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Yusupov F.A.

Osh State University

Yuldashev A.A.

Osh State University

Abdykadyrov M.Sh.

Osh State University

Yusupova T.F.

Osh State University

Effect of uric acid on the progression of Parkinson’s disease: Myth or reality?

Authors:

Yusupov F.A., Yuldashev A.A., Abdykadyrov M.Sh., Yusupova T.F.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(7): 7‑14

DOI: 10.17116/jnevro20251250717

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Table of contents

EFFECT OF URIC ACID ON THE PROGRESSION OF PARKINSON’S DISEASE: MYTH OR REALITY?
EFFECT OF URIC ACID ON THE PROGRESSION OF PARKINSON’S DISEASE: MYTH OR REALITY?

To cite this article:

Yusupov FA, Yuldashev AA, Abdykadyrov MSh, Yusupova TF. Effect of uric acid on the progression of Parkinson’s disease: Myth or reality? S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(7):7‑14. (In Russ.)
https://doi.org/10.17116/jnevro20251250717

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

Numerous studies showed an association between Parkinson’s disease and low uric acid levels. Low uric acid levels are associated with an increased risk of Parkinson’s disease, its progression, and the severity of symptoms. Although the biological mechanisms for this association have not yet been established, it is suggested that uric acid acts as an antioxidant, reducing oxidative stress and protecting dopaminergic neurons. However, some recent studies question this hypothesis. The article discusses the biological properties of uric acid, its relationship to Parkinson’s disease, and the possibility of reverse causation, where the disease causes a decrease in uric acid levels. The presented data support further research to understand these relationships more deeply, possibly leading to new disease treatment approaches.

Keywords:

uric acid
Parkinson’s disease
ATP
antioxidant
oxidative stress
purines
hyperuricemia
hypouricemia

Authors:

Yusupov F.A.

Osh State University

Yuldashev A.A.

Osh State University

Abdykadyrov M.Sh.

Osh State University

Yusupova T.F.

Osh State University

Received:

30.10.2024

Accepted:

22.11.2024

Close metadata

References:

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