Arterial hypertension is an oxidative stress, as a pathogenetic target for the treatment of chronic cerebrovascular insufficiency

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The increase in the development of arterial hypertension (AH), as the main modifiable risk factor for the development of acute and chronic cerebral circulatory insufficiency, often leading to a progressive decrease in cognitive status and physical activity, requires early detection and effective pathogenetic therapy. The breadth of therapeutic effects of the drug Mexidol (ethylmethylhydroxypyridine succinate) due to the multifactorial nature of its pathogenetic effects contributes to its widespread use. The safe profile of Mexidol use and the absence of drug interaction makes it relevant in the complex treatment of patients with cardiovascular diseases.

Keywords:

arterial hypertension

oxidative stress

cerebral circulatory insufficiency

cognitive functions

endothelial sensitivity

G-protein coupled receptor 91 (GPR91)

succinate

ethylmethylhydroxypyridine succinate

Mexidol

Authors:

Chukanova E.I.

Pirogov Russian National Research Medical University (Pirogov University)

ORCID: 0000-0002-3291-9615

Chukanova A.S.

Pirogov Russian National Research Medical University (Pirogov University)

ORCID: 0000-0003-0940-782X

Andrianov D.D.

Pirogov Russian National Research Medical University (Pirogov University)

ORCID: 0009-0000-6917-4277

Received:

19.12.2024

Accepted:

26.12.2024

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