Nutrition, intestinal microbiota, and thyroid autoimmune pathology

Eliashevich S.O.; Zimina P.A.; Drapkina O.M.

doi:https://doi.org/10.17116/profmed202528011102

Елиашевич С.О.

ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России

ORCID: 0000-0003-0143-0849

Зимина П.А.

ORCID: 0000-0002-7289-7713

Драпкина О.М.

SPIN РИНЦ: 4456-1297
Scopus AuthorID: 57208852308
ResearcherID: G-8443-2016
ORCID: 0000-0002-4453-8430

Питание, кишечная микробиота и аутоиммунная патология щитовидной железы

Авторы:

Елиашевич С.О., Зимина П.А., Драпкина О.М.

Подробнее об авторах

Журнал: Профилактическая медицина. 2025;28(1): 102‑108

DOI: 10.17116/profmed202528011102

Прочитано: 998 раз

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Оглавление

Как цитировать:

Елиашевич С.О., Зимина П.А., Драпкина О.М. Питание, кишечная микробиота и аутоиммунная патология щитовидной железы. Профилактическая медицина. 2025;28(1):102‑108.
Eliashevich SO, Zimina PA, Drapkina OM. Nutrition, intestinal microbiota, and thyroid autoimmune pathology. Russian Journal of Preventive Medicine. 2025;28(1):102‑108. (In Russ.)
https://doi.org/10.17116/profmed202528011102

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)

Использование инфографики авторами научных работ

Резюме / Abstract:

Влияние кишечной микробиоты на щитовидную железу является предметом исследований с 1960 г. и находит подтверждение в современных публикациях. В данном обзоре раскрыты механизмы регуляции всасывания в кишечнике макроэлементов и микроэлементов, участвующих в регуляции гормональной оси гипоталамус—гипофиз—щитовидная железа, представлены современные взгляды на эффективность и безопасность ряда рекомендаций по питанию при патологии щитовидной железы.

Ключевые слова / Keywords:

щитовидная железа

кишечная микробиота

аутоиммунный протокол

палео-диета

средиземноморская диета

противовоспалительная диета

безглютеновая диета

микроэлементы

Авторы / Authors:

Елиашевич С.О.

ORCID: 0000-0003-0143-0849

Зимина П.А.

ORCID: 0000-0002-7289-7713

Драпкина О.М.

SPIN РИНЦ: 4456-1297
Scopus AuthorID: 57208852308
ResearcherID: G-8443-2016
ORCID: 0000-0002-4453-8430

Дата поступления:

22.07.2024

Дата принятия в печать:

30.07.2024

Закрыть метаданные

Литература / References:

Virili C, Stramazzo I, Bagaglini MF, et al. The relationship between thyroid and human-associated microbiota: A systematic review of reviews. Reviews in Endocrine and Metabolic Disorders. 2024;25(1):215-237. https://doi.org/10.1007/s11154-023-09839-9
Bargiel P, Szczuko M, Stachowska L, et al. Microbiome Metabolites and Thyroid Dysfunction. Journal of Clinical Medicine. 2021;10(16):3609. https://doi.org/10.3390/jcm10163609
Danailova Y, Velikova T, Nikolaev G, et al. Nutritional Management of Thyroiditis of Hashimoto. International Journal of Molecular Sciences. 2021; 23(9):5144. https://doi.org/10.3390/ijms23095144
Lauritano EC, Bilotta AL, Gabrielli M, et al. Association between hypothyroidism and small intestinal bacterial overgrowth. The Journal of Clinical Endocrinology and Metabolism. 2007;92(11):4180-4184. https://doi.org/10.1210/jc.2007-0606
Zhou L, Li X, Ahmed A, et al. Gut microbe analysis between hyperthyroid and healthy individuals. Current Microbiology. 2014;69(5):675-680. https://doi.org/10.1007/s00284-014-0640-6
Chiovato L, Magri F, Carlé A. Hypothyroidism in Context: Where We’ve Been and Where We’re Going. Advances in Therapy. 2019;36(Suppl 2):47-58. https://doi.org/10.1007/s12325-019-01080-8
Angum F, Khan T, Kaler J, et al. The Prevalence of Autoimmune Disorders in Women: A Narrative Review. Cureus. 2020;12(5):e8094. https://doi.org/10.7759/cureus.8094
Jiang W, Lu G, Gao D, et al. The relationships between the gut microbiota and its metabolites with thyroid diseases. Frontiers in Endocrinology. 2022; 13,943408. https://doi.org/10.3389/fendo.2022.943408
Zhu X, Zhang C, Feng S, et al. Intestinal microbiota regulates the gut-thyroid axis: the new dawn of improving Hashimoto thyroiditis. Clinical and Experimental Medicine. 2024;24(1):39. https://doi.org/10.1007/s10238-024-01304-4
Ruggeri RM, Giovinazzo S, Barbalace MC, et al. Influence of Dietary Habits on Oxidative Stress Markers in Hashimoto’s Thyroiditis. Thyroid. 2021; 31(1):96-105. https://doi.org/10.1089/thy.2020.0299
Giannakou M, Saltiki K, Mantzou E, et al. The effect of obesity and dietary habits on oxidative stress in Hashimoto’s thyroiditis. Endocrine Connections. 2018;1,990-997. https://doi.org/10.1530/EC-18-0272
Bellastella G, Scappaticcio L, Caiazzo F, et al. Mediterranean Diet and Thyroid: An Interesting Alliance. Nutrients. 2022;14:4130. https://doi.org/10.3390/nu14194130
Ratajczak AR, Moszak M, Grzymisławski M. Dietary recommendations for hypothyroidism and Hashimoto’s disease. Nursing and Public Health. 2017; 7:305-311.
Dhaliwal SK, Talukdar A, Gautam A, et al. Developments and Prospects in Imperative Underexploited Vegetable Legumes Breeding: A Review. International journal of molecular sciences. 2020;21(24):9615. https://doi.org/10.3390/ijms21249615
Rizzo G, Baroni L. Soy, soy foods and the role in vegetarian diet. Nutrients. 2018;10(1):43. https://doi.org/10.3390/nu10010043
Hurtado-Barroso S, Tressera-Rimbau A, Valleverdù-Queralt A, et al. Organic food and impact on human health. Critical Reviews in Food Science and Nutrition. 2019;59(4):704-714. https://doi.org/10.1080/10408398.2017.1394815
Dore MP, Fanciulli G, Rouatbi M, et al. Autoimmune Thyroid Disorders Are More Prevalent in Patients with Celiac Disease: A Retrospective Case-Control Study. Journal of Clinical Medicine. 2022;11(20):6027. https://doi.org/10.3390/jcm11206027
Virili C, Bassotti G, Santaguida MG, et al. Atypical celiac disease as cause of increased need for thyroxine: A systematic study. Journal of Clinical Endocrinology and Metabolism. 2012;97(3):E419-E422. https://doi.org/10.1210/jc.2011-1851
Liontiris MI, Mazokopakis EE. A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients. Points that need more investigation. Hellenic Journal of Nuclear Medicine. 2017;20(1):51-56.
Roy A, Laszkowska M, Sundström J, et al. Prevalence of celiac disease in patients with autoimmune thyroid disease: a meta-analysis. Thyroid. 2016; 26(7):880-890. https://doi.org/10.1089/thy.2016.0108
Malandrini S, Trimboli P, Guzzaloni G, et al. What about TSH and Anti-Thyroid Antibodies in Patients with Autoimmune Thyroiditis and Celiac Disease Using a Gluten-Free Diet? A Systematic Review. Nutrients. 2022; 14(8):1681. https://doi.org/10.3390/nu14081681
Abbott RD, Sadowski A, Alt AG. Efficacy of the Autoimmune Protocol Diet as Part of a Multi-Disciplinary, Supported Lifestyle Intervention for Hashimoto’s Thyroiditis. Cureus. 2019;11(4):e4556.
Al-Bayyari, N. Successful Dietary Intervention Plan for Hashimoto’s Thyroiditis: A Case Study. The Romanian Journal of Diabetes, Nutrition and Metabolic Diseases. 2020;27(4):381-385.
Lisco G, De Tullio A, Triggiani D, et al. Iodine deficiency and iodine prophylaxis: An overview and update. Nutrients. 2023;15(4):1004. https://doi.org/10.3390/nu15041004
Chaves Lopez C, Serio A, Rossi C, et al. Effect of diet supple- mentation with Ascophyllum nodosum on cow milk composition and microbiota. Journal of Dairy Science. 2016;99(8):6285-6297. https://doi.org/10.3168/jds.2015-10837
Shen H, Han J, Li Y, et al. Different host-specific responses in thyroid function and gut microbiota modulation between diet-induced obese and normal mice given the same dose of iodine. Applied Microbiology and Biotechnology. 2019;103(8):3537-3547. https://doi.org/10.1007/s00253-019-09687-1
Fröhlich E, Wahl R. Microbiota and thyroid interaction in health and disease. Trends in Endocrinology and Metabolism. 2019;30(8):479-490. https://doi.org/10.1016/j.tem.2019.05.008
Knezevic J, Starchl C, Tmava Berisha A, et al. Thyroid-Gut-Axis: how does the microbiota influence thyroid function? Nutrients. 2020;12(6):1769. https://doi.org/10.3390/nu12061769
Stramazzo I, Capriello S, Filardo S, et al. Microbiota and thyroid disease: An updated systematic review. Advances in Experimental Medicine and Biology. 2023;1370:125-144. https://doi.org/10.1007/5584_2023_770
Абдулхабирова Ф.М., Безлепкина О.Б., Бровин Д.Н., и др. Клинические рекомендации «Заболевания и состояния, связанные с дефицитом йода». Проблемы эндокринологии. 2021;67(3):10-25. https://doi.org/10.14341/probl12750
Wu Q, Wang Y, Chen P, et al. Increased incidence of Hashimoto Thyroiditis in selenium deficiency: A prospective 6-Year Cohort Study. The Journal of Clinical Endocrinology and Metabolism. 2022;107(9):e3603-e3611. https://doi.org/10.1210/clinem/dgac410
Giacconi R, Chiodi L, Boccoli G, et al. Reduced levels of plasma selenium are associated with increased inflammation and cardiovascular disease in an Italian elderly population. Experimental Gerontology. 2021;145:111219. https://doi.org/10.1016/j.exger.2020.111219
Wang F, Li C, Li S, et al. Selenium and thyroid diseases. Frontiers in Endocrinology. 2023;14:1133000. https://doi.org/10.3389/fendo.2023.1133000
Drutel A, Caron P. Selenium and the thyroid gland: More good news for clinicians. Clinical Endocrinology. 2013;78(2):155-164. https://doi.org/10.1111/cen.12066
Wichman J, Winther KH, Bonnema SJ, et al. Selenium Supplementation Significantly Reduces Thyroid Autoantibody Levels in Patients with Chronic Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis. Thyroid. 2016;26(12):1681-1692. https://doi.org/10.1089/thy.2016.0256
Wu Q, Rayman MP, Lv H, et al. Low population selenium status is associated with increased prevalence of thyroid disease. The Journal of Clinical Endocrinology and Metabolism. 2015;100(11):4037-4047. https://doi.org/10.1210/jc.2015-2222
Kawicka A, Regulska-Ilow B. Metabolic disorders and nutritional status in autoimmune thyroid diseases. Postepy Higieny i Medycyny Doswiadczalnej (Online). 2015;69:80-90.
Zhang H, Teng X, Shan Z, et al. Association between iron deficiency and prevalence of thyroid autoimmunity in pregnant and non-pregnant women of childbearing age: A cross-sectional study. Chiniese Medical Journal. 2019;132(18):2143-2149. https://doi.org/10.1097/CM9.0000000000000409
Duntas LH. Nutrition and thyroid disease. Current Opinion in Endocrinology, Diabetes, and Obesity. 2023;30(6):324-329. https://doi.org/10.1097/MED.0000000000000831
Arora M. Study of trace elements in patients of hypothyroidism with special reference to zinc and copper. Biomedical Journal of Scientific and Technical Research. 2018;6(2):11-16.
Macvanin MT, Gluvic Z, Zafirovic S, et al. The protective role of nutritional antioxidants against oxidative stress in thyroid dis- orders. Frontiers in Endocrinology. 2023;13:1092837. https://doi.org/10.3389/fendo.2022.1092837
Liu Q, Sun W, Zhang H. Interaction of gut microbiota with endocrine homeostasis and thyroid cancer. Cancers (Basel). 2022;14(11):2656. https://doi.org/10.3390/cancers14112656
Hu S, Rayman MP. Multiple Nutritional Factors and the Risk of Hashimoto’s Thyroiditis. Thyroid. 2017;27(5):597-610. https://doi.org/10.1089/thy.2016.0635
Shin DY, Kim KJ, Kim D, et al. Low Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis. Yonsei Medical Journal. 2014;55(2):476-481. https://doi.org/10.3349/ymj.2014.55.2.476
D’Aurizio F, Villalta D, Metus P, et al. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmunity Reviews. 2015;14(5):363-369. https://doi.org/10.1016/j.autrev.2014.10.008
Sajadi Hezaveh Z, Shidfar F. Probiotic and hypothyroidism. In: OlsenY, ed. Probiotics and their role in health and disease. Nova Science Publishers, Inc.; 2021: 123-170.
Zawadzka K, Kałuzińska K, Świerz MJ, et al. Are probiotics, prebiotics, and synbiotics beneficial in primary thyroid diseases? A systematic review with meta-analysis. Annals of Agricultural and Environmental Medicine. 2023; 30(2):217-223. https://doi.org/10.26444/aaem/162732
Larsen D, Singh S, Brito M. Thyroid, Diet, and Alternative Approaches. The Journal of Clinical Endocrinology and Metabolism. 2022;107(11):2973-2981. https://doi.org/10.1210/clinem/dgac473
Otun J, Sahebkar A, Östlundh L, et al. Systematic Review and Meta-analysis on the Effect of Soy on Thyroid Function. Scientific Reports. 2019;9(1):3964. https://doi.org/10.1038/s41598-019-40647-x
Mikulska AA, Karaźniewicz-Łada M, Filipowicz D, et al. Metabolic Characteristics of Hashimoto’s Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management-An Overview. International Journal of Molecular Sciences. 2022;23(12):6580. https://doi.org/10.3390/ijms23126580