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Krasavina D.A.

Saint Petersburg State Pediatric Medical University

Ivanov D.O.

St. Petersburg State Pediatric Medical University

Orlova O.R.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Valiev V.K.

LLC «Professor’s Clinic «ODA»

Yakovleva P.N.

Central Institute of Botulinum Therapy and Actual Neurology LLC

Akulov M.A.

N.N. Burdenko Neurosurgical Center

Sequential use of botulinum toxin A and bovhyaluronidase azoximer in the correction of post-stroke spasticity

Authors:

Krasavina D.A., Ivanov D.O., Orlova O.R., Valiev V.K., Yakovleva P.N., Akulov M.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(2): 80‑85

DOI: 10.17116/jnevro202512502180

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Table of contents

SEQUENTIAL USE OF BOTULINUM TOXIN A AND BOVHYALURONIDASE AZOXIMER IN THE CORRECTION OF POST-STROKE SPASTICITY
SEQUENTIAL USE OF BOTULINUM TOXIN A AND BOVHYALURONIDASE AZOXIMER IN THE CORRECTION OF POST-STROKE SPASTICITY

To cite this article:

Krasavina DA, Ivanov DO, Orlova OR, Valiev VK, Yakovleva PN, Akulov MA. Sequential use of botulinum toxin A and bovhyaluronidase azoximer in the correction of post-stroke spasticity. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(2):80‑85. (In Russ.)
https://doi.org/10.17116/jnevro202512502180

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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A clinical case of consistent use of botulinum toxin type A (BTA) and azoximer bovhialuronidase (BA) in a 69-year-old patient who suffered an ischemic stroke (II) with right-sided hemiparesis is presented. BTA (incobotulotoxin) was injected under ultrasound control (ultrasound) into the muscles of the target pathological patterns at a dose of 500 units. After 3 weeks, under the control of ultrasound navigation, BA was injected into the 2 most fibrotic shoulder muscles at a dose of 3.000 IU (1.500 IU each). The effectiveness of therapy was monitored using a modified Ashworth scale (MAS), goniometry, and electromyography. A decrease in the severity of the leading pattern of spasticity of the muscles of the upper extremity (on the MAS scale) after injection of BTA was found. After consistent application of BA, a distinct change in the structure of muscle tissue and a decrease in tone in spastic muscles were recorded. The results obtained confirm the safety of botulinum therapy and the good tolerability and efficacy of Xeomin in a patient with spasticity with contracture formation after AI. The introduction of ASTHMA after botulinum therapy makes it possible to increase the elasticity of spastic muscles by reducing the severity of fibrous changes and improving motor function.

Keywords:

bovhyaluronidase azoximer
ischemic stroke
spasticity
rehabilitation
botulinum toxin type A

Authors:

Krasavina D.A.

Saint Petersburg State Pediatric Medical University

Ivanov D.O.

St. Petersburg State Pediatric Medical University

Orlova O.R.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Valiev V.K.

LLC «Professor’s Clinic «ODA»

Yakovleva P.N.

Central Institute of Botulinum Therapy and Actual Neurology LLC

Akulov M.A.

N.N. Burdenko Neurosurgical Center

Received:

23.01.2025

Accepted:

11.02.2025

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