Biochemical features of migraine pathogenesis

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The article addresses the main mechanisms of migraine pathogenesis in terms of biochemical features (neurotransmitter metabolism, neurochemistry, neurophysiology, and neurogenetics). The effect of hormones, electrolytes (magnesium, calcium, sodium), vitamins (vitamin D, B₁₂), and other biologically active molecules (melatonin, L-carnitine, L-tryptophan) on the course of the disease is considered. Including some laboratory tests in the migraine diagnostic algorithm helps identify the secondary nature of headache and/or dizziness, manage therapeutic approaches, and adjust the prognosis and treatment outcomes.

Keywords:

migraine

vestibular migraine

hormones

vitamins

micronutrients

neurotransmitters

Authors:

Kunelskaya N.L.

L. I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

ORCID: 0000-0002-1001-2609

Zaoeva Z.O.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-2501-0200

Vasilchenko N.O.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

ORCID: 0009-0001-2904-1733

Chugunova M.A.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-4632-7901

Revazishvili S.D.

L.I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology

ORCID: 0009-0009-5089-6216

Received:

13.12.2024

Accepted:

19.12.2024

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