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Ierusalimsky N.V.

Institute of Higher Nervous Activity and Neurophysiology;
Scientific and Practical Psychoneurological Center

Karimova E.D.

Institute of Higher Nervous Activity and Neurophysiology;
Scientific and Practical Psychoneurological Center

Samotaeva I.S.

Institute of Higher Nervous Activity and Neurophysiology;
Scientific and Practical Psychoneurological Center

Luzin R.V.

Scientific and Practical Psychoneurological Center

Zinchuk M.S.

Scientific and Practical Psychoneurological Center

Rider F.K.

Moscow Research and Clinical Centre for Neuropsychiatry

Guekht A.B.

Moscow Research and Clinical Centre for Neuropsychiatry;
Pirogov Russian National Research Medical University

Structural brain changes in patients with temporal lobe epilepsy and comorbid depression

Authors:

Ierusalimsky N.V., Karimova E.D., Samotaeva I.S., Luzin R.V., Zinchuk M.S., Rider F.K., Guekht A.B.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(9): 83‑89

DOI: 10.17116/jnevro202312309183

Read: 2407 times

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Table of contents

STRUCTURAL BRAIN CHANGES IN PATIENTS WITH TEMPORAL LOBE EPILEPSY AND COMORBID DEPRESSION
STRUCTURAL BRAIN CHANGES IN PATIENTS WITH TEMPORAL LOBE EPILEPSY AND COMORBID DEPRESSION

To cite this article:

Ierusalimsky NV, Karimova ED, Samotaeva IS, Luzin RV, Zinchuk MS, Rider FK, Guekht AB. Structural brain changes in patients with temporal lobe epilepsy and comorbid depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(9):83‑89. (In Russ.)
https://doi.org/10.17116/jnevro202312309183

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To assess the morphological features of the brain structures in patients with temporal lobe epilepsy and comorbid depression.

MATERIAL AND METHODS

From 1 January 2017 to 31 December 2020, we studied 80 patients with temporal lobe epilepsy (aged 18—60 years, 38 of whom had comorbid depression) and 48 healthy subjects of comparable age. Magnetic resonance imaging (MRI) of the brain was performed using the epilepsy protocol in a scanner with a magnetic field strength of 1.5 T. Focal temporal lobe epilepsy was diagnosed by neurologists (epileptologists) specialising in epilepsy according to the International League Against Epilepsy (ILAE) classification of epilepsy. Psychiatrists assessed the presence and severity of depressive disorders by clinical interview and by participants’ scores on the Beck Depression Inventory (BDI-II). MRI data were processed using FreeSurfer 6.0 software to determine volumes of subcortical structures and thicknesses of cortical structures. At the group level, analysis of covariance with Holm-Bonferroni correction was used as the statistical method.

RESULTS

Morphometric analysis revealed a significant decrease in the volume of the thalamus bilaterally and the brain stem and an increase in the volume of the choroid plexus in the left hemisphere, as well as a significant decrease in the thickness of the entorhinal cortex, temporal pole and isthmus of the cingulate gyrus in the left hemisphere and middle temporal gyrus and inferior temporal gyrus in the right hemisphere in patients with epilepsy compared to healthy controls. No association was found between the presence of depression and significant structural changes on MRI.

CONCLUSION

The data obtained suggest an effect of temporal lobe epilepsy, but not comorbid depression, on the morphology of brain structures.

Keywords:

magnetic resonance imaging
temporal lobe epilepsy
depression
morphometric analysis

Authors:

Ierusalimsky N.V.

Institute of Higher Nervous Activity and Neurophysiology;
Scientific and Practical Psychoneurological Center

Karimova E.D.

Institute of Higher Nervous Activity and Neurophysiology;
Scientific and Practical Psychoneurological Center

Samotaeva I.S.

Institute of Higher Nervous Activity and Neurophysiology;
Scientific and Practical Psychoneurological Center

Luzin R.V.

Scientific and Practical Psychoneurological Center

Zinchuk M.S.

Scientific and Practical Psychoneurological Center

Rider F.K.

Moscow Research and Clinical Centre for Neuropsychiatry

Guekht A.B.

Moscow Research and Clinical Centre for Neuropsychiatry;
Pirogov Russian National Research Medical University

Received:

22.05.2023

Accepted:

22.05.2023

Close metadata

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