Oxidative stress in the pathogenesis of chronic headache

Fedin A.I.

doi:https://doi.org/10.17116/jnevro202412410135

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Abstract:

Given new information about the development of oxidative stress (OS) in chronic headache. The main biochemical characteristics of OS are presented. Changes in MRI and biochemical markers confirming the development of OS in migraine are described. The absence of significant differences in OS rates for migraine without aura and with aura is emphasized. The pathophysiological differences between migraine and chronic tension headache, in which OS is not detected, are shown. The possible activation of TRPA1 ion channels and CGRP peptides during OS, which provokes migraine attacks, is discussed. Directions of pathogenetic therapy OS are given.

Keywords:

headache

migraine

tension-type headache

oxidative stress

Authors:

Fedin A.I.

Pirogov Russian National Research Medical University

SPIN RSCI: 8834-0085
Scopus AuthorID: 7007163263
ORCID: 0000-0002-6996-2828

Received:

09.09.2024

Accepted:

16.09.2024

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