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Ikonnikova S.A.

Pirogov Russian National Research Medical University, Moscow, Russia;
Municipal Clinical Hospital No. 31 named after Academician G.M. Savelyeva, Moscow, Russia

Yasamanova A.N.

Pirogov Russian National Research Medical University, Moscow, Russia

Kamchatnov P.R.

Pirogov Russian National Research Medical University, Moscow, Russia

Kubenko A.V.

Sechenov First Moscow State Medical University, Moscow, Russia

Postischemic reperfusion and “reperfusion paradox” in ischemic stroke

Authors:

Ikonnikova S.A., Yasamanova A.N., Kamchatnov P.R., Kubenko A.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(5): 35‑42

DOI: 10.17116/jnevro202612605135

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Table of contents

POSTISCHEMIC REPERFUSION AND “REPERFUSION PARADOX” IN ISCHEMIC STROKE
POSTISCHEMIC REPERFUSION AND “REPERFUSION PARADOX” IN ISCHEMIC STROKE

To cite this article:

Ikonnikova SA, Yasamanova AN, Kamchatnov PR, Kubenko AV. Postischemic reperfusion and “reperfusion paradox” in ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(5):35‑42. (In Russ.)
https://doi.org/10.17116/jnevro202612605135

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Current therapeutic approaches for the acute phase of ischemic stroke (IS) primarily involve advanced reperfusion technologies aimed at restoring blood flow to areas with reduced perfusion. However, even with successful restoration of blood flow through the affected vessel, reperfusion injury can intensify tissue damage by exacerbating metabolic disorders and triggering programmed cell death in the ischemic region. Consequently, the effectiveness of treatment and overall outcomes are heavily influenced by the extent of reperfusion injury. This review presents the latest insights into the key stages of the ischemic-hypoxic cascade and the ischemia/reperfusion associated with IS. It discusses the characteristics of the molecular and cellular responses to postischemic reperfusion, identifies the primary factors contributing to reperfusion injury, and explores various manifestations of the «reperfusion paradox». Furthermore, the review addresses therapeutic strategies aimed at mitigating the adverse effects of hypoxia-induced damage.

Keywords:

ischemic stroke
cerebrovascular accident
postischemic reperfusion
ischemic reperfusion injury
reperfusion paradox

Authors:

Ikonnikova S.A.

Pirogov Russian National Research Medical University, Moscow, Russia;
Municipal Clinical Hospital No. 31 named after Academician G.M. Savelyeva, Moscow, Russia

Yasamanova A.N.

Pirogov Russian National Research Medical University, Moscow, Russia

Kamchatnov P.R.

Pirogov Russian National Research Medical University, Moscow, Russia

Kubenko A.V.

Sechenov First Moscow State Medical University, Moscow, Russia

Received:

12.03.2026

Accepted:

31.03.2026

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