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Kovalev V.V.

Burnasian State Research Medical Center

Bril E.V.

Burnasian State Research Medical Center;
Russian Medical Academy of Continuous Professional Education

Semenov M.S.

Burnasian State Research Medical Center

Lepsveridze L.T.

Burnasian State Research Medical Center

Seliverstov Yu.A.

Kazaryan Center of Epileptology and Neurology

Suponeva N.A.

Research Center of Neurology

Povalyaeva E.A.

Burnasian State Research Medical Center

Chronic epidural spinal cord stimulation for gait impairments in Parkinson’s disease and atypical parkinsonism

Authors:

Kovalev V.V., Bril E.V., Semenov M.S., Lepsveridze L.T., Seliverstov Yu.A., Suponeva N.A., Povalyaeva E.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(11): 100‑112

DOI: 10.17116/jnevro2024124111100

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Table of contents

CHRONIC EPIDURAL SPINAL CORD STIMULATION FOR GAIT IMPAIRMENTS IN PARKINSON’S DISEASE AND ATYPICAL PARKINSONISM
CHRONIC EPIDURAL SPINAL CORD STIMULATION FOR GAIT IMPAIRMENTS IN PARKINSON’S DISEASE AND ATYPICAL PARKINSONISM

To cite this article:

Kovalev VV, Bril EV, Semenov MS, Lepsveridze LT, Seliverstov YuA, Suponeva NA, Povalyaeva EA. Chronic epidural spinal cord stimulation for gait impairments in Parkinson’s disease and atypical parkinsonism. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(11):100‑112. (In Russ.)
https://doi.org/10.17116/jnevro2024124111100

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Spinal cord stimulation is a well-established, minimally invasive surgical technique that has been effectively utilized for the treatment of chronic pain syndromes. In the past 15 years, there has been a significant increase in reports on the use of spinal stimulation for patients with advanced Parkinson’s disease (PD), as well as in isolated cases of atypical parkinsonism. These reports frequently highlight a positive impact of spinal stimulation on gait impairments. A hallmark symptom of advanced PD, as well as several phenotypes of progressive supranuclear palsy, is the freezing of gait phenomenon. This condition, akin to postural instability, is likely linked to disruptions in multimodal integration across various levels of locomotor control. Given its poor responsiveness to dopaminergic therapy, freezing of gait remains one of the most debilitating symptoms in parkinsonism. This review consolidates current knowledge on the use of chronic epidural spinal cord stimulation in patients with PD and atypical parkinsonism, with a focus on its potential to alleviate locomotor disorders, particularly freezing of gait.

Keywords:

Parkinson’s disease
atypical parkinsonism
progressive supranuclear palsy
chronic epidural spinal cord stimulation
freezing of gait

Authors:

Kovalev V.V.

Burnasian State Research Medical Center

Bril E.V.

Burnasian State Research Medical Center;
Russian Medical Academy of Continuous Professional Education

Semenov M.S.

Burnasian State Research Medical Center

Lepsveridze L.T.

Burnasian State Research Medical Center

Seliverstov Yu.A.

Kazaryan Center of Epileptology and Neurology

Suponeva N.A.

Research Center of Neurology

Povalyaeva E.A.

Burnasian State Research Medical Center

Received:

16.10.2024

Accepted:

17.10.2024

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