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Semenova N.V.

Scientific Centre for Family Health and Human Reproduction Problems

Lesnaya A.S.

Scientific Centre for Family Health and Human Reproduction Problems

Madaeva I.M.

Scientific Centre for Family Health and Human Reproduction Problems

Nikitina O.A.

Scientific Centre for Family Health and Human Reproduction Problems

Kolesnikova L.I.

Scientific Centre for Family Health and Human Reproduction Problems

Carbonyl stress in menopausal women with insomnia

Authors:

Semenova N.V., Lesnaya A.S., Madaeva I.M., Nikitina O.A., Kolesnikova L.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(11): 192‑197

DOI: 10.17116/jnevro2024124111192

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Table of contents

CARBONYL STRESS IN MENOPAUSAL WOMEN WITH INSOMNIA
CARBONYL STRESS IN MENOPAUSAL WOMEN WITH INSOMNIA

To cite this article:

Semenova NV, Lesnaya AS, Madaeva IM, Nikitina OA, Kolesnikova LI. Carbonyl stress in menopausal women with insomnia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(11):192‑197. (In Russ.)
https://doi.org/10.17116/jnevro2024124111192

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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OBJECTIVE

To assess the level of advanced oxidation protein products (AOPP) and advanced glycation end products (AGEs) in menopausal women with insomnia.

MATERIAL AND METHODS

One hundred and thirty-six menopausal women were examined. After collecting medical history, general clinical examination, examination by a gynecologist and identifying the presence and nature of sleep disorders, the subjects were divided into 4 groups: 1 — control/perimenopause (n=21); 2 — insomnia/perimenopause (n=34); 3 — control/postmenopause (n=31); 4 — insomnia/postmenopause (n=50). The content of AOPP and the level of AGEs were determined using enzyme immunoassay.

RESULTS

A high percentage of menopausal women with insomnia have carbonyl stress values above the confidence interval (AGEs — 49.2% of women, AOPP — 55.2%). The insomnia in perimenopause is associated with high levels of AGEs (4533.10 [3834.09; 5098] ng/ml, p=0.039) and AOPP (28.92 [22.27; 40] nmol/L, p=0.002) as compared to controls (3685.87 [3376.11; 4318] ng/ml and 19.8 [16.85; 23.97] nmol/L, respectively). There are no significant differences in the studied parameters in postmenopause with insomnia.

CONCLUSION

Insomnia in perimenopause is a provoking factor for the development of free radical pathology and is associated with the formation of carbonyl stress, and in postmenopause it does not make significant changes in metabolic pathways involving carbonyl compounds.

Keywords:

carbonyl stress
insomnia
advanced oxidation protein products
advanced glycation end products
climacteric

Authors:

Semenova N.V.

Scientific Centre for Family Health and Human Reproduction Problems

Lesnaya A.S.

Scientific Centre for Family Health and Human Reproduction Problems

Madaeva I.M.

Scientific Centre for Family Health and Human Reproduction Problems

Nikitina O.A.

Scientific Centre for Family Health and Human Reproduction Problems

Kolesnikova L.I.

Scientific Centre for Family Health and Human Reproduction Problems

Received:

17.02.2024

Accepted:

22.02.2024

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