The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Khovasova N.O.

Russian Gerontology Research and Clinical Centre — N.I. Pirogov Russian National Research Medical University

Naumov A.V.

Russian Gerontology Research and Clinical Centre — N.I. Pirogov Russian National Research Medical University

Unkovskiy A.V.

Russian Gerontology Research and Clinical Centre — N.I. Pirogov Russian National Research Medical University

Tkacheva O.N.

Russian Gerontology Research and Clinical Centre — N.I. Pirogov Russian National Research Medical University

Vitamin B12 deficiency in the elderly and its associations with geriatric syndromes

Authors:

Khovasova N.O., Naumov A.V., Unkovskiy A.V., Tkacheva O.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(10): 41‑47

DOI: 10.17116/jnevro202412410141

Read: 1746 times

Buy for 300₽
Contact the author
Table of contents

VITAMIN B12 DEFICIENCY IN THE ELDERLY AND ITS ASSOCIATIONS WITH GERIATRIC SYNDROMES
VITAMIN B12 DEFICIENCY IN THE ELDERLY AND ITS ASSOCIATIONS WITH GERIATRIC SYNDROMES

To cite this article:

Khovasova NO, Naumov AV, Unkovskiy AV, Tkacheva ON. Vitamin B12 deficiency in the elderly and its associations with geriatric syndromes. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(10):41‑47. (In Russ.)
https://doi.org/10.17116/jnevro202412410141

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Cognitive functions asse­ssment of elde­rly patients with type 2 diabetes mellitus. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):46-50
Rela­tionship between stroke-associated pneumonia and long-term outcomes of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):57-61
Analysis of cognitive status in patients with different noso­logies and clinical variants of very late mani­festing schi­zophreniform psychosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):88-93
Cardiogenic deme­ntia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):43-49
Reso­lution of the expert council «Possibilities of neuroprotective therapy in patients with arte­rial hype­rtension and cognitive diso­rders». Russian Journal of Preventive Medi­cine. 2024;(11):85-93
Frailty in patients with atrial fibrillation: diagnosis, mana­gement, prevention and influence on prognosis. Russian Cardiology Bulletin. 2025;(1):5-12
Differential diagnosis of anemia in ulce­rative coli­tis: a clinical case. Russian Journal of Evidence-Based Gastroenterology. 2025;(2):115-120
Possibilities of oral form of cyanocobalamin in pharmacological correction of vita­min B12 defi­ciency deve­loped in patients with type 2 diabetes mellitus during treatment with metformin. Russian Journal of Preventive Medi­cine. 2025;(9):64-69
Resu­lts of comprehensive geriatric evaluation in outpatients over 65 years old depe­nding on the presence of anemia. Suba­nalysis of the EVKA­LIPT study. Russian Journal of Preventive Medi­cine. 2025;(9):101-111
Abstract:

OBJECTIVE

To assess the frequency of geriatric syndromes (GS) and their relationship with vitamin B12 deficiency in elderly patients.

MATERIAL AND METHODS

The study included 222 people aged 60 years and older, 78.8% were women admitted to the geriatric ward as planned. All patients underwent general clinical studies, comprehensive geriatric assessment (CGO) and assessment of vitamin B12 concentration in the blood.

RESULTS

21.2% of patients were diagnosed with vitamin B12 deficiency. Vitamin B12 deficient patients performed worse on a number of tests included in the CGO: the chair test (p<0.001), walking speed (p<0.001), TUG (p=0.038), tandem tests (p=0.039), clock drawing test (p=0.043). The results of the MMSE, anxiety questionnaire, FRAX were also worse in patients with vitamin B12 deficiency. At the same time, the presence of vitamin B12 deficiency is associated with an increase in the risk of such GS as frailty, cognitive disorders, falls, fear of falls, high risk of fractures, polypharmacy, neuropathic pain, anxiety. Vitamin B12 — deficient patients were significantly more likely to take metformin, and the proton pump inhibitor group tended to take metformin more frequently.

CONCLUSION

Vitamin B12 deficiency is associated with a large number of GS.

Keywords:

geriatric syndrome
vitamin B12 deficiency
comprehensive geriatric assessment
frailty
cognitive disorders
falls

Authors:

Khovasova N.O.

Russian Gerontology Research and Clinical Centre — N.I. Pirogov Russian National Research Medical University

Naumov A.V.

Russian Gerontology Research and Clinical Centre — N.I. Pirogov Russian National Research Medical University

Unkovskiy A.V.

Russian Gerontology Research and Clinical Centre — N.I. Pirogov Russian National Research Medical University

Tkacheva O.N.

Russian Gerontology Research and Clinical Centre — N.I. Pirogov Russian National Research Medical University

Received:

11.09.2024

Accepted:

18.09.2024

Close metadata

References:

  1. Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Clinical guidelines on frailty. Russian Journal of Geriatric Medicine. 2020;(1):11-46. (In Russ.). https://doi.org/10.37586/2686-8636-1-2020-11-46
  2. Kuzuya M. Era of geriatric medical challenges: Multimorbidity among older patients. Geriatr Gerontol Int. 2019;19(8):699-704.  https://doi.org/10.1111/ggi.13742
  3. Cookian SM, Warner DF, Owusu C, et al. Multimorbidity redefined: prospective health outcomes and the cumulative effect of co-occurring conditions. Prev Chronic Dis. 2015;12:E55.  https://doi.org/10.5888/pcd12.140478
  4. Brito A, Grapov D, Fahrmann J, et al. The Human Serum Metabolome of Vitamin B-12 Deficiency and Repletion, and Associations with Neurological Function in Elderly Adults. J Nutr. 2017;147(10):1839-1849. https://doi.org/10.3945/jn.117.248278
  5. Vincenti A, Bertuzzo L, Limitone A, et al. Perspective: Practical Approach to Preventing Subclinical B12 Deficiency in Elderly Population. Nutrients. 2021;13(6):1913. https://doi.org/10.3390/nu13061913
  6. Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Annu Rev Nutr. 1999;19:357-377.  https://doi.org/10.1146/annurev.nutr.19.1.357
  7. Wong CW, Ip CY, Leung CP, et al. Vitamin B12 deficiency in the institutionalized elderly: A regional study. Exp Gerontol. 2015;69:221-225.  https://doi.org/10.1016/j.exger.2015.06.016
  8. Brito A, Mujica-Coopman MF, López de Romaña D, et al. Folate and Vitamin B12 Status in Latin America and the Caribbean: An Update. Food Nutr Bull. 2015;36(2 Suppl):S109-118.  https://doi.org/10.1177/0379572115585772
  9. Andrès E, Loukili NH, Noel E, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004;171(3):251-259.  https://doi.org/10.1503/cmaj.1031155
  10. Gyawali P, Bhatt RD, Karmacharya RM, et al. High Burden of Vitamin B12 Deficiency among Adults and Elderly. J Nepal Health Res Counc. 2023;20(3):702-707.  https://doi.org/10.33314/jnhrc.v20i3.4407
  11. Pfeiffer CM, Hughes JP, Lacher DA, et al. Estimation of trends in serum and RBC folate in the U.S. population from pre- to postfortification using assay-adjusted data from the NHANES 1988-2010. J Nutr. 2012;142(5):886-893.  https://doi.org/10.3945/jn.111.156919
  12. Deficiency of vitamin B12. Clinical guidelines. 2023. (In Russ.).
  13. Soh Y, Won CW. Association between frailty and vitamin B12 in the older Korean population. Medicine (Baltimore). 2020;99(43):e22327. https://doi.org/10.1097/MD.0000000000022327
  14. Balboa-Castillo T, Struijk EA, Lopez-Garcia E, et al. Low vitamin intake is associated with risk of frailty in older adults. Age Ageing. 2018;47(6):872-879.  https://doi.org/10.1093/ageing/afy105
  15. Dhonukshe-Rutten RA, Pluijm SM, de Groot LC, et al. Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res. 2005;20(6):921-929.  https://doi.org/10.1359/JBMR.050202
  16. Stone KL, Bauer DC, Sellmeyer D, et al. Low serum vitamin B12 levels are associated with increased hip bone loss in older women: a prospective study. J Clin Endocrinol Metab. 2004;89(3):1217-1221. https://doi.org/10.1210/jc.2003-030074
  17. Macêdo LLG, Carvalho CMRG, Cavalcanti JC, et al. Vitamin B12, bone mineral density and fracture risk in adults: A systematic review. Rev Assoc Med Bras (1992). 2017;63(9):801-809.  https://doi.org/10.1590/1806-9282.63.09.801
  18. Aguilar-Navarro SG, Carbajal-Silva JC, Palacios-Hernández MGI, et al. Association between vitamin B12 levels and cognitive impairment in older adults. Gac Med Mex. 2023;159(1):32-37.  https://doi.org/10.24875/GMM.M22000733
  19. Mizrahi EH, Lubart E, Leibovitz A. Low Borderline Levels of Serum Vitamin B12 May Predict Cognitive Decline in Elderly Hip Fracture Patients. Isr Med Assoc J. 2017;19(5):305-308. 
  20. Sashindran VK, Aggarwal V, Khera A. Prevalence of Vitamin B12 deficiency in elderly population (>60 years) presenting with dementia to outpatient department. Med J Armed Forces India. 2022;78(1):94-98.  https://doi.org/10.1016/j.mjafi.2020.11.003
  21. Zik C. Late Life Vitamin B12 Deficiency. Clin Geriatr Med. 2019;35(3):319-325.  https://doi.org/10.1016/j.mjafi.2020.11.003
  22. Kerlikowsky F, Schuchardt JP, Hahn A. Folate, vitamin B12 and vitamin D status in healthy and active home-dwelling people over 70 years. BMC Geriatr. 2023;23(1):673.  https://doi.org/10.1186/s12877-023-04391-2
  23. Porter KM, Hoey L, Hughes CF, et al. Associations of atrophic gastritis and proton-pump inhibitor drug use with vitamin B-12 status, and the impact of fortified foods, in older adults. Am J Clin Nutr. 2021;114(4):1286-1294. https://doi.org/10.1093/ajcn/nqab193
  24. Marchi G, Busti F, Zidanes AL, et al. Cobalamin Deficiency in the Elderly. Mediterr J Hematol Infect Dis. 2020;12(1):e2020043. https://doi.org/10.4084/MJHID.2020.043
  25. Hurley-Kim K, Vu CH, Dao NM, et al. Effect of Metformin Use on Vitamin B12 Deficiency Over Time (EMBER): A Real-World Evidence Database Study. Endocr Pract. 2023;29(11):862-867.  https://doi.org/10.1016/j.eprac.2023.06.013
  26. Deficiency/Deficit of vitamin B12 in clinical practice. Resolution of the advisory board. Russian Journal of Preventive Medicine. 2023;26(1):109-113. (In Russ.). https://doi.org/10.17116/profmed202326011109
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.