OBJECTIVE

To study the features and mechanisms of development of oxidative stress in animal models during sleep deprivation.

MATERIAL AND METHODS

The experiments were carried out on 6-month-old male rats (n=60), which were divided equally into 3 groups. Group 1 included intact animals, groups 2 and 3 were subjected to modeling of chronic sleep deprivation using the method of cyclic sleep restriction. Animals of group 3, in addition to the standard diet, received resveratrol (10 mg/kg, intragastric) daily. On days 0, 1, 3 and 5 of the experiment, the activity of antioxidant enzymes and the concentration of peroxidation products in the blood serum was assessed.

RESULTS

Sleep deprivation in animal models causes an intensification of oxidative processes (increased concentrations of malondialdehyde and diene conjugates) and a decrease in the activity of antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase).

CONCLUSION

Sleep deprivation contributes to the accumulation of highly toxic products of lipid peroxidation in the body tissues, which is reflected in metabolic disorders, and a decrease in adaptive capabilities. Additional administration of resveratrol helps to reduce the amplitude of fluctuations in redox balance, which can be considered as a possible way to correct oxidative stress and prevent disorders associated with sleep restriction and dysregulation of the sleep—wake cycle.