiro202286051126
To date, no modern methods of treatment allow overcoming malignant potential of glial neoplasms and significant increase of survival. Analysis of glioblastoma radioresistance using cancer cell cultures is one of the perspective directions, as radiotherapy is standard and available treatment method for these neoplasms. This review summarizes current studies identifying many factors of radioresistance of glial tumors, such as hypoxia, microenvironment and metabolic features of tumor, stem cells, internal heterogeneity of tumor, microRNA, features of cell cycle, DNA damage and reparation. We obtained data on involvement of various molecular pathways in development of radioresistance such as MEK/ERK, c-MYC, PI3K/Akt, PTEN, Wnt, JAK/STAT, Notch, etc. Changes in activity of RAD51 APC, FZD1, LEF1, TCF4, WISP1, p53 and many others are determined in radioresistant cells. Further study of radioresistance pathways will allow development of specific target aptamers and inhibitors.
Keywords:
Authors:
Belyashova A.S.
Burdenko Neurosurgical Center
Galkin M.V.
Burdenko National Medical Research Center for Neurosurgery
Antipina N.A.
Burdenko Neurosurgical Center
Pavlova G.V.
Burdenko National Medical Research Center of Neurosurgery
Golanov A.V.
Burdenko Neurosurgical Center
Received:
08.08.2022
Accepted:
19.08.2022
List of references:
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