The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Masyutina D.D.

Sverdlovsk regional clinical hospital No. 1

Alasheev A.M.

Sverdlovsk regional clinical hospital No. 1

Case series of successful thrombolytic therapy with the recombinant non-immunogenic staphylokinase in acute ischemic stroke beyond the standard therapeutic window

Authors:

Masyutina D.D., Alasheev A.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;124(10): 85‑90

DOI: 10.17116/jnevro202512510185

Read: 495 times

Buy for 300₽
Contact the author
Table of contents

CASE SERIES OF SUCCESSFUL THROMBOLYTIC THERAPY WITH THE RECOMBINANT NON-IMMUNOGENIC STAPHYLOKINASE IN ACUTE ISCHEMIC STROKE BEYOND THE STANDARD THERAPEUTIC WINDOW
CASE SERIES OF SUCCESSFUL THROMBOLYTIC THERAPY WITH THE RECOMBINANT NON-IMMUNOGENIC STAPHYLOKINASE IN ACUTE ISCHEMIC STROKE BEYOND THE STANDARD THERAPEUTIC WINDOW

To cite this article:

Masyutina DD, Alasheev AM. Case series of successful thrombolytic therapy with the recombinant non-immunogenic staphylokinase in acute ischemic stroke beyond the standard therapeutic window. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;124(10):85‑90. (In Russ.)
https://doi.org/10.17116/jnevro202512510185

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Sequential use of botu­linum toxin A and bovhyaluronidase azoximer in the correction of post-stroke spasticity. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):80-85
Central nervous system invo­lvement in systemic lupus erythematosus. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):124-129
Adju­vant pharmacological modu­lation with Cyto­flavin in reha­bilitation at stages 2—3 in patients with acute cere­bral insu­fficiency and post-intensive care syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):78-85
Cere­brolysin with repe­rfusion therapy in ischemic stroke: a prospective analysis of multimodal brain imaging data from the CERE­HETIS trial. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):84-98
Prediction of mortality in severe ischemic stroke during COVID-19 in patients with multiorgan dysfunction. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):120-127
A clinical case of treating a patient with severe ischemic stroke and cancer. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):114-117
Anesthetic mana­gement of endo­vascular procedures in patients with ischemic stroke. Russian Journal of Anesthesiology and Reanimatology. 2025;(2):20-25
Comparison of fluoroscopy and intracardiac echo­cardiography for control of endo­vascular closure of patent fora­men ovale. Russian Cardiology Bulletin. 2025;(1):64-69
Mathematical mode­ling of outcomes in patients with clinical combination of ischemic stroke and COVID-19 complicated by multiple organ failure. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):42-49
Socio-economic damage caused by elevated low-density lipo­protein cholesterol levels. Medi­cal Technologies. Asse­ssment and Choice. 2025;(2):88-98
Abstract:

A series of clinical cases of the use of a non-immunogenic staphylokinase drug (Fortelyzin, SuperGene LLC, Russia) within an extended therapeutic window (4.5—9 hours) in accordance with the EXTEND criteria in the neurological department of the Sverdlovsk Regional clinical hospital No. 1 during 2023 is presented. During therapy, all patients showed significant regression of neurological deficits both on the first day after TLT and by the time of discharge (NIHSS dynamics of more than 5 points), good functional outcomes were achieved (0—2 points on the mRS scale), there was no hemorrhagic transformation on the control CT. TLT with non-immunogenic staphylokinase in accordance with the EXTEND criteria demonstrated a favorable the effectiveness and safety profile in the presented cases. Further multicenter studies are needed to evaluate its application in the extended window. A paradigm shift from a «temporary» to a «tissue» therapeutic window based on perfusion neuroimaging is a promising direction.

Keywords:

thrombolytic therapy
Fortelyzin
the non-immunogenic staphylokinase
ischemic stroke
extended therapeutic window
EXTEND criteria
perfusion neuroimaging

Authors:

Masyutina D.D.

Sverdlovsk regional clinical hospital No. 1

Alasheev A.M.

Sverdlovsk regional clinical hospital No. 1

Received:

29.08.2025

Accepted:

17.09.2025

Close metadata

References:

  1. GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021;20(10):795-820.  https://doi.org/10.1016/S1474-4422(21)00252-0
  2. Klochihina OA, Shprakh VV, Stakhovskaya LV, et al. Indicators of stroke morbidity and mortality from stroke in the territories included in the Federal program of caring for patients with stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3-2):22-28. (In Russ.). https://doi.org/10.17116/jnevro202112103222
  3. Feigin VL, Stark BA, Johnson CO, et al. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2022;21(11):1004-1060. https://doi.org/10.1016/S1474-4422(21)00252-0
  4. Ignatyeva VI, Voznyuk IA, Shamalov NA, et al. Social and economic burden of stroke In Russian Federation. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(8-2):5-15. (In Russ.). https://doi.org/10.17116/jnevro20231230825
  5. Lees KR, Emberson J, Blackwell L, et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet. 2020;51(7):2178-2181. https://doi.org/10.1016/S0140-6736(10)60491-6
  6. Lees KR, Emberson J, Blackwell L, et al. Effects of alteplase for acute stroke on the distribution of functional outcomes: a pooled analysis of 9 trials. Stroke. 2016;47(9):2373-2379. https://doi.org/10.1161/STROKEAHA.116.013644
  7. Ministry of Health of the Russian Federation. Ischemic stroke and transient ischemic attack in adults. Clinical guidelines. M.; 2024. (In Russ.). https://cr.minzdrav.gov.ru/view-cr/814_1
  8. Skvortsova VI, Shetova IM, Kakorina EP, et al. Organization of stroke care In Russia: results of 10 years of implementing measures to improve medical care for patients with acute cerebrovascular accidents. Annaly Klinicheskoi i Eksperimental’noi Nevrologii. 2018;12(3):5-12. (In Russ.). https://doi.org/10.25692/ACEN.2018.3.1
  9. Shamalov NA. Reperfusion therapy for ischemic stroke In Russian Federation: problems and perspectives. Neurology, Neuropsychiatry, Psychosomatics. 2014;(S2):84-89. (In Russ.). https://doi.org/10.14412/2074-2711-2014-2S-15-22
  10. Regenhardt RW, Mecca AP, Flavin SA, et al. Delays in the Air or Ground Transfer of Patients for Endovascular Thrombectomy. Stroke. 2018;49(6):1419-1425. https://doi.org/10.1161/STROKEAHA.118.020618
  11. Kristiansen NS, Mainz J, Nørgård BM, et al. Off-hours admission and acute stroke care quality: a nationwide study of performance measures and case-fatality. Stroke. 2014;45(12):3663-3669. https://doi.org/10.1161/STROKEAHA.114.005535
  12. Wouters A, Lemmens R, Dupont P, Thijs V. Wake-up stroke and stroke of unknown onset: a critical review. Front Neurol. 2014;5:153.  https://doi.org/10.3389/fneur.2014.00153
  13. Naygovzina NB, Flek VO, Son IM, et al. Analysis of state guarantees for MRI in accordance with procedures for medical care approved by the Ministry of Health. Medical Technologies. Assessment and Choice. 2024;46(2):69-77. (In Russ.). https://doi.org/10.17116/medtech20244602169
  14. Albers GW, Marks MP, Kemp S, et al. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging. N Engl J Med. 2018;378(8):708-718.  https://doi.org/10.1056/NEJMoa1713973
  15. Campbell BCV, Ma H, Ringleb PA, et al. Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data. Lancet. 2019;394(10193):139-147.  https://doi.org/10.1016/S0140-6736(19)31053-0
  16. Ma H, Campbell BCV, Parsons MW, et al. Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke. N Engl J Med. 2019;380(19):1795-1803. https://doi.org/10.1056/NEJMoa1813046
  17. Altersberger VL, Sibolt G. TRISP collaborators. Intravenous Thrombolysis 4.5-9 Hours After Stroke Onset: A Cohort Study from the TRISP Collaboration. Ann Neurol. 2023;94(2):309-320.  https://doi.org/10.1002/ana.26669
  18. Gusev EI, Martynov MYu, Shamalov NA, et al. Nonimmunogenic staphylokinase in the treatment of acute ischemic stroke (FRIDA trial results). S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(7):56-65. (In Russ.). https://doi.org/10.17116/jnevro202212207156
  19. Gusev EI, Martynov MYu, Nikonov AA, et al. Non-immunogenic recombinant staphylokinase versus alteplase for patients with acute ischaemic stroke 4.5 h after symptom onset In Russia (FRIDA): a randomised, open label, multicentre, parallel-group, non-inferiority trial. Lancet Neurol. 2021;20:721-728.  https://doi.org/10.1016/S1474-4422(21)00210-6
  20. Alasheev AM, Lantsova EV, Tretyakov DA. Efficacy and safety of non-immunogenic staphylokinase in the ischemic stroke in real-world clinical practice in the Sverdlovsk region. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(7):74-79. (In Russ.). https://doi.org/10.17116/jnevro202312307174
  21. Protocol of thrombolytic therapy for ischemic stroke. Saint Petersburg; 2023. Accessed August 15, 2025. (In Russ.). https://nsnch.org/wp-content/uploads/2021/12/A5_27_01_23_all.pdf
  22. Schaefer PW, Pulli B, Copen WA, et al. Combining MRI with NIHSS thresholds to predict outcome in acute ischemic stroke: value for patient selection. Am J Neuroradiol. 2015;36(2):259-264.  https://doi.org/10.3174/ajnr.A4103
  23. Bang OY, Saver JL, Kim SJ, et al. Collateral Flow Predicts Response to Endovascular Therapy for Acute Ischemic Stroke. Stroke. 2011;42(3):693-699.  https://doi.org/10.1161/STROKEAHA.110.595256
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.