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Klochkova O.A.

Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery

Kurenkov A.L.

National Medical Research Center for Children’s Health;
LLC «Center of Interdisciplinary Dentistry and Neurology»

Argunova G.V.

Russian Rehabilitation Center «Childhood

Duibanova N.V.

Children’s Republican Clinical Hospital

Zatravkina T.Yu.

V.I. Razumovsky Saratov State Medical University (Razumovsky University)

Krasavina D.A.

Saint Petersburg State Pediatric Medical University

Lukyanova E.G.

V.F. Voyno-Yasenetsky Scientific and Practical Center of Specialized Medical Care for Children

Nekrasova A.M.

LLC «Kazan Institute of Traumatology and Orthopedics»

Okhapkina T.G.

Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University (Pirogov University)

Sereda E.O.

V.A. Almazov National Medical Research Center

Falkovsky I.V.

LLC «Neyroklinika»

Khrulev S.E.

Privolzhsky Research Medical University

Abobotulinumtoxin A injections for the chronic sialorrhea correction in children: Russian retrospective multicenter study

Authors:

Klochkova O.A., Kurenkov A.L., Argunova G.V., Duibanova N.V., Zatravkina T.Yu., Krasavina D.A., Lukyanova E.G., Nekrasova A.M., Okhapkina T.G., Sereda E.O., Falkovsky I.V., Khrulev S.E.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(1): 53‑61

DOI: 10.17116/jnevro202512501153

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Table of contents

ABOBOTULINUMTOXIN A INJECTIONS FOR THE CHRONIC SIALORRHEA CORRECTION IN CHILDREN: RUSSIAN RETROSPECTIVE MULTICENTER STUDY
ABOBOTULINUMTOXIN A INJECTIONS FOR THE CHRONIC SIALORRHEA CORRECTION IN CHILDREN: RUSSIAN RETROSPECTIVE MULTICENTER STUDY

To cite this article:

Klochkova OA, Kurenkov AL, Argunova GV, et al. . Abobotulinumtoxin A injections for the chronic sialorrhea correction in children: Russian retrospective multicenter study. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(1):53‑61. (In Russ.)
https://doi.org/10.17116/jnevro202512501153

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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OBJECTIVE

Multicenter retrospective analysis of the Russian experience in the use of AbobotulinumtoxinA injections for the correction of chronic sialorrhea of various etiologies in children.

MATERIAL AND METHODS

608 injections (from 1 to 5 repeated injections) of the AbobotulinumtoxinA into the salivary glands for 226 patients aged 2.0 to 17.8 years (Me — 5.1 years) with various neurological diseases and neurodevelopmental disorders in 12 Russian centers.

RESULTS

In 180 patients (79.6%), AbobotulinumtoxinA was the first drug used to correct drooling. 177 (78.3%) children received combined injections into the salivary glands and body muscles to correct spasticity. The total doses of AbobotulinumtoxinA administered into the salivary glands during the first injection were (Med; min—max; 25—75%):150 U (7.7 U/kg); 30—400 U (1.9—27.3); 100—200 units (4.8—15.3). Doses to both parotid glands — 80 units (4.1 units/kg); 18—250 U (0.8—15.4 U/kg); 60—120 U (2.7—8.5 U/kg); in both submandibular — 70 U (3.3 U/kg); 12—160 U (0.5—13.6 U/kg); 40—80 U (2.1—6.1 U/kg). After the first injection of AbobotulinumtoxinA, a significant decrease in salivation was observed in 212 cases (93.8%). The effect lasted for an average of 4.9 months (0.5 to 24 months). Changes in the Drooling Impact Scale and subjective duration of effect were not significantly different after repeated injections. Adverse events were noted in 30 (13.3%) cases and persisted up to 2—3 weeks after injection.

CONCLUSION

AbobotulinumtoxinA injections have shown effectiveness and safety in the correction of chronic sialorrhea in children, also in combination with concomitant spasticity treatment. Further research is needed to determine the optimal dose and treatment protocols.

Keywords:

cerebral palsy
sialorrhea
dysphagia
oromotor dysfunction
AbobotulinumtoxinA
neurodevelopmental disorder
botulinum toxin treatment
botulinum toxin A

Authors:

Klochkova O.A.

Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery

Kurenkov A.L.

National Medical Research Center for Children’s Health;
LLC «Center of Interdisciplinary Dentistry and Neurology»

Argunova G.V.

Russian Rehabilitation Center «Childhood

Duibanova N.V.

Children’s Republican Clinical Hospital

Zatravkina T.Yu.

V.I. Razumovsky Saratov State Medical University (Razumovsky University)

Krasavina D.A.

Saint Petersburg State Pediatric Medical University

Lukyanova E.G.

V.F. Voyno-Yasenetsky Scientific and Practical Center of Specialized Medical Care for Children

Nekrasova A.M.

LLC «Kazan Institute of Traumatology and Orthopedics»

Okhapkina T.G.

Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University (Pirogov University)

Sereda E.O.

V.A. Almazov National Medical Research Center

Falkovsky I.V.

LLC «Neyroklinika»

Khrulev S.E.

Privolzhsky Research Medical University

Received:

09.12.2024

Accepted:

27.12.2024

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