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Smirnov V.V.
Institute of Immunology;
Sechenov First Moscow State Medical University (Sechenov University)
Turenko V.N.
Institute of Immunology;
Sechenov First Moscow State Medical University (Sechenov University)
Bagaev D.E.
Institute of Immunology;
Sechenov First Moscow State Medical University (Sechenov University)
Immunogenicity of botulinum toxin products: the emergence of resistance and ways to overcome it
Journal: Plastic Surgery and Aesthetic Medicine. 2025;(1): 125‑134
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To cite this article:
Smirnov VV, Turenko VN, Bagaev DE, Temnova VV, Khodzhava MV. Immunogenicity of botulinum toxin products: the emergence of resistance and ways to overcome it. Plastic Surgery and Aesthetic Medicine.
2025;(1):125‑134. (In Russ., In Engl.)
https://doi.org/10.17116/plast.hirurgia2025011125
The paper presents a comprehensive view on the immunogenicity of botulinum toxin A products, analyzes the main causes of the immune response, its enhancing factors, and the further impact on the effectiveness of therapy. The overall statistics of resistance to various products both in clinical practice and when used in cosmetology are presented. The relationships between the composition of botulinum toxin A products, their immunogenicity, and the incidence of botulinum toxin resistance are evaluated; the main ways of overcoming it and minimizing the production of neutralizing antibodies are shown.
Keywords:
Authors:
Smirnov V.V.
Institute of Immunology;
Sechenov First Moscow State Medical University (Sechenov University)
Turenko V.N.
Institute of Immunology;
Sechenov First Moscow State Medical University (Sechenov University)
Bagaev D.E.
Institute of Immunology;
Sechenov First Moscow State Medical University (Sechenov University)
Received:
22.12.2024
Accepted:
20.01.2025
List of references:
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