Psoriasis: analysis of comorbid pathology

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BACKGROUND

Chronic nature of course and presence of systemic inflammation in psoriasis are accompanied by the development of a great number of comorbid disorders, which not only lead to social maladjustment, but also directly affect patients’ survival. For clinicians, diagnostic search of co-occuring disorders in psoriasis during routine practice is often difficult due to their great diversity, different incidence and pronouncement of associations with the main disease.

OBJECTIVE

To study the structure of comorbid disorders in patients with psoriasis.

MATERIAL AND METHODS

A number of patients with the established diagnosis of «psoriasis» equal 509 was investigated from 2018 to 2021. All patients underwent examination with an assessment of the clinical course of psoriasis, the data of medical history were taken into account. The detection and analysis of comorbid disorders was carried out by patient’s clinical examination with further study of medical documentation.

RESULTS

Comorbid disorders have been noted in 224 (44%) patients. Psoriatic arthritis (143/63.8%), arterial hypertension (113/50.4%) and ischemic heart disease (27/12.5%) were the most common impairments. In addition, type II diabetes mellitus (17/7.6%), nephrolithiasis (16/7.1%), chronic glomerulonephritis (16/7.1%) and digestive system lesions with signs of chronic pancreatitis (23/10%) have been registered.

CONCLUSION

The study and analysis of comorbid disorders in patients with psoriasis plays an important role in maintaining health and quality of life of patients. Clinicians should pay attention to the patient’s overall health status, in addition to the pathological process on the skin, with emphasis on possible lesions of the osteoarticular, cardiovascular and other systems.

Keywords:

psoriasis

comorbidity

diabetes mellitus

psoriatic arthritis

cardiovascular diseases

oxidative stress

Authors:

Saranyuk R.V.

Kursk State Medical University;
Society of integrative dermatology

ORCID: 0000-0001-9676-1581

Polonikov A.V.

Kursk State Medical University

ORCID: 0000-0001-6280-247X

Received:

03.06.2024

Accepted:

08.12.2024

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