The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Savvina I.A.
Almazov National Medical Research Centre
The effect of sevoflurane and propofol on serum nuclear and mitochondrial DNA in pediatric patients with craniosynostosis
Journal: Russian Journal of Anesthesiology and Reanimatology. 2024;(6): 55‑62
Views: 581
Downloaded: 3
To cite this article:
Gurskaia VI, Ma Y, Panshin DD, et al. . The effect of sevoflurane and propofol on serum nuclear and mitochondrial DNA in pediatric patients with craniosynostosis. Russian Journal of Anesthesiology and Reanimatology.
2024;(6):55‑62. (In Russ.)
https://doi.org/10.17116/anaesthesiology202406155
Influence of general anesthetics on modulation of systemic inflammatory response, neuronal damage and neuroapoptosis is important and associated with neurotoxic effect on developing brain and further neurocognitive disorders.
To analyze extracellular nucleic acids (nuclear DNA and mitochondrial DNA) in peripheral blood of pediatric patients with craniosynostosis under inhalation anesthesia with sevoflurane and intravenous sedation with propofol undergoing MRI of the brain before neurosurgical intervention.
A prospective cohort controlled study included 46 children with craniosynostosis (sevoflurane group, n=23; propofol group, n=23) and 20 healthy volunteers (10 children and 10 adults) as a control group. The content of nuclear (nDNA) and mitochondrial (mtDNA) DNA was assessed before general anesthesia and immediately after procedure. We compared these data with nDNA and mtDNA in healthy volunteers.
Serum nDNA (p<0.001) and mtDNA (p=0.013) were higher in healthy children compared to healthy adult volunteers. Nuclear DNA decreases (p=0.043) in children with craniosynostosis after inhalational anesthesia with sevoflurane, whereas mtDNA remains unchanged. Propofol has no effect on nDNA and mtDNA.
Sevoflurane and propofol has either neutral or inhibitory effect on circulating nuclear and mitochondrial DNA.
Keywords:
Authors:
Savvina I.A.
Almazov National Medical Research Centre
Received:
03.02.2024
Accepted:
17.07.2024
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.